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Journal of Autism and Developmental Disorders

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01-05-2007 | Original Paper

[³H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study

Auteurs: Jeffrey T. Guptill, Anne B. Booker, Terrell T. Gibbs, Thomas L. Kemper, Margaret L. Bauman, Gene J. Blatt

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2007

Abstract

Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [³H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B _max) or altered affinity (K _d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B _max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K _d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABA_A receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry.

vorige artikel Describing the Sensory Abnormalities of Children and Adults with Autism

volgende artikel Improving the Reliability of Autism Diagnoses: Examining the Utility of Adaptive Behavior

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Titel: [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study
Auteurs: Jeffrey T. Guptill
Anne B. Booker
Terrell T. Gibbs
Thomas L. Kemper
Margaret L. Bauman
Gene J. Blatt
Publicatiedatum: 01-05-2007
Uitgeverij: Kluwer Academic Publishers-Plenum Publishers
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0226-7

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