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Gepubliceerd in: Research on Child and Adolescent Psychopathology 4/2019

15-08-2018

Extinction Learning as a Potential Mechanism Linking High Vagal Tone with Lower PTSD Symptoms among Abused Youth

Auteurs: Jessica L. Jenness, Adam Bryant Miller, Maya L. Rosen, Katie A. McLaughlin

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 4/2019

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Abstract

Childhood abuse is a potent risk factor for psychopathology, including posttraumatic stress disorder (PTSD). Research has shown high resting vagal tone, a measure of parasympathetic nervous system function, protects abused youth from developing internalizing psychopathology, but potential mechanisms explaining this effect are unknown. We explored fear extinction learning as a possible mechanism underlying the protective effect of vagal tone on PTSD symptoms among abused youth. We measured resting respiratory sinus arrhythmia (RSA) and skin conductance responses (SCR) during a fear conditioning and extinction task in youth with variability in abuse exposure (N = 94; aged 6–18 years). High RSA predicted lower PTSD symptoms and enhanced extinction learning among abused youths. In a moderated-mediation model, extinction learning mediated the association of abuse with PTSD symptoms only among youth with high RSA. These findings highlight extinction learning as a possible mechanism linking high vagal tone to decreased risk for PTSD symptoms among abused youth.
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Literatuur
go back to reference Allen, J. J., Chambers, A. S., & Towers, D. N. (2007). The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74(2), 243–262.CrossRef Allen, J. J., Chambers, A. S., & Towers, D. N. (2007). The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74(2), 243–262.CrossRef
go back to reference Bauer, D. J., & Curran, P. J. (2005). Probing interactions in fixed and multilevel regression: Inferential and graphical techniques. Multivariate behavioral research, 40(3), 373–400. Bauer, D. J., & Curran, P. J. (2005). Probing interactions in fixed and multilevel regression: Inferential and graphical techniques. Multivariate behavioral research, 40(3), 373–400.
go back to reference Beauchaine, T. (2001). Vagal tone, development, and Gray’s motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13(02), 183–214.CrossRef Beauchaine, T. (2001). Vagal tone, development, and Gray’s motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13(02), 183–214.CrossRef
go back to reference Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885–908.CrossRef Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885–908.CrossRef
go back to reference Bernstein, D. P., Ahluvalia, T., Pogge, D., & Handelsman, L. (1997). Validity of the childhood trauma questionnaire in an adolescent psychiatric population. Journal of the American Academy of Child & Adolescent Psychiatry, 36(3), 340–348.CrossRef Bernstein, D. P., Ahluvalia, T., Pogge, D., & Handelsman, L. (1997). Validity of the childhood trauma questionnaire in an adolescent psychiatric population. Journal of the American Academy of Child & Adolescent Psychiatry, 36(3), 340–348.CrossRef
go back to reference Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology, 30(2), 183–196.CrossRef Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications. Psychophysiology, 30(2), 183–196.CrossRef
go back to reference Berntson, G G, Bigger, J. T., Jr, Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., … van der Molen, M. W. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34(6), 623–648. Berntson, G G, Bigger, J. T., Jr, Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., … van der Molen, M. W. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34(6), 623–648.
go back to reference Bifulco, A., Brown, G. W., & Harris, T. O. (1994). Childhood experience of care and abuse (CECA): A retrospective interview measure. Journal of Child Psychology and Psychiatry, 35(8), 1419–1435.CrossRef Bifulco, A., Brown, G. W., & Harris, T. O. (1994). Childhood experience of care and abuse (CECA): A retrospective interview measure. Journal of Child Psychology and Psychiatry, 35(8), 1419–1435.CrossRef
go back to reference Cacioppo, J. T., Tassinary, L. G., & Berntson, G. (2007). Handbook of psychophysiology. Cambridge University Press. Cacioppo, J. T., Tassinary, L. G., & Berntson, G. (2007). Handbook of psychophysiology. Cambridge University Press.
go back to reference Calkins, S. D., & Keane, S. P. (2004). Cardiac vagal regulation across the preschool period: Stability, continuity, and implications for childhood adjustment. Developmental Psychobiology, 45(3), 101–112.CrossRef Calkins, S. D., & Keane, S. P. (2004). Cardiac vagal regulation across the preschool period: Stability, continuity, and implications for childhood adjustment. Developmental Psychobiology, 45(3), 101–112.CrossRef
go back to reference Calkins, S. D., Graziano, P. A., & Keane, S. P. (2007). Cardiac vagal regulation differentiates among children at risk for behavior problems. Biological Psychology, 74(2), 144–153.CrossRef Calkins, S. D., Graziano, P. A., & Keane, S. P. (2007). Cardiac vagal regulation differentiates among children at risk for behavior problems. Biological Psychology, 74(2), 144–153.CrossRef
go back to reference Childs, J. E., DeLeon, J., Nickel, E., & Kroener, S. (2017). Vagus nerve stimulation reduces cocaine seeking and alters plasticity in the extinction network. Learning & Memory, 24(1), 35–42.CrossRef Childs, J. E., DeLeon, J., Nickel, E., & Kroener, S. (2017). Vagus nerve stimulation reduces cocaine seeking and alters plasticity in the extinction network. Learning & Memory, 24(1), 35–42.CrossRef
go back to reference Daban, C., Martinez-Aran, A., Cruz, N., & Vieta, E. (2008). Safety and efficacy of Vagus nerve stimulation in treatment-resistant depression. A systematic review. Journal of Affective Disorders, 110(1), 1–15.CrossRef Daban, C., Martinez-Aran, A., Cruz, N., & Vieta, E. (2008). Safety and efficacy of Vagus nerve stimulation in treatment-resistant depression. A systematic review. Journal of Affective Disorders, 110(1), 1–15.CrossRef
go back to reference Dawson, M. E., Schell, A. M., & Filion, D. L. (2007). The electrodermal system. Handbook of Psychophysiology, 2, 200–223. Dawson, M. E., Schell, A. M., & Filion, D. L. (2007). The electrodermal system. Handbook of Psychophysiology, 2, 200–223.
go back to reference Descilo, T., Vedamurtachar, A., Gerbarg, P. L., Nagaraja, D., Gangadhar, B. N., Damodaran, B., Adelson, B., Braslow, L. H., Marcus, S., & Brown, R. P. (2010). Effects of a yoga breath intervention alone and in combination with an exposure therapy for post-traumatic stress disorder and depression in survivors of the 2004 South-East Asia tsunami. Acta Psychiatrica Scandinavica, 121(4), 289–300.CrossRef Descilo, T., Vedamurtachar, A., Gerbarg, P. L., Nagaraja, D., Gangadhar, B. N., Damodaran, B., Adelson, B., Braslow, L. H., Marcus, S., & Brown, R. P. (2010). Effects of a yoga breath intervention alone and in combination with an exposure therapy for post-traumatic stress disorder and depression in survivors of the 2004 South-East Asia tsunami. Acta Psychiatrica Scandinavica, 121(4), 289–300.CrossRef
go back to reference Dorsey, S., Briggs, E. C., & Woods, B. A. (2011). Cognitive-behavioral treatment for posttraumatic stress disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 20(2), 255–269.CrossRef Dorsey, S., Briggs, E. C., & Woods, B. A. (2011). Cognitive-behavioral treatment for posttraumatic stress disorder in children and adolescents. Child and Adolescent Psychiatric Clinics of North America, 20(2), 255–269.CrossRef
go back to reference El-Sheikh, M., & Whitson, S. A. (2006). Longitudinal relations between marital conflict and child adjustment: Vagal regulation as a protective factor. Journal of Family Psychology, 20(1), 30–39.CrossRef El-Sheikh, M., & Whitson, S. A. (2006). Longitudinal relations between marital conflict and child adjustment: Vagal regulation as a protective factor. Journal of Family Psychology, 20(1), 30–39.CrossRef
go back to reference El-Sheikh, M., Harger, J., & Whitson, S. M. (2001). Exposure to interparental conflict and children’s adjustment and physical health: The moderating role of vagal tone. Child Development, 72(6), 1617–1636.CrossRef El-Sheikh, M., Harger, J., & Whitson, S. M. (2001). Exposure to interparental conflict and children’s adjustment and physical health: The moderating role of vagal tone. Child Development, 72(6), 1617–1636.CrossRef
go back to reference Friedman, B. H. (2007). An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone. Biological Psychology, 74(2), 185–199.CrossRef Friedman, B. H. (2007). An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone. Biological Psychology, 74(2), 185–199.CrossRef
go back to reference Glover, E. M., Phifer, J. E., Crain, D. F., Norrholm, S. D., Davis, M., Bradley, B., Ressler, K. J., & Jovanovic, T. (2011). Tools for translational neuroscience: PTSD is associated with heightened fear responses using acoustic startle but not skin conductance measures. Depression and Anxiety, 28(12), 1058–1066. https://doi.org/10.1002/da.20880.CrossRefPubMed Glover, E. M., Phifer, J. E., Crain, D. F., Norrholm, S. D., Davis, M., Bradley, B., Ressler, K. J., & Jovanovic, T. (2011). Tools for translational neuroscience: PTSD is associated with heightened fear responses using acoustic startle but not skin conductance measures. Depression and Anxiety, 28(12), 1058–1066. https://​doi.​org/​10.​1002/​da.​20880.CrossRefPubMed
go back to reference Guthrie, R. M., & Bryant, R. A. (2005). Auditory startle response in firefighters before and after trauma exposure. American Journal of Psychiatry, 162(2), 283–290.CrossRef Guthrie, R. M., & Bryant, R. A. (2005). Auditory startle response in firefighters before and after trauma exposure. American Journal of Psychiatry, 162(2), 283–290.CrossRef
go back to reference Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York: Guilford Press. Hayes, A. F. (2013). Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York: Guilford Press.
go back to reference Katz, L. F., & Gottman, J. M. (1995). Vagal tone protects children from marital conflict. Development and Psychopathology, 7(1), 83–92.CrossRef Katz, L. F., & Gottman, J. M. (1995). Vagal tone protects children from marital conflict. Development and Psychopathology, 7(1), 83–92.CrossRef
go back to reference Lane, R. D., McRae, K., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2009). Neural correlates of heart rate variability during emotion. Neuroimage, 44(1), 213–222.CrossRef Lane, R. D., McRae, K., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2009). Neural correlates of heart rate variability during emotion. Neuroimage, 44(1), 213–222.CrossRef
go back to reference Liu, J., Fang, J., Wang, Z., Rong, P., Hong, Y., Fan, Y., … others. (2016). Transcutaneous vagus nerve stimulation modulates amygdala functional connectivity in patients with depression. Journal of Affective Disorders, 205, 319–326. Liu, J., Fang, J., Wang, Z., Rong, P., Hong, Y., Fan, Y., … others. (2016). Transcutaneous vagus nerve stimulation modulates amygdala functional connectivity in patients with depression. Journal of Affective Disorders, 205, 319–326.
go back to reference Lucini, D., Di Fede, G., Parati, G., & Pagani, M. (2005). Impact of chronic psychosocial stress on autonomic cardiovascular regulation in otherwise healthy subjects. Hypertension, 46(5), 1201–1206.CrossRef Lucini, D., Di Fede, G., Parati, G., & Pagani, M. (2005). Impact of chronic psychosocial stress on autonomic cardiovascular regulation in otherwise healthy subjects. Hypertension, 46(5), 1201–1206.CrossRef
go back to reference McLaughlin, K. A., & Sheridan, M. A. (2016). Beyond cumulative risk: A dimensional approach to childhood adversity. Current Directions in Psychological Science, 25(4), 239–245.CrossRef McLaughlin, K. A., & Sheridan, M. A. (2016). Beyond cumulative risk: A dimensional approach to childhood adversity. Current Directions in Psychological Science, 25(4), 239–245.CrossRef
go back to reference McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2012). Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Archives of General Psychiatry, 69(11), 1151–1160.CrossRef McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2012). Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Archives of General Psychiatry, 69(11), 1151–1160.CrossRef
go back to reference McLaughlin, K. A., Koenen, K. C., Hill, E. D., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2013). Trauma exposure and posttraumatic stress disorder in a national sample of adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 52(8), 815–830.CrossRef McLaughlin, K. A., Koenen, K. C., Hill, E. D., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2013). Trauma exposure and posttraumatic stress disorder in a national sample of adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 52(8), 815–830.CrossRef
go back to reference McLaughlin, K. A., Alves, S., & Sheridan, M. A. (2014a). Vagal regulation and internalizing psychopathology among adolescents exposed to childhood adversity. Developmental Psychobiology, 56(5), 1036–1051.CrossRef McLaughlin, K. A., Alves, S., & Sheridan, M. A. (2014a). Vagal regulation and internalizing psychopathology among adolescents exposed to childhood adversity. Developmental Psychobiology, 56(5), 1036–1051.CrossRef
go back to reference McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014b). Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience. Neuroscience & Biobehavioral Reviews, 47, 578–591.CrossRef McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014b). Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience. Neuroscience & Biobehavioral Reviews, 47, 578–591.CrossRef
go back to reference McLaughlin, K. A., Rith-Najarian, L., Dirks, M. A., & Sheridan, M. A. (2015). Low vagal tone magnifies the association between psychosocial stress exposure and internalizing psychopathology in adolescents. Journal of Clinical Child & Adolescent Psychology, 44(2), 314–328.CrossRef McLaughlin, K. A., Rith-Najarian, L., Dirks, M. A., & Sheridan, M. A. (2015). Low vagal tone magnifies the association between psychosocial stress exposure and internalizing psychopathology in adolescents. Journal of Clinical Child & Adolescent Psychology, 44(2), 314–328.CrossRef
go back to reference Mezzacappa, E., Kindlon, D., Saul, J. P., & Earls, F. (1998). Executive and motivational control of performance task behavior, and autonomic heart-rate regulation in children: Physiologic validation of two-factor solution inhibitory control. Journal of Child Psychology and Psychiatry, 39(4), 525–531.CrossRef Mezzacappa, E., Kindlon, D., Saul, J. P., & Earls, F. (1998). Executive and motivational control of performance task behavior, and autonomic heart-rate regulation in children: Physiologic validation of two-factor solution inhibitory control. Journal of Child Psychology and Psychiatry, 39(4), 525–531.CrossRef
go back to reference Milad, M. R., & Quirk, G. J. (2002). Neurons in medial prefrontal cortex signal memory for fear extinction. Nature, 420(6911), 70–74.CrossRef Milad, M. R., & Quirk, G. J. (2002). Neurons in medial prefrontal cortex signal memory for fear extinction. Nature, 420(6911), 70–74.CrossRef
go back to reference Milad, M. R., & Quirk, G. J. (2012). Fear extinction as a model for translational neuroscience: Ten years of progress. Annual Review of Psychology, 63, 129–151.CrossRef Milad, M. R., & Quirk, G. J. (2012). Fear extinction as a model for translational neuroscience: Ten years of progress. Annual Review of Psychology, 63, 129–151.CrossRef
go back to reference Neumann, S. A., Brown, S. M., Ferrell, R. E., Flory, J. D., Manuck, S. B., & Hariri, A. R. (2006). Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function. Biological Psychiatry, 60(10), 1155–1162.CrossRef Neumann, S. A., Brown, S. M., Ferrell, R. E., Flory, J. D., Manuck, S. B., & Hariri, A. R. (2006). Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function. Biological Psychiatry, 60(10), 1155–1162.CrossRef
go back to reference Peña, D. F., Engineer, N. D., & McIntyre, C. K. (2013). Rapid remission of conditioned fear expression with extinction training paired with vagus nerve stimulation. Biological Psychiatry, 73(11), 1071–1077.CrossRef Peña, D. F., Engineer, N. D., & McIntyre, C. K. (2013). Rapid remission of conditioned fear expression with extinction training paired with vagus nerve stimulation. Biological Psychiatry, 73(11), 1071–1077.CrossRef
go back to reference Pine, D. S., Wasserman, G. A., Miller, L., Coplan, J. D., Bagiella, E., Kovelenku, P., et al. (1998). Heart period variability and psychopathology in urban boys at risk for delinquency. Psychophysiology, 35(5), 521–529.CrossRef Pine, D. S., Wasserman, G. A., Miller, L., Coplan, J. D., Bagiella, E., Kovelenku, P., et al. (1998). Heart period variability and psychopathology in urban boys at risk for delinquency. Psychophysiology, 35(5), 521–529.CrossRef
go back to reference Pole, N., Neylan, T. C., Otte, C., Henn-Hasse, C., Metzler, T. J., & Marmar, C. R. (2009). Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biological Psychiatry, 65(3), 235–240.CrossRef Pole, N., Neylan, T. C., Otte, C., Henn-Hasse, C., Metzler, T. J., & Marmar, C. R. (2009). Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses. Biological Psychiatry, 65(3), 235–240.CrossRef
go back to reference Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology, 32(4), 301–318.CrossRef Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology, 32(4), 301–318.CrossRef
go back to reference Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74(2), 116–143.CrossRef Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74(2), 116–143.CrossRef
go back to reference Raine, A. (1996). Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior biosocial perspectives and treatment implications. Annals of the New York Academy of Sciences, 794(1), 46–59.CrossRef Raine, A. (1996). Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior biosocial perspectives and treatment implications. Annals of the New York Academy of Sciences, 794(1), 46–59.CrossRef
go back to reference Shannon, K. E., Beauchaine, T. P., Brenner, S. L., Neuhaus, E., & Gatzke-Kopp, L. (2007). Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression. Development and Psychopathology, 19(03), 701–727.CrossRef Shannon, K. E., Beauchaine, T. P., Brenner, S. L., Neuhaus, E., & Gatzke-Kopp, L. (2007). Familial and temperamental predictors of resilience in children at risk for conduct disorder and depression. Development and Psychopathology, 19(03), 701–727.CrossRef
go back to reference Shechner, T., Britton, J. C., Ronkin, E. G., Jarcho, J. M., Mash, J. A., Michalska, K. J., Leibenluft, E., & Pine, D. S. (2015). Fear conditioning and extinction in anxious and nonanxious youth and adults: Examining a novel developmentally appropriate fear-conditioning task. Depression and Anxiety, 32(4), 277–288. https://doi.org/10.1002/da.22318.CrossRefPubMed Shechner, T., Britton, J. C., Ronkin, E. G., Jarcho, J. M., Mash, J. A., Michalska, K. J., Leibenluft, E., & Pine, D. S. (2015). Fear conditioning and extinction in anxious and nonanxious youth and adults: Examining a novel developmentally appropriate fear-conditioning task. Depression and Anxiety, 32(4), 277–288. https://​doi.​org/​10.​1002/​da.​22318.CrossRefPubMed
go back to reference Steinberg, A. M., Brymer, M. J., Decker, K. B., & Pynoos, R. S. (2004). The University of California at Los Angeles post-traumatic stress disorder reaction index. Current Psychiatry Reports, 6(2), 96–100.CrossRef Steinberg, A. M., Brymer, M. J., Decker, K. B., & Pynoos, R. S. (2004). The University of California at Los Angeles post-traumatic stress disorder reaction index. Current Psychiatry Reports, 6(2), 96–100.CrossRef
go back to reference Thayer, J. F., Ahs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience & Biobehavioral Reviews, 36(2), 747–756.CrossRef Thayer, J. F., Ahs, F., Fredrikson, M., Sollers, J. J., & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience & Biobehavioral Reviews, 36(2), 747–756.CrossRef
go back to reference Vouimba, R.-M., & Maroun, M. (2011). Learning-induced changes in mPFC–BLA connections after fear conditioning, extinction, and reinstatement of fear. Neuropsychopharmacology, 36(11), 2276–2285.CrossRef Vouimba, R.-M., & Maroun, M. (2011). Learning-induced changes in mPFC–BLA connections after fear conditioning, extinction, and reinstatement of fear. Neuropsychopharmacology, 36(11), 2276–2285.CrossRef
go back to reference Walker, E. A., Unutzer, J., Rutter, C., Gelfand, A., Saunders, K., VonKorff, M., & Katon, W. (1999). Costs of health care use by women HMO members with a history of childhood abuse and neglect. Archives of General Psychiatry, 56(7), 609–613. Walker, E. A., Unutzer, J., Rutter, C., Gelfand, A., Saunders, K., VonKorff, M., & Katon, W. (1999). Costs of health care use by women HMO members with a history of childhood abuse and neglect. Archives of General Psychiatry, 56(7), 609–613.
go back to reference Widom, C. S., Weiler, B. L., & Cottler, L. B. (1999). Childhood victimization and drug abuse: A comparison of prospective and retrospective findings. Journal of consulting and clinical psychology, 67(6), 867. Widom, C. S., Weiler, B. L., & Cottler, L. B. (1999). Childhood victimization and drug abuse: A comparison of prospective and retrospective findings. Journal of consulting and clinical psychology, 67(6), 867.
Metagegevens
Titel
Extinction Learning as a Potential Mechanism Linking High Vagal Tone with Lower PTSD Symptoms among Abused Youth
Auteurs
Jessica L. Jenness
Adam Bryant Miller
Maya L. Rosen
Katie A. McLaughlin
Publicatiedatum
15-08-2018
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 4/2019
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-018-0464-0

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