Skip to main content
Top
Gepubliceerd in: Journal of Abnormal Child Psychology 1/2018

18-02-2017

HPA-Axis Activation as a Key Moderator of Childhood Trauma Exposure and Adolescent Mental Health

Auteurs: Kate R. Kuhlman, Elisa G. Geiss, Ivan Vargas, Nestor Lopez-Duran

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 1/2018

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Individual differences in a child’s sensitivity to stress may influence whether youth exposed to trauma develop symptoms of psychopathology. We examined the interaction between HPA-axis reactivity to an acute stressor and exposure to different types of childhood trauma as predictors of mental health symptoms in a sample of youth. Youth (n = 121, ages 9–16; 47% female) completed a standardized stress task, including 5 post-stress salivary cortisol samples. Parents also completed the Child Behavior Checklist as a measure of child internalizing and externalizing symptoms in the past month, and completed the Early Trauma Inventory (ETI) as a measure of their child’s trauma exposure. More emotional abuse and non-intentional trauma were associated with greater internalizing symptoms. Youth exposed to physical abuse who demonstrated slower HPA-axis reactivity had elevated internalizing and externalizing symptoms. Youth exposed to emotional abuse or non-intentional traumatic events who demonstrated faster HPA-axis reactivity had elevated internalizing and externalizing symptoms. Profiles of exaggerated or attenuated HPA-axis reactivity to acute stress may be risk factors for psychopathology in children facing different stressful social environments.
Voetnoten
1
Previous investigations using this sample found exposure to any trauma during infancy was related to patterns of within-subject change in HPA-axis reactivity, however the pattern of results in the adjusted models remain unchanged when accounting for exposure to any trauma during infancy (Kuhlman et al. 2015b).
 
Literatuur
go back to reference Achenbach, T. M. (1991). Child behavior checklist/4–18. Burlington: University of Vermont, Department of Psychiatry. Achenbach, T. M. (1991). Child behavior checklist/4–18. Burlington: University of Vermont, Department of Psychiatry.
go back to reference Bremner, J. D., Vermetten, E., & Mazure, C. M. (2000). Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: the early trauma inventory. Depression and Anxiety, 12, 1–12. doi:10.1002/1520-6394(2000)12.CrossRefPubMed Bremner, J. D., Vermetten, E., & Mazure, C. M. (2000). Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: the early trauma inventory. Depression and Anxiety, 12, 1–12. doi:10.​1002/​1520-6394(2000)12.CrossRefPubMed
go back to reference Chapman, D. P., Dube, S. R., & Anda, R. F. (2007). Adverse childhood events as risk factors for negative mental health outcomes. Psychiatric Annals, 37, 359–364. Chapman, D. P., Dube, S. R., & Anda, R. F. (2007). Adverse childhood events as risk factors for negative mental health outcomes. Psychiatric Annals, 37, 359–364.
go back to reference Goenjian, A. K., Yehuda, R., Pynoos, R. S., Steinberg, A. M., Tashjian, M., Yang, R. K., et al. (1996). Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia. The American Journal of Psychiatry, 153, 929–934. doi:10.1176/ajp.153.7.929.CrossRefPubMed Goenjian, A. K., Yehuda, R., Pynoos, R. S., Steinberg, A. M., Tashjian, M., Yang, R. K., et al. (1996). Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia. The American Journal of Psychiatry, 153, 929–934. doi:10.​1176/​ajp.​153.​7.​929.CrossRefPubMed
go back to reference Gunnar, M. R., & Quevedo, K. M. (2007). Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability. In R. De Kloet, M. S. Oitzl, & E. Vermetten (Eds.), Progress in brain research (Vol. 167, pp. 137–149). Amsterdam, The Netherlands: Elsevier B.V. Gunnar, M. R., & Quevedo, K. M. (2007). Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability. In R. De Kloet, M. S. Oitzl, & E. Vermetten (Eds.), Progress in brain research (Vol. 167, pp. 137–149). Amsterdam, The Netherlands: Elsevier B.V.
go back to reference Hagan, M. J., Roubinov, D. S., Gress-Smith, J., Luecken, L. J., Sandler, I. N., & Wolchik, S. (2010). Positive parenting during childhood moderates the impact of recent negative events on cortisol activity in parentally bereaved youth. Psychopharmacology, 214, 231–238. doi:10.1007/s00213-010-1889-5.CrossRefPubMedPubMedCentral Hagan, M. J., Roubinov, D. S., Gress-Smith, J., Luecken, L. J., Sandler, I. N., & Wolchik, S. (2010). Positive parenting during childhood moderates the impact of recent negative events on cortisol activity in parentally bereaved youth. Psychopharmacology, 214, 231–238. doi:10.​1007/​s00213-010-1889-5.CrossRefPubMedPubMedCentral
go back to reference Hagan, M. J., Roubinov, D. S., Mistler, A. K., & Luecken, L. J. (2014). Mental health outcomes in emerging adults exposed to childhood maltreatment the moderating role of stress reactivity. Child Maltreatment, 19, 156–167. doi:10.1177/1077559514539753.CrossRefPubMed Hagan, M. J., Roubinov, D. S., Mistler, A. K., & Luecken, L. J. (2014). Mental health outcomes in emerging adults exposed to childhood maltreatment the moderating role of stress reactivity. Child Maltreatment, 19, 156–167. doi:10.​1177/​1077559514539753​.CrossRefPubMed
go back to reference Hammerfald, K., Eberle, C., Grau, M., Kinsperger, A., Zimmermann, A., Ehlert, U., & Gaab, J. (2006). Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects—a randomized controlled trial. Psychoneuroendocrinology, 31, 333–339. doi:10.1016/j.psyneuen.2005.08.007.CrossRefPubMed Hammerfald, K., Eberle, C., Grau, M., Kinsperger, A., Zimmermann, A., Ehlert, U., & Gaab, J. (2006). Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects—a randomized controlled trial. Psychoneuroendocrinology, 31, 333–339. doi:10.​1016/​j.​psyneuen.​2005.​08.​007.CrossRefPubMed
go back to reference Hofstra, M. B., Van der Ende, J., & Verhulst, F. C. (2000). Continuity and change of psychopathology from childhood into adulthood: a 14-year follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 850. doi:10.1097/00004583-200007000-00013.CrossRefPubMed Hofstra, M. B., Van der Ende, J., & Verhulst, F. C. (2000). Continuity and change of psychopathology from childhood into adulthood: a 14-year follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 850. doi:10.​1097/​00004583-200007000-00013.CrossRefPubMed
go back to reference Johnston, C. A., Steele, R. G., Herrera, E. A., & Phipps, S. (2003). Parent and child reporting of negative life events: discrepancy and agreement across pediatric samples. Journal of Pediatric Psychology, 28, 579.CrossRefPubMed Johnston, C. A., Steele, R. G., Herrera, E. A., & Phipps, S. (2003). Parent and child reporting of negative life events: discrepancy and agreement across pediatric samples. Journal of Pediatric Psychology, 28, 579.CrossRefPubMed
go back to reference Kuhlman, K. R., Olson, S. L., & Lopez-Duran, N. L. (2014). Predicting developmental changes in internalizing symptoms: examining the interplay between parenting and neuroendocrine stress reactivity. Developmental Psychobiology, 56, 908–923. doi:10.1002/dev.21166.CrossRefPubMed Kuhlman, K. R., Olson, S. L., & Lopez-Duran, N. L. (2014). Predicting developmental changes in internalizing symptoms: examining the interplay between parenting and neuroendocrine stress reactivity. Developmental Psychobiology, 56, 908–923. doi:10.​1002/​dev.​21166.CrossRefPubMed
go back to reference Kuhlman, K. R., Vargas, I., Geiss, E. G., & Lopez-Duran, N. L. (2015). Age of trauma onset and HPA Axis dysregulation among trauma-exposed youth. Journal of Traumatic Stress, 28. doi:10.1002/jts.22054/full. Kuhlman, K. R., Vargas, I., Geiss, E. G., & Lopez-Duran, N. L. (2015). Age of trauma onset and HPA Axis dysregulation among trauma-exposed youth. Journal of Traumatic Stress, 28. doi:10.​1002/​jts.​22054/​full.
go back to reference Lansford, J. E., Dodge, K. A., Pettit, G. S., Bates, J. E., Crozier, J., & Kaplow, J. (2002). A 12-year prospective study of the long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence. Archives of Pediatrics and Adolescent Medicine, 156, 824–830.CrossRefPubMedPubMedCentral Lansford, J. E., Dodge, K. A., Pettit, G. S., Bates, J. E., Crozier, J., & Kaplow, J. (2002). A 12-year prospective study of the long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence. Archives of Pediatrics and Adolescent Medicine, 156, 824–830.CrossRefPubMedPubMedCentral
go back to reference McLaughlin, K. A., Sheridan, M. A., Tibu, F., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2015). Causal effects of the early caregiving environment on development of stress response systems in children. Proceedings of the National Academy of Sciences, 112, 5637–5642. doi:10.1073/pnas.1423363112.CrossRef McLaughlin, K. A., Sheridan, M. A., Tibu, F., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2015). Causal effects of the early caregiving environment on development of stress response systems in children. Proceedings of the National Academy of Sciences, 112, 5637–5642. doi:10.​1073/​pnas.​1423363112.CrossRef
go back to reference Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916–931. doi:10.1016/S0306-4530(02)00108-7.CrossRefPubMed Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916–931. doi:10.​1016/​S0306-4530(02)00108-7.CrossRefPubMed
go back to reference Steeger, C. M., Cook, E. C., & Connell, C. M. (2016). The interactive effects of stressful family life events and cortisol reactivity on adolescent externalizing and internalizing behaviors. Child Psychiatry and Human Development. doi:10.1007/s10578-016-0635-6. Steeger, C. M., Cook, E. C., & Connell, C. M. (2016). The interactive effects of stressful family life events and cortisol reactivity on adolescent externalizing and internalizing behaviors. Child Psychiatry and Human Development. doi:10.​1007/​s10578-016-0635-6.
go back to reference Sterba, S. K., Prinstein, M. J., & Cox, M. J. (2007). Trajectories of internalizing problems across childhood: heterogeneity, external validity, and gender differences. Development and Psychopathology, 19, 345–366. doi:10.1017/S0954579407070174.CrossRefPubMed Sterba, S. K., Prinstein, M. J., & Cox, M. J. (2007). Trajectories of internalizing problems across childhood: heterogeneity, external validity, and gender differences. Development and Psychopathology, 19, 345–366. doi:10.​1017/​S095457940707017​4.CrossRefPubMed
go back to reference Suomi, S. J. (1997). Early determinants of behaviour: evidence from primate studies. British Medical Bulletin, 53, 170–184.CrossRefPubMed Suomi, S. J. (1997). Early determinants of behaviour: evidence from primate studies. British Medical Bulletin, 53, 170–184.CrossRefPubMed
go back to reference Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016). The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews Neuroscience, 17, 652–666. doi:10.1038/nrn.2016.111.CrossRefPubMed Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016). The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews Neuroscience, 17, 652–666. doi:10.​1038/​nrn.​2016.​111.CrossRefPubMed
Metagegevens
Titel
HPA-Axis Activation as a Key Moderator of Childhood Trauma Exposure and Adolescent Mental Health
Auteurs
Kate R. Kuhlman
Elisa G. Geiss
Ivan Vargas
Nestor Lopez-Duran
Publicatiedatum
18-02-2017
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 1/2018
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-017-0282-9

Andere artikelen Uitgave 1/2018

Journal of Abnormal Child Psychology 1/2018 Naar de uitgave