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Gepubliceerd in: Research on Child and Adolescent Psychopathology 2/2016

24-02-2015

Stimulus-Driven Attention, Threat Bias, and Sad Bias in Youth with a History of an Anxiety Disorder or Depression

Auteurs: Chad M. Sylvester, James J. Hudziak, Michael S. Gaffrey, Deanna M. Barch, Joan L. Luby

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 2/2016

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Abstract

Attention biases towards threatening and sad stimuli are associated with pediatric anxiety and depression, respectively. The basic cognitive mechanisms associated with attention biases in youth, however, remain unclear. Here, we tested the hypothesis that threat bias (selective attention for threatening versus neutral stimuli) but not sad bias relies on stimulus-driven attention. We collected measures of stimulus-driven attention, threat bias, sad bias, and current clinical symptoms in youth with a history of an anxiety disorder and/or depression (ANX/DEP; n = 40) as well as healthy controls (HC; n = 33). Stimulus-driven attention was measured with a non-emotional spatial orienting task, while threat bias and sad bias were measured at a short time interval (150 ms) with a spatial orienting task using emotional faces and at a longer time interval (500 ms) using a dot-probe task. In ANX/DEP but not HC, early attention bias towards threat was negatively correlated with later attention bias to threat, suggesting that early threat vigilance was associated with later threat avoidance. Across all subjects, stimulus-driven orienting was not correlated with early threat bias but was negatively correlated with later threat bias, indicating that rapid stimulus-driven orienting is linked to later threat avoidance. No parallel relationships were detected for sad bias. Current symptoms of depression but not anxiety were related to decreased stimulus-driven attention. Together, these results are consistent with the hypothesis that threat bias but not sad bias relies on stimulus-driven attention. These results inform the design of attention bias modification programs that aim to reverse threat biases and reduce symptoms associated with pediatric anxiety and depression.
Literatuur
go back to reference Amir, N., Elias, J., Klumpp, H., & Przeworski, A. (2003). Attentional bias to threat in social phobia: facilitated processing of threat or difficulty disengaging attention from threat? Behaviour Research and Therapy, 41, 1325–1335.CrossRefPubMed Amir, N., Elias, J., Klumpp, H., & Przeworski, A. (2003). Attentional bias to threat in social phobia: facilitated processing of threat or difficulty disengaging attention from threat? Behaviour Research and Therapy, 41, 1325–1335.CrossRefPubMed
go back to reference Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin, 133, 1–24. doi:10.1037/0033-2909.133.1.1.CrossRefPubMed Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin, 133, 1–24. doi:10.​1037/​0033-2909.​133.​1.​1.CrossRefPubMed
go back to reference Bradley, B. P., Mogg, K., & Lee, S. C. (1997). Attentional biases for negative information in induced and naturally occurring dysphoria. Behaviour Research and Therapy, 35, 911–927.CrossRefPubMed Bradley, B. P., Mogg, K., & Lee, S. C. (1997). Attentional biases for negative information in induced and naturally occurring dysphoria. Behaviour Research and Therapy, 35, 911–927.CrossRefPubMed
go back to reference Brown, H. M., McAdams, T. A., Lester, K. J., Goodman, R., Clark, D. M., & Eley, T. C. (2013). Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders. Journal of Child Psychology and Psychiatry, 54, 678–685. doi:10.1111/jcpp.12024.CrossRefPubMed Brown, H. M., McAdams, T. A., Lester, K. J., Goodman, R., Clark, D. M., & Eley, T. C. (2013). Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders. Journal of Child Psychology and Psychiatry, 54, 678–685. doi:10.​1111/​jcpp.​12024.CrossRefPubMed
go back to reference Bruder, G. E., Kayser, J., Tenke, C. E., Leite, P., Schneier, F. R., Stewart, J. W., & Quitkin, F. M. (2002). Cognitive ERPs in depressive and anxiety disorders during tonal and phonetic oddball tasks. Clinical Electroencephalography, 33, 119–124.CrossRefPubMed Bruder, G. E., Kayser, J., Tenke, C. E., Leite, P., Schneier, F. R., Stewart, J. W., & Quitkin, F. M. (2002). Cognitive ERPs in depressive and anxiety disorders during tonal and phonetic oddball tasks. Clinical Electroencephalography, 33, 119–124.CrossRefPubMed
go back to reference Dalgleish, T., Taghavi, R., Neshat-Doost, H., Moradi, A., Canterbury, R., & Yule, W. (2003). Patterns of processing bias for emotional information across clinical disorders: a comparison of attention, memory, and prospective cognition in children and adolescents with depression, generalized anxiety, and posttraumatic stress disorder. Journal of Clinical Child and Adolescent Psychology, 32, 10–21. doi:10.1207/S15374424JCCP3201_02.CrossRefPubMed Dalgleish, T., Taghavi, R., Neshat-Doost, H., Moradi, A., Canterbury, R., & Yule, W. (2003). Patterns of processing bias for emotional information across clinical disorders: a comparison of attention, memory, and prospective cognition in children and adolescents with depression, generalized anxiety, and posttraumatic stress disorder. Journal of Clinical Child and Adolescent Psychology, 32, 10–21. doi:10.​1207/​S15374424JCCP320​1_​02.CrossRefPubMed
go back to reference Derryberry, D., & Reed, M. A. (2002). Anxiety-related attentional biases and their regulation by attentional control. Journal of Abnormal Psychology, 111, 225–236.CrossRefPubMed Derryberry, D., & Reed, M. A. (2002). Anxiety-related attentional biases and their regulation by attentional control. Journal of Abnormal Psychology, 111, 225–236.CrossRefPubMed
go back to reference Derryberry, D., & Rothbart, M. K. (1997). Reactive and effortful processes in the organization of temperament. Development and Psychopathology, 9, 633–652.CrossRefPubMed Derryberry, D., & Rothbart, M. K. (1997). Reactive and effortful processes in the organization of temperament. Development and Psychopathology, 9, 633–652.CrossRefPubMed
go back to reference Egger, H. L., Ascher, B., & Angold, A. (2003). The preschool age psychiatric assessment: Version 1.4. Durham: Duke University Medical Center. Egger, H. L., Ascher, B., & Angold, A. (2003). The preschool age psychiatric assessment: Version 1.4. Durham: Duke University Medical Center.
go back to reference Eldar, S., Apter, A., Lotan, D., Edgar, K. P., Naim, R., Fox, N. A., & Bar-Haim, Y. (2012). Attention bias modification treatment for pediatric anxiety disorders: a randomized controlled trial. The American Journal of Psychiatry, 169, 213–220.PubMedCentralCrossRefPubMed Eldar, S., Apter, A., Lotan, D., Edgar, K. P., Naim, R., Fox, N. A., & Bar-Haim, Y. (2012). Attention bias modification treatment for pediatric anxiety disorders: a randomized controlled trial. The American Journal of Psychiatry, 169, 213–220.PubMedCentralCrossRefPubMed
go back to reference Fox, E., Russo, R., Bowles, R., & Dutton, K. (2001). Do threatening stimuli draw or hold visual attention in subclinical anxiety? Journal of Experimental Psychology: General, 130, 681–700.CrossRef Fox, E., Russo, R., Bowles, R., & Dutton, K. (2001). Do threatening stimuli draw or hold visual attention in subclinical anxiety? Journal of Experimental Psychology: General, 130, 681–700.CrossRef
go back to reference Hankin, B. L., Gibb, B. E., Abela, J. R. Z., & Flory, K. (2010). Selective attention to affective stimuli and clinical depression among youths: role of anxiety and specificity of emotion. Journal of Abnormal Psychology, 119, 491–501. doi:10.1037/a0019609.PubMedCentralCrossRefPubMed Hankin, B. L., Gibb, B. E., Abela, J. R. Z., & Flory, K. (2010). Selective attention to affective stimuli and clinical depression among youths: role of anxiety and specificity of emotion. Journal of Abnormal Psychology, 119, 491–501. doi:10.​1037/​a0019609.PubMedCentralCrossRefPubMed
go back to reference Harrison, A. J., & Gibb, B. E. (2014). Attentional biases in currently depressed children: An eye-tracking study of biases in sustained attention to emotional stimuli. Journal of Clinical Child and Adolescent Psychology, 1–7. doi: 10.1080/15374416.2014.930688. Harrison, A. J., & Gibb, B. E. (2014). Attentional biases in currently depressed children: An eye-tracking study of biases in sustained attention to emotional stimuli. Journal of Clinical Child and Adolescent Psychology, 1–7. doi: 10.​1080/​15374416.​2014.​930688.
go back to reference In-Albon, T., Kossowsky, J., & Schneider, S. (2010). Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. Journal of Abnormal Child Psychology, 38, 225–235. doi:10.1007/s10802-009-9359-4.CrossRefPubMed In-Albon, T., Kossowsky, J., & Schneider, S. (2010). Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. Journal of Abnormal Child Psychology, 38, 225–235. doi:10.​1007/​s10802-009-9359-4.CrossRefPubMed
go back to reference Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry, 62, 593–602. doi:10.1001/archpsyc.62.6.593.CrossRefPubMed Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry, 62, 593–602. doi:10.​1001/​archpsyc.​62.​6.​593.CrossRefPubMed
go back to reference Koster, E. H., Crombez, G., Verschuere, B., Van Damme, S., & Wiersema, J. R. (2006). Components of attentional bias to threat in high trait anxiety: facilitated engagement, impaired disengagement, and attentional avoidance. Behaviour Research and Therapy, 44, 1757–1771. doi:10.1016/j.brat.2005.12.011.CrossRefPubMed Koster, E. H., Crombez, G., Verschuere, B., Van Damme, S., & Wiersema, J. R. (2006). Components of attentional bias to threat in high trait anxiety: facilitated engagement, impaired disengagement, and attentional avoidance. Behaviour Research and Therapy, 44, 1757–1771. doi:10.​1016/​j.​brat.​2005.​12.​011.CrossRefPubMed
go back to reference Koster, E. H., Baert, S., Bockstaele, M., & De Raedt, R. (2010). Attentional retraining procedures: manipulating early or late components of attentional bias? Emotion, 10, 230–236. doi:10.1037/a0018424.CrossRefPubMed Koster, E. H., Baert, S., Bockstaele, M., & De Raedt, R. (2010). Attentional retraining procedures: manipulating early or late components of attentional bias? Emotion, 10, 230–236. doi:10.​1037/​a0018424.CrossRefPubMed
go back to reference MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111, 107–123.CrossRefPubMed MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111, 107–123.CrossRefPubMed
go back to reference Merikangas, K. R., He, J.-P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., & Swendsen, J. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the national comorbidity survey replication--adolescent supplement (NCS-a). Journal of the American Academy of Child and Adolescent Psychiatry, 49, 980–989. doi:10.1016/j.jaac.2010.05.017.PubMedCentralCrossRefPubMed Merikangas, K. R., He, J.-P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., & Swendsen, J. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the national comorbidity survey replication--adolescent supplement (NCS-a). Journal of the American Academy of Child and Adolescent Psychiatry, 49, 980–989. doi:10.​1016/​j.​jaac.​2010.​05.​017.PubMedCentralCrossRefPubMed
go back to reference Mogg, K., Bradley, B. P., de Bono, J., & Painter, M. (1997). Time course of attentional bias for threat information in non-clinical anxiety. Behaviour Research and Therapy, 35, 297–303.CrossRefPubMed Mogg, K., Bradley, B. P., de Bono, J., & Painter, M. (1997). Time course of attentional bias for threat information in non-clinical anxiety. Behaviour Research and Therapy, 35, 297–303.CrossRefPubMed
go back to reference Mogg, K., Bradley, B. P., Miles, F., & Dixon, R. (2004). Time course of attentional bias for threat scenes: testing the vigilance-avoidance hypothesis. Cognition & Emotion, 18, 689–700.CrossRef Mogg, K., Bradley, B. P., Miles, F., & Dixon, R. (2004). Time course of attentional bias for threat scenes: testing the vigilance-avoidance hypothesis. Cognition & Emotion, 18, 689–700.CrossRef
go back to reference Mogg, K., Wilson, K. A., Hayward, C., Cunning, D., & Bradley, B. P. (2012). Attentional biases for threat in at-risk daughters and mothers with lifetime panic disorder. Journal of Abnormal Psychology, 121, 852–862. doi:10.1037/a0028052.CrossRefPubMed Mogg, K., Wilson, K. A., Hayward, C., Cunning, D., & Bradley, B. P. (2012). Attentional biases for threat in at-risk daughters and mothers with lifetime panic disorder. Journal of Abnormal Psychology, 121, 852–862. doi:10.​1037/​a0028052.CrossRefPubMed
go back to reference Mogoase, C., David, D., & Koster, E. H. (2014). Clinical efficacy of attentional bias modification procedures: an updated meta-analysis. Journal of Clinical Psychology. doi:10.1002/jclp.22081.PubMed Mogoase, C., David, D., & Koster, E. H. (2014). Clinical efficacy of attentional bias modification procedures: an updated meta-analysis. Journal of Clinical Psychology. doi:10.​1002/​jclp.​22081.PubMed
go back to reference Monk, C. S., Nelson, E. E., McClure, E. B., Mogg, K., Bradley, B. P., Leibenluft, E., & Pine, D. S. (2006). Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. The American Journal of Psychiatry, 163, 1091–1097. doi:10.1176/appi.ajp.163.6.1091.CrossRefPubMed Monk, C. S., Nelson, E. E., McClure, E. B., Mogg, K., Bradley, B. P., Leibenluft, E., & Pine, D. S. (2006). Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. The American Journal of Psychiatry, 163, 1091–1097. doi:10.​1176/​appi.​ajp.​163.​6.​1091.CrossRefPubMed
go back to reference Pérez-Edgar, K., Bar-Haim, Y., McDermott, J. M., Chronis-Tuscano, A., Pine, D. S., & Fox, N. A. (2010). Attention biases to threat and behavioral inhibition in early childhood shape adolescent social withdrawal. Emotion, 10, 349–357. doi:10.1037/a0018486.PubMedCentralCrossRefPubMed Pérez-Edgar, K., Bar-Haim, Y., McDermott, J. M., Chronis-Tuscano, A., Pine, D. S., & Fox, N. A. (2010). Attention biases to threat and behavioral inhibition in early childhood shape adolescent social withdrawal. Emotion, 10, 349–357. doi:10.​1037/​a0018486.PubMedCentralCrossRefPubMed
go back to reference Perez-Edgar, K., Reeb-Sutherland, B. C., McDermott, J. M., White, L. K., Henderson, H. A., Degnan, K. A., & Fox, N. A. (2011). Attention biases to threat link behavioral inhibition to social withdrawal over time in very young children. Journal of Abnormal Child Psychology, 39, 885–895. doi:10.1007/s10802-011-9495-5.PubMedCentralCrossRefPubMed Perez-Edgar, K., Reeb-Sutherland, B. C., McDermott, J. M., White, L. K., Henderson, H. A., Degnan, K. A., & Fox, N. A. (2011). Attention biases to threat link behavioral inhibition to social withdrawal over time in very young children. Journal of Abnormal Child Psychology, 39, 885–895. doi:10.​1007/​s10802-011-9495-5.PubMedCentralCrossRefPubMed
go back to reference Sanchez, A., Vazquez, C., Marker, C., LeMoult, J., & Joormann, J. (2013). Attentional disengagement predicts stress recovery in depression: an eye-tracking study. Journal of Abnormal Psychology, 122, 303–313. doi:10.1037/a0031529.CrossRefPubMed Sanchez, A., Vazquez, C., Marker, C., LeMoult, J., & Joormann, J. (2013). Attentional disengagement predicts stress recovery in depression: an eye-tracking study. Journal of Abnormal Psychology, 122, 303–313. doi:10.​1037/​a0031529.CrossRefPubMed
go back to reference Shechner, T., Britton, J. C., Pérez-Edgar, K., Bar-Haim, Y., Ernst, M., Fox, N. A., & Pine, D. S. (2012). Attention biases, anxiety, and development: toward or away from threats or rewards? Depression and Anxiety, 29, 282–294. doi:10.1002/da.20914.PubMedCentralCrossRefPubMed Shechner, T., Britton, J. C., Pérez-Edgar, K., Bar-Haim, Y., Ernst, M., Fox, N. A., & Pine, D. S. (2012). Attention biases, anxiety, and development: toward or away from threats or rewards? Depression and Anxiety, 29, 282–294. doi:10.​1002/​da.​20914.PubMedCentralCrossRefPubMed
go back to reference Shechner, T., Jarcho, J. M., Britton, J. C., Leibenluft, E., Pine, D. S., & Nelson, E. E. (2013). Attention bias of anxious youth during extended exposure of emotional face pairs: a eye-tracking study. Depression and Anxiety, 30, 14–21. doi:10.1002/da.21986.PubMedCentralCrossRefPubMed Shechner, T., Jarcho, J. M., Britton, J. C., Leibenluft, E., Pine, D. S., & Nelson, E. E. (2013). Attention bias of anxious youth during extended exposure of emotional face pairs: a eye-tracking study. Depression and Anxiety, 30, 14–21. doi:10.​1002/​da.​21986.PubMedCentralCrossRefPubMed
go back to reference Shechner, T., Rimon-Chakir, A., Britton, J. C., Lotan, D., Apter, A., Bliese, P. D., & Bar-Haim, Y. (2014). Attention bias modification treatment augmenting effects on cognitive behavioral therapy in children with anxiety: randomized controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 61–71. doi:10.1016/j.jaac.2013.09.016.PubMedCentralCrossRefPubMed Shechner, T., Rimon-Chakir, A., Britton, J. C., Lotan, D., Apter, A., Bliese, P. D., & Bar-Haim, Y. (2014). Attention bias modification treatment augmenting effects on cognitive behavioral therapy in children with anxiety: randomized controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 61–71. doi:10.​1016/​j.​jaac.​2013.​09.​016.PubMedCentralCrossRefPubMed
go back to reference Sylvester, C. M., Barch, D. M., Corbetta, M., Power, J. D., Schlaggar, B. L., & Luby, J. L. (2013). Resting state functional connectivity of the ventral attention network in children with a history of depression or anxiety. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1326–1336), e1325. doi:10.1016/j.jaac.2013.10.001. Sylvester, C. M., Barch, D. M., Corbetta, M., Power, J. D., Schlaggar, B. L., & Luby, J. L. (2013). Resting state functional connectivity of the ventral attention network in children with a history of depression or anxiety. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1326–1336), e1325. doi:10.​1016/​j.​jaac.​2013.​10.​001.
go back to reference Taghavi, M. R., Neshat-Doost, H. T., Moradi, A. R., Yule, W., & Dalgleish, T. (1999). Biases in visual attention in children and adolescents with clinical anxiety and mixed anxiety-depression. Journal of Abnormal Child Psychology, 27, 215–223.CrossRefPubMed Taghavi, M. R., Neshat-Doost, H. T., Moradi, A. R., Yule, W., & Dalgleish, T. (1999). Biases in visual attention in children and adolescents with clinical anxiety and mixed anxiety-depression. Journal of Abnormal Child Psychology, 27, 215–223.CrossRefPubMed
go back to reference Vasey, M. W., Daleiden, E. L., Williams, L. L., & Brown, L. M. (1995). Biased attention in childhood anxiety disorders: a preliminary study. Journal of Abnormal Child Psychology, 23, 267–279.CrossRefPubMed Vasey, M. W., Daleiden, E. L., Williams, L. L., & Brown, L. M. (1995). Biased attention in childhood anxiety disorders: a preliminary study. Journal of Abnormal Child Psychology, 23, 267–279.CrossRefPubMed
go back to reference Vervoort, L., Wolters, L. H., Hogendoorn, S. M., Prins, P. J., de Haan, E., Boer, F., & Hartman, C. A. (2011). Temperament, attentional processes, and anxiety: diverging links between adolescents with and without anxiety disorders? Journal of Clinical Child and Adolescent Psychology, 40, 144–155. doi:10.1080/15374416.2011.533412.CrossRefPubMed Vervoort, L., Wolters, L. H., Hogendoorn, S. M., Prins, P. J., de Haan, E., Boer, F., & Hartman, C. A. (2011). Temperament, attentional processes, and anxiety: diverging links between adolescents with and without anxiety disorders? Journal of Clinical Child and Adolescent Psychology, 40, 144–155. doi:10.​1080/​15374416.​2011.​533412.CrossRefPubMed
go back to reference Waters, A. M., Mogg, K., Bradley, B. P., & Pine, D. S. (2008). Attentional bias for emotional faces in children with generalized anxiety disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 435–442. doi:10.1097/CHI.0b013e3181642992.CrossRefPubMed Waters, A. M., Mogg, K., Bradley, B. P., & Pine, D. S. (2008). Attentional bias for emotional faces in children with generalized anxiety disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 435–442. doi:10.​1097/​CHI.​0b013e3181642992​.CrossRefPubMed
go back to reference Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive Psychology and Emotional Disorders (2nd ed.). Chichester: Wiley. Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive Psychology and Emotional Disorders (2nd ed.). Chichester: Wiley.
Metagegevens
Titel
Stimulus-Driven Attention, Threat Bias, and Sad Bias in Youth with a History of an Anxiety Disorder or Depression
Auteurs
Chad M. Sylvester
James J. Hudziak
Michael S. Gaffrey
Deanna M. Barch
Joan L. Luby
Publicatiedatum
24-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 2/2016
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-015-9988-8

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