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The Clinical Picture of Uncomplicated Versus Complicated Diverticulitis of the Colon

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Abstract

Purpose There is no consensus about the correct definition of uncomplicated diverticulitis (UD) in clinical practice. We evaluated therefore whether clinical picture of UD differs from complicated diverticulitis (CD). Fifty consecutive eligible patients (21 males, 29 females, mean age 63.6 years, range 47–75 years) were studied. Symptoms, the inflammatory indices, and Computerized Tomography (CT) scan of the abdomen were assessed at the time of admission. Results Thirty-nine patients classified were affected by UD and 11 patients by CD. CD patients showed more severe clinical picture than UD and required urgent Hospital admission. Conversely, most of the patients affected by UD were treated as outpatients. CD patients showed higher symptom scores than UD patients, except the parameter “diarrhea”. All CD patients showed increases in all inflammatory indices. Conversely, all UD patients showed increased ESR, CRP and fibrinogen, but WBC and α1-acid glycoprotein were increased in only a few cases. CT scan in CD patients always showed signs of severe colonic and pericolonic inflammation. Conversely, UD patients often showed moderate localized signs of inflammation without complication. Conclusions Clinical, laboratory, and radiological findings may easily differentiate uncomplicated from complicated diverticulitis of the colon. This integrated approach may be helpful in clinical settings.

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References

  1. Almy TP, Howell DA (1980) Diverticular disease of the colon. N Engl J Med 302:324–331

    Article  PubMed  CAS  Google Scholar 

  2. Painter NS, Burkitt DP (1971) Diverticular disease of the colon: a deficiency disease of western civilization. Br Med J 2:450–454

    Article  PubMed  CAS  Google Scholar 

  3. Parks TG (1975) Natural history of diverticular disease of the colon. Clin Gastroenterol 4:53–69

    PubMed  CAS  Google Scholar 

  4. Painter NS, Burkitt DP (1975) Diverticular disease of the colon, a 20th century problem. Clin Gastroenterol 4:3–21

    PubMed  CAS  Google Scholar 

  5. Berman LG, Burdick D, Heitzman ER, Prior JT (1968) A critical reappraisal of sigmoid peridiverticulitis. Surg Gyn Obstet 127:481–491

    CAS  Google Scholar 

  6. Williams RA, Davis IP (1995) Diverticular disease of the colon. In: Haubrich WS, Schaffner F (eds) Bockus gastroenterology, 5th edn. Saunders, Philadelphia, pp 1637–1656

    Google Scholar 

  7. Results of a Consensus Development Conference (1999) Diagnosis and treatment of diverticular disease. Surg Endosc 3:430–436

    Google Scholar 

  8. Ghorai S, Ulbright TM, Rex DK (2003) Endoscopic findings of diverticular inflammation in colonoscopy patients without clinical acute diverticulitis: prevalence and endoscopic spectrum. Am J Gastroenterol 98:802–806

    Article  PubMed  Google Scholar 

  9. Tursi A, Brandimarte G, Daffinà R (2002) Long-term treatment with mesalazine and rifaximin versus rifaximin alone for the patients with recurrent attacks of acute diverticulitis of the colon. Digest Liver Dis 34:510–515

    Article  CAS  Google Scholar 

  10. Tursi A, Brandimarte G, Giorgetti GM, Elisei W (2006) Mesalazine and/or Lactobacillus casei in preventing recurrence of symptomatic uncomplicated diverticular disease of the colon: a prospective, randomised, open-label study. J Clin Gastroenterol 40:312–316

    Article  PubMed  Google Scholar 

  11. Narayan R, Floch MH (2002) Microscopic colitis as part of the natural history of diverticular disease (Abstract). Am J Gastroenterol 97(suppl):112

    Article  Google Scholar 

  12. Morini S, Hassan C, Zullo A, De Francesco V, Burattini O, Margiotta M, Panella C, Ierardi E (2005) Epithelial cell proliferation of the colonic mucosa in diverticular disease: a case–control study. Aliment Pharmacol Ther 21:1385–1390

    Article  PubMed  CAS  Google Scholar 

  13. Tursi A, Brandimarte G, Elisei W, Inchingolo CD, Aiello F (2006) Epithelial cell proliferation of the colonic mucosa in different degrees of colonic diverticular disease. J Clin Gastroenterol 40:306–311

    Article  PubMed  Google Scholar 

  14. Tursi A (2004) Acute diverticulitis of the colon—Current medical therapeutic management. Exp Opin Pharmacother 51:145–149

    Google Scholar 

  15. Tursi A (2005) Mesalazine for diverticular disease of the colon—a new role for an old drug. Exp Opin Pharmacother 6:69–74

    Article  CAS  Google Scholar 

  16. Tursi A (2007) New physiopathologic and therapeutic approach to diverticular disease of the colon. Exp Opin Pharmacother 8:299–307

    Article  CAS  Google Scholar 

  17. Pereira JM, Sirlin CB, Pinto PS, Jeffrey RB, Stella DL, Casola G (2004) Disproportionate fat stranding: a helpful CT sign in patients with acute abdominal pain. RadioGraphics 24:703–715

    Article  PubMed  Google Scholar 

  18. Jang H-J, Lim HK, Lee SJ, Lee WJ, Kim EY, Kim SH (2000) Acute diverticulitis of the cecum and ascending colon. The value of thin-section helical CT findings in excluding colonic carcinoma. Am J Roentgenol 174:1397–1402

    CAS  Google Scholar 

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Tursi, A., Brandimarte, G., Giorgetti, G. et al. The Clinical Picture of Uncomplicated Versus Complicated Diverticulitis of the Colon. Dig Dis Sci 53, 2474–2479 (2008). https://doi.org/10.1007/s10620-007-0161-2

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  • DOI: https://doi.org/10.1007/s10620-007-0161-2

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