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01-02-2010 | Original Article

The Role of Cognitive-Behavioral Therapy and Fluoxetine in Prevention of Recurrence of Major Depressive Disorder

Auteurs: Timothy J. Petersen, Joel A. Pava, Jacqueline Buchin, John D. Matthews, George I. Papakostas, Andrew A. Nierenberg, Avram J. Holmes, Ryan Bogdan, Lesley M. Graves, Rebecca M. Harley, Maurizio Fava

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 1/2010

Abstract

This study evaluated the role of cognitive-behavioral therapy (CBT) and fluoxetine in preventing recurrence of a depressive episode during maintenance phase treatment for patients with remitted major depressive disorder (MDD). Patients (n = 52) completed open acute fluoxetine treatment and sustained remission during a 28-week randomized continuation treatment (CBT + fluoxetine vs. fluoxetine only). They were assigned to one of four maintenance treatments: CBT + fluoxetine, CBT + placebo, fluoxetine only, and placebo only. There were no statistically significant differences in MDD recurrence between maintenance treatments, but continued antidepressant treatment (with or without CBT) provided an 18–21% lower MDD recurrence rate than placebo. These findings are consistent with those of recent antidepressant studies of chronic and recurrent MDD populations. Although sample sizes were small, CBT did not significantly lower rates of MDD recurrence.

vorige artikel Automatic Thoughts and Cognitive Restructuring in Cognitive Behavioral Group Therapy for Social Anxiety Disorder

volgende artikel Dysfunctional Attitudes, Attributional Styles, and Phase of Illness in Bipolar Disorder

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Titel: The Role of Cognitive-Behavioral Therapy and Fluoxetine in Prevention of Recurrence of Major Depressive Disorder
Auteurs: Timothy J. Petersen
Joel A. Pava
Jacqueline Buchin
John D. Matthews
George I. Papakostas
Andrew A. Nierenberg
Avram J. Holmes
Ryan Bogdan
Lesley M. Graves
Rebecca M. Harley
Maurizio Fava
Publicatiedatum: 01-02-2010
Uitgeverij: Springer US
Gepubliceerd in: Cognitive Therapy and Research / Uitgave 1/2010
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI: https://doi.org/10.1007/s10608-007-9166-6

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