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Prognostic value of absence or presence of coronary artery disease determined by 64-slice computed tomography coronary angiography A systematic review and meta-analysis

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Abstract

To determine via a meta-analysis the prognostic value of 64-slice computed tomography angiography (CTA) by quantifying risk of major adverse cardiac events (MACE) in different patient groups classified according to CT angiographic findings. A systematic literature search and meta-analyses was conducted on 10 studies examining stable, symptomatic and intermediate risk patients by 64-slice CTA. Patients were followed up for a mean of 21 month. Patient groups with CT-angiographic non-obstructive (stenosis <50% of luminal narrowing) or obstructive (stenosis ≥50% of luminal narrowing) CAD were compared to those having normal angiography without CAD. MACE (cardiac death, non-fatal myocardial infarction and revascularization) numbers were used to calculate odds ratios (OR) with 95% confidence interval (CI) in each group. Ten studies including 5,675 patients were eligible for meta-analysis. The cumulative MACE rate over 21 months were 0.5% in patients with normal CTA, 3.5% in non-obstructive CAD and 16% in obstructive CAD. Compared to normal CTA, non-obstructive CAD was associated with significant increased risk of MACE with OR = 6.68 (3.01–14.82 CI 95%), P = 0.0001. Obstructive CAD was associated with further significant increased risk of MACE with OR = 41.19 (22.56–75.18, CI 95%), P = 0.0001. The studies were homogenous, P-value >0.05 for heterogeneity. 64-slice CTA is able to differentiate low-risk from high-risk patients with suspected or known CAD. Absence of CAD predicts excellent prognosis, while obstructive CAD is associated with markedly increased risk of MACE.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Glostrup University Hospital, Copenhagen, Denmark

    Jawdat Abdulla & Camilla Asferg

  2. Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Klaus Fuglsang Kofoed

  3. Lyovej 18, 3.TV, DK-2000, Frederiksberg, Denmark

    Jawdat Abdulla

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  1. Jawdat Abdulla
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  2. Camilla Asferg
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  3. Klaus Fuglsang Kofoed
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Correspondence to Jawdat Abdulla.

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Abdulla, J., Asferg, C. & Kofoed, K.F. Prognostic value of absence or presence of coronary artery disease determined by 64-slice computed tomography coronary angiography A systematic review and meta-analysis. Int J Cardiovasc Imaging 27, 413–420 (2011). https://doi.org/10.1007/s10554-010-9652-x

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  • DOI: https://doi.org/10.1007/s10554-010-9652-x

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