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Vessel masking improves densitometric myocardial perfusion assessment

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Abstract

Introduction The objective of treatment in acute myocardial infarction (AMI) is reperfusion of the myocardium at risk. Our goal was to evaluate the effect of vessel masking on videodensitometric assessment of myocardial reperfusion. Methods Epicardial vessels were masked out from the densitometric region of interest, where average rise slope (G max/T max) of time–density curves (TDC) were measured. Measurements were tested to detect indicators of reperfusion as cumulative creatine-kinase (CK) release and ST-resolution by receiver operating characteristic (ROC) curve analysis. Results When vessel masking was applied before G max/T max measurement, an improvement has been observed in sensitivity and area under ROC curve to detect indicators of reperfusion as cumulative enzyme release (sensitivity (Se): 85% vs. 61%, area under the curve (AUC): 0.84 vs. 0.76) and ST-resolution (Se: 74% vs. 67%, AUC: 0.83 vs. 0.79). Conclusions Selective myocardial perfusion measurement on coronary angiograms is feasible and serves as an informative method to detect myocardial viability after AMI and revascularization therapy. The present study demonstrated that vessel masking improves results compared to simple densitometric analysis.

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Acknowledgements

This study was financially supported by the Regional Cooperative Research Center of Life and Material Sciences of the University of Szeged (DEAK) and GE Healthcare, Hungary. Dr. Tamás Ungi holds a PhD scholarship of the University of Szeged.

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Authors and Affiliations

  1. Department of Radiology, Medical Faculty, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary

    Tamás Ungi & András Palkó

  2. 2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Korányi fasor 6, P.O. Box 427, 6720, Szeged, Hungary

    Zsolt Zimmermann, Erika Balázs, Imre Ungi, Tamás Forster & Attila Nemes

  3. General Electric Healthcare, Budaörs, Hungary

    András Lassó

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  1. Tamás Ungi
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  2. Zsolt Zimmermann
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Correspondence to Attila Nemes.

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Ungi, T., Zimmermann, Z., Balázs, E. et al. Vessel masking improves densitometric myocardial perfusion assessment. Int J Cardiovasc Imaging 25, 229–236 (2009). https://doi.org/10.1007/s10554-008-9374-5

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  • DOI: https://doi.org/10.1007/s10554-008-9374-5

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