Abstract
We examined cardiorespiratory fitness (CRF) levels in early stage breast cancer patients and determined whether CRF differs as a function of adjuvant therapy regimen. A total of 180 early breast cancer patients representing three treatment groups (surgery only, single-, and multi-modality adjuvant therapy) in the Cooper Center Longitudinal Study (CCLS) were studied. A non-cancer control group (n = 180) matched by sex, age, and date of the CCLS visit was included. All subjects underwent an incremental exercise tolerance test to symptom limitation to assess CRF (i.e., peak metabolic equivalents [METs] and time to exhaustion). The mean time from breast cancer diagnosis to exercise tolerance testing was 7.4 ± 6.2 years. In adjusted analyses, time to exhaustion and peak METs were incrementally impaired with the addition of surgery, single-, and multi-modality adjuvant therapy compared to those of matched controls (p = 0.006 and 0.028, respectively). CRF was lowest in the multi-modality group compared to all other groups (all p’s < 0.05). Despite being 7 years post-diagnosis, asymptomatic early breast cancer survivors have marked reductions in CRF. Patients treated with multi-modal adjuvant therapy have the greatest impairment in CRF.
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Abbreviations
- CVD:
-
Cardiovascular disease
- CCLS:
-
Cooper Center Longitudinal Study
- METs:
-
Metabolic equivalents
- LVEF:
-
Left ventricular ejection fraction
- CRF:
-
Cardiorespiratory fitness
- ECG:
-
Electrocardiogram
- ANCOVA:
-
Analysis of covariance
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Acknowledgments
LWJ is supported in part by Research Grants from the National Cancer Institute (CA143254, CA142566, CA138634, CA133895, CA164751).
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Lakoski, S.G., Barlow, C.E., Koelwyn, G.J. et al. The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. Breast Cancer Res Treat 138, 909–916 (2013). https://doi.org/10.1007/s10549-013-2478-1
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DOI: https://doi.org/10.1007/s10549-013-2478-1