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Impact of multiple caregiving roles on elevated depressed mood in early-stage breast cancer patients and same-age controls

  • Epidemiology
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Abstract

The effect of caregiving roles on risk of elevated depressed mood over 12 months was examined in early-stage (0–IIA) breast cancer patients and same-aged women without breast cancer. Women were interviewed 4–6 weeks, 6 months, and 12 months following definitive surgical treatment (patients) or routine screening mammogram (controls). The Center for Epidemiologic Studies-Depression Scale was administered at each interview and dichotomized for analysis (<16 [little/no depressed mood] vs. ≥16 [elevated depressed mood]). Participants were categorized as having no caregiving responsibilities, caregiving for children or other persons, or caregiving for both children and others (multiple caregiving roles). Two multivariable marginal logistic regression models with repeated measures were fit (one each for patients and controls) to examine the effect of caregiving roles on elevated depressed mood, using generalized estimating equations to account for intra-individual correlations. Of 1096 participants (mean age 58; 76% white), 1019 with caregiving data were included in the analysis. Compared with baseline, patients with multiple caregiving roles (23/521 patients) were at increased risk of elevated depressed mood at 6 months (adjusted odds ratio [aOR], 7.20; 95% confidence interval [CI], 1.17–44.46; P = 0.034), and controls with multiple caregiving roles (15/498 controls) were at decreased risk of elevated depressed mood at 12-month follow-up (aOR, 0.12; 95% CI, 0.02–0.97; P = 0.047). Patients with multiple caregiving roles were more likely while controls were less likely to report elevated depressed mood over time, suggesting a need to identify patients with multiple caregiving roles early during their treatment.

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Acknowledgments

This study was supported by a grant from the National Cancer Institute and Breast Cancer Stamp Fund (#R01CA102777) and by the National Cancer Institute Cancer Center Support Grant (#P30 CA91842) to the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, Missouri. We thank our participants, interviewers, and Siteman Cancer Center’s Health Behavior and Outreach Core and Biostatistics Core for data management and statistical services. We also thank the many physicians who helped us recruit their patients for this study, including Drs. Barbara Monsees, Jill Dietz, Julie Margenthaler, Virginia Herrmann, Timothy Eberlein, Matthew Ellis, Imran Zoberi, Marie Taylor, Michael Naughton, Antonella Rastelli, Donald Lombardi, Cynthia Ma, Loren Michel, and Rama Suresh at Washington University School of Medicine and Dr. Eddie Hsueh and Pam Hunborg, RN, at Saint Louis University School of Medicine.

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Authors and Affiliations

  1. Department of Surgery, Vanderbilt University, Nashville, TN, USA

    Ellen H. Bailey

  2. Department of Medicine, Washington University School of Medicine, 4444 Forest Park Ave, Suite 6700, St. Louis, MO, 63108, USA

    Maria Pérez, Mario Schootman & Donna B. Jeffe

  3. Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA

    Rebecca L. Aft & Ying Liu

  4. Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO, USA

    Rebecca L. Aft, Mario Schootman & Donna B. Jeffe

  5. John Cochran Veterans Administration Hospital, St. Louis, MO, USA

    Rebecca L. Aft

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  1. Ellen H. Bailey
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  2. Maria Pérez
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  6. Donna B. Jeffe
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Correspondence to Donna B. Jeffe.

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Bailey, E.H., Pérez, M., Aft, R.L. et al. Impact of multiple caregiving roles on elevated depressed mood in early-stage breast cancer patients and same-age controls. Breast Cancer Res Treat 121, 709–718 (2010). https://doi.org/10.1007/s10549-009-0645-1

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  • DOI: https://doi.org/10.1007/s10549-009-0645-1

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