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Estimating the Roles of Genetic Risk, Perinatal Risk, and Marital Hostility on Early Childhood Adjustment: Medical Records and Self-Reports

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Abstract

A wide variety of perinatal risk factors have been linked to later developmental outcomes in children. Much of this work has relied on either birth/medical records or mothers’ self-reports collected after delivery, and there has been an ongoing debate about which strategy provides the most accurate and reliable data. This report uses a parent-offspring adoption design (N = 561 families) to (1) examine the correspondence between medical record data and self-report data, (2) examine how perinatal risk factors may influence child internalizing and externalizing behavior at age 4.5 years, and (3) explore interactions among genetic, perinatal risk, and rearing environment on child internalizing and externalizing behavior during early childhood. The agreement of self-reports and medical records data was relatively high (51–100 %), although there was some variation based on the construct. There were few main effects of perinatal risk on child outcomes; however, there were several 2- and 3-way interactions suggesting that the combined influences of genetic, perinatal, and rearing environmental risks are important, particularly for predicting whether children exhibit internalizing versus externalizing symptoms at age 4.5 years.

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Acknowledgments

This project was supported by R01DA020585 from NIDA, NIMH, and OBSSR, NIH, U.S. PHS (PI: Jenae Neiderhiser); R01HD042608 from NICHD, NIDA, and OBSSR, NIH, U.S. PHS (PI Years 1–5: David Reiss; PI Years 6–10: Leslie Leve); and R01MH092118 (PIs: Jenae Neiderhiser and Leslie Leve) from NIMH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development or the National Institutes of Health. We gratefully acknowledge Rand Conger and Laura Scaramella who contributed to the larger study. Special thanks go to Drs. Xiaojia Ge, Beverly Fagot and John Reid, who contributed to the design and execution of the EGDS study prior to their deaths.

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Authors and Affiliations

  1. Department of Psychology, Penn State University, 141 Moore Building, University Park, PA, 16802, USA

    Jenae M. Neiderhiser & Marielena De Araujo-Greecher

  2. Center for Alcohol and Addiction Studies, Department of Behavioral & Social Sciences, Brown University School of Public Health, Providence, RI, USA

    Kristine Marceau

  3. Division of Behavior Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA

    Kristine Marceau

  4. Department of Psychology, George Washington University, Washington, DC, USA

    Jody M. Ganiban

  5. Child Psychiatry, Pediatrics, and Psychology, Yale Child Study Center, New Haven, CT, USA

    Linda C. Mayes

  6. Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel S. Shaw

  7. Yale Child Study Center, New Haven, CT, USA

    David Reiss

  8. Counseling Psychology and Human Services, Prevention Science Institute, University of Oregon, Eugene, OR, USA

    Leslie D. Leve

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  1. Jenae M. Neiderhiser
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Correspondence to Jenae M. Neiderhiser.

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Jenae M. Neiderhiser, Kristine Marceau, Marielena De Araujo-Greecher, Jody M. Ganiban, Linda C. Mayes, Daniel S. Shaw, David Reiss, and Leslie D. Leve declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all participants included in the study.

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Neiderhiser, J.M., Marceau, K., De Araujo-Greecher, M. et al. Estimating the Roles of Genetic Risk, Perinatal Risk, and Marital Hostility on Early Childhood Adjustment: Medical Records and Self-Reports. Behav Genet 46, 334–352 (2016). https://doi.org/10.1007/s10519-016-9788-0

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