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No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

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Abstract

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)—and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

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Acknowledgments

We thank the participants and their families for their cooperation. Australian data collection was funded by ARC grants (A79600334, A79906588, A79801419, DP0212016, DP0343921) and the Human Frontiers of Science Program (HFSP; Grant rg0154/1998-B). Blood collection and DNA extraction for the Dyne Steele cohort was partly funded by Research into Ageing. The AAA Trial is funded by the Wellcome Trust, British Heart Foundation and Chief Scientist Office of the Scottish Executive. SHE, IJD and JFP are members of the University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology part of the UK’s cross council Lifelong Health and Wellbeing Initiative; funding from the BBSRC, EPSRC, ESRC and MRC is gratefully acknowledged.

Conflict of interest statement

The authors report no biomedical financial interests or potential conflicts of interest.

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Authors and Affiliations

  1. Genetic Epidemiology Unit, PO Royal Brisbane Hospital, Brisbane, QLD, 4029, Australia

    Penelope A. Lind, Michelle Luciano, Margaret J. Wright & Nicholas G. Martin

  2. Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK

    Michelle Luciano, Timothy C. Bates, Sarah E. Harris & Ian J. Deary

  3. Clinical Gerontology, Hope Hospital, University of Manchester, Clinical Sciences Building, Stott Lane, Salford, Greater Manchester, M6 8HD, UK

    Michael A. Horan, Yvonne Davidson, Linda Gibbons & Neil Pendleton

  4. Division of Community Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK

    Riccardo E. Marioni & Jackie F. Price

  5. Age and Cognitive Performance Research Centre, University of Manchester, Zochonis Building, Oxford Road, Manchester, M13 9PL, UK

    Patrick Rabbitt & Andrew Pickles

  6. Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh, Edinburgh, UK

    Sarah E. Harris

  7. Biostatistics Group, University of Manchester, Stopford Building, Manchester, M13 9PT, UK

    William Ollier

  8. Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Antony Payton

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  1. Penelope A. Lind
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Correspondence to Penelope A. Lind.

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The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.

Edited by Chandra A. Reynolds.

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Lind, P.A., Luciano, M., Horan, M.A. et al. No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples. Behav Genet 39, 513–523 (2009). https://doi.org/10.1007/s10519-009-9274-z

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