Abstract
The HIV epidemic in Latin America is highly concentrated in men who have sex with men (MSM). In the United States, multiple co-occurring psychosocial conditions have been shown to act as intertwined epidemics to potentiate HIV transmission among MSM. To date, no study has examined the role of syndemics and condomless sex among MSM in Latin America. In 2012, an online survey was conducted among members of the largest social/sexual networking website for MSM in Latin America. Participants were asked about demographics, sexual behaviors, HIV/STI diagnoses, and psychosocial well-being, including depression, suicidal ideation, hazardous alcohol use, hard drug use during sex, history of childhood/adolescent sexual abuse, intimate partner violence, and sexual compulsivity. Multivariable logistic generalized estimation equations were used to assess the relationship of syndemic factors and (1) engagement in higher risk condomless anal sex and (2) self-report of prior HIV diagnosis. Among 24,274 survey respondents, 74.6 % of the sample had at least one syndemic factor. In an additive model, syndemics were associated with increased odds of higher risk condomless anal sex, ranging from adjusted odds ratio of 1.31 (95 % CI 1.20, 1.43) for one syndemic factor to 4.06 (95 % CI 3.25, 5.09) for 6/7 syndemic factors. Similarly, syndemics were associated with increased odds of HIV infection (p < .0001). This study provides initial evidence that intertwined syndemics increase HIV risk behavior and HIV infection among MSM in Latin America. In the Latin American context, comprehensive HIV prevention interventions for MSM should be developed and tested that simultaneously address co-occurring psychosocial conditions and HIV risk.
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Andresen, E. M., Malmgren, J. A., Carter, W. B., & Patrick, D. L. (1994). Screening for depression in well older adults: Evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). American Journal of Preventive Medicine, 10, 77–84.
Ayala, G., Makofane, K., Santos, G.M., Beck, J., Do, T. D., Herbert, P., et al. (2013). Access to basic HIV-related services and PrEP acceptability among men who have sex with men worldwide: Barriers, facilitators, and implications for combination prevention. Journal of Sexually Transmitted Diseases. doi:10.1155/2013/953123.
Ballester-Arnal, R., Gomez-Martinez, S., Llario, M. D., & Salmeron-Sanchez, P. (2013). Sexual compulsivity scale: Adaptation and validation in the Spanish population. Journal of Sex and Marital Therapy, 39, 526–540.
Berlan, E. D., Corliss, H. L., Field, A. E., Goodman, E., & Austin, S. B. (2010). Sexual orientation and bullying among adolescents in the Growing Up Today Study. Journal of Adolescent Health, 46, 366–371.
Beyrer, C., Baral, S. D., van Griensven, F., Goodreau, S. M., Chariyalertsak, S., Wirtz, A. L., & Brookmeyer, R. (2012). Global epidemiology of HIV infection in men who have sex with men. Lancet, 380, 367–377.
Biello, K., Colby, C., Closson, E., & Mimiaga, M. J. (2014a). The syndemic condition of psychosocial problems and HIV risk among male sex workers in Ho Chi Minh City, Vietnam. AIDS and Behavior, 18, 1267–1271.
Biello, K., Rosenberger, J., Novak, D., Robertson, A., Mayer, K., & Mimiaga, M. (2014b). Epidemiology of sexual health in the virtual environment: A multinational online survey of Spanish- and Portuguese-speaking men who use an internet sexual networking site. AIDS and Behavior, 18, 1675–1685.
Blashill, A. J., Perry, N., & Safren, S. A. (2011). Mental health: A focus on stress, coping, and mental illness as it relates to treatment retention, adherence, and other health outcomes. Current HIV/AIDS Reports, 8, 215–222.
Brennan, J., Kuhns, L. M., Johnson, A. K., Belzer, M., Wilson, E. C., Garofalo, R., & Adolescent Medicine Trials Network for HIV/AIDS Interventions. (2012). Syndemic theory and HIV-related risk among young transgender women: The role of multiple, co-occurring health problems and social marginalization. American Journal of Public Health, 102, 1751–1757.
Chesney, M. A., Koblin, B. A., Barresi, P. J., Husnik, M. J., Celum, C. L., Colfax, G., et al. (2003). An individually tailored intervention for HIV prevention: Baseline data from the EXPLORE Study. American Journal of Public Health, 93, 933–938.
Chiasson, M. A., Parsons, J. T., Tesoriero, J. M., Carballo-Dieguez, A., Hirshfield, S., & Remien, R. H. (2006). HIV behavioral research online. Journal of Urban Health, 8, 73–85.
Cochran, S. D., Ackerman, D., Mays, V. M., & Ross, M. W. (2004). Prevalence of non-medical drug use and dependence among homosexually active men and women in the US population. Addiction, 99, 989–998.
Cochran, S. D., & Mays, V. M. (2000). Lifetime prevalence of suicide symptoms and affective disorders among men reporting same-sex sexual partners: Results from NHANES III. American Journal of Public Health, 90, 573–578.
Cochran, S. D., Mays, V. M., & Sullivan, J. G. (2003). Prevalence of mental disorders, psychological distress, and mental health services use among lesbian, gay, and bisexual adults in the United States. Journal of Consulting and Clinical Psychology, 71, 53–61.
Curioso, W. H., Blas, M. M., Nodell, B., Alva, I. E., & Kurth, A. E. (2007). Opportunities for providing web-based interventions to prevent sexually transmitted infections in Peru. PLoS Medicine, 4, e11.
De Boni, R., Veloso, V. G., & Grinsztein, B. (2014). Epidemiology of HIV in Latin America and the Caribbean. Current Opinion in HIV and AIDS, 9, 192–198.
De Cock, K. M., Jaffe, H. W., & Curran, J. W. (2012). The evolving epidemiology of HIV/AIDS. AIDS, 26, 1205–1213.
Dyer, T. P., Shoptaw, S., Guadamuz, T. E., Plankey, M., Kao, U., Ostrow, D., et al. (2012). Application of syndemic theory to black men who have sex with men in the Multicenter AIDS Cohort Study. Journal of Urban Health, 89, 697–708.
Ewing, J. A. (1984). Detecting alcoholism: The CAGE questionnaire. Journal of the American Medical Association, 252, 1905–1907.
Farmer, P. (1999). Infections and inequality: The modern plagues. Berkeley, CA: University of California Press.
Ferlatte, O., Hottes, T. S., Trussler, T., & Marchand, R. (2014). Evidence of a syndemic among young Canadian gay and bisexual men: Uncovering the associations between anti-gay experiences, psychosocial issues, and HIV risk. AIDS and Behavior, 18, 1256–1263.
Fiellin, D. A., Reid, M. C., & O’Connor, P. G. (2000). Screening for alcohol problems in primary care: A systematic review. Archives of Internal Medicine, 160, 1977–1989.
Fitzmaurice, G. M., Laird, N. M., & Ware, J. H. (2004). Applied longitudinal analysis. Hoboken, NJ: Wiley.
Geibel, S., Tun, W., Tapsoba, P., & Kellerman, S. (2010). HIV vulnerability of men who have sex with men in developing countries: Horizons studies, 2001-2008. Public Health Reports, 125, 316–324.
Gilman, S. E., Cochran, S. D., Mays, V. M., Hughes, M., Ostrow, D., & Kessler, R. C. (2001). Risk of psychiatric disorders among individuals reporting same-sex sexual partners in the National Comorbidity Survey. American Journal of Public Health, 91, 933–939.
Gonzalez, J. S., Batchelder, A. W., Psaros, C., & Safren, S. A. (2011). Depression and HIV/AIDS treatment nonadherence: A review and meta-analysis. Journal of Acquired Immune Deficiency Syndrome, 58, 181–187.
Grant R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A.Y., Vargas, L., et al. (2010). Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New England Journal of Medicine, 363, 2587–2599.
Greenwood, G. L., Relf, M. V., Huang, B., Pollack, L. M., Canchola, J. A., & Cantania, J. A. (2002). Battering victimization among a probability-based sample of men who have sex with men. American Journal of Public Health, 92, 1964–1969.
Haberer, J. E., Baeten, J. M., Campbell, J., Wangisi, J., Katabira, E., Ronald, A., et al. (2013). Adherence to antiretroviral prophylaxis for HIV prevention: A substudy cohort within a clinical trial of serodiscordant couples in East Africa. PLOS Medicine, 10, e1001511. doi:10.1371/journal.pmed.1001511.
Halkitis, P. N., Wolitski, R. J., & Millett, G. A. (2013). A holistic approach to addressing HIV infection disparities in gay, bisexual, and other men who have sex with men. American Psychologist, 68, 261–273.
Herrick, A. L., Lim, S. H., Plankey, M. W., Chmiel, J. S., Guadamuz, T. E., Kao, U., et al. (2013). Adversity and syndemic production among men participating in the Multicenter AIDS Cohort Study: A life-course approach. American Journal of Public Health, 103, 79–85.
Hirshfield, S., Remien, R. H., Humberstone, M., Walavalkar, I., & Chiasson, M. A. (2004). Substance use and high-risk sex among men who have sex with men: A national online study in the USA. AIDS Care, 16, 1036–1047.
Jie, W., Ciyong, L., Xueqing, D., Hui, W., & Lingyao, H. (2012). A syndemic of psychosocial problems places the MSM (men who have sex with men) population at greater risk of HIV infection. PLoS ONE, 7, e32312.
Kalichman, S. C., & Rompa, D. (1995). Sexual sensation seeking and sexual compulsivity scales: Validity, and predicting HIV risk behavior. Journal of Personality Assessment, 65, 586–601.
King, M., Semlyen, J., Tai, S. S., Killaspy, H., Osborn, D., Popelyuk, D., & Nazarethm, I. (2008). A systematic review of mental disorder, suicide, and deliberate self harm in lesbian, gay and bisexual people. BMC Psychiatry, 8, 70.
Koblin, B. A., Chesney, M. A., & Coates, T. (2004). Effects of a behavioural intervention to reduce acquisition of HIV infection among men who have sex with men: The EXPLORE randomized controlled study. Lancet, 364, 41–50.
Koblin, B. A., Chesney, M. A., Husnik, M. J., Bozeman, S., Celum, C. L., Buchbinder, S., et al. (2003). High-risk behaviors among men who have sex with men in six US cities: Baseline data from the EXPLORE Study. American Journal of Public Health, 93, 926–932.
Liau, A., Millett, G., & Marks, G. (2006). Meta-analytic examination of online sex-seeking and sexual risk behavior among men who have sex with men. Sexually Transmitted Diseases, 33, 576–584.
Marcus, U., Hickson, F., Weatherburn, P., & Schmidt, A. J. (2012). Prevalence of HIV among MSM in Europe: Comparison of self-reported diagnoses from a large scale internet survey and existing national estimates. BMC Public Health, 12, 978.
Marcus, U., Schmidt, A. J., Hamouda, O., & Bochow, M. (2009). Estimating the regional distribution of men who have sex with men (MSM) based on Internet surveys. BMC Public Health, 9, 180.
Marshal, M. P., Friedman, M. S., Stall, R., King, K. M., Miles, J., Gold, M. A., et al. (2008). Sexual orientation and adolescent substance use: A meta-analysis and methodological review. Addiction, 103, 546–556.
Meyer, I. H. (2003). Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence. Psychological Bulletin, 129, 674–697.
Mimiaga, M. J., Noonan, E., Donnell, D., Safren, S. A., Koenan, K. C., Gortmaker, S., et al. (2009). Childhood sexual abuse is highly associated with HIV risk-taking behavior and infection among MSM in the EXPLORE Study. Journal of Acquired Immune Deficiency Syndrome, 51, 340–348.
Mimiaga, M. J., O’Cleirigh, C., Biello, K.B., Robertson, A.M., Safren, S. A., Coates, T. J., et al. (2015). The effect of psychosocial syndemic production on 4-year HIV incidence and risk behavior in a large cohort of sexually active men who have sex with men. Journal of Acquired Immune Deficiency Syndrome, 68, 329–336.
Mustanski, B., Garofalo, R., Herrick, A., & Donenberg, G. (2007). Psychosocial health problems increase risk for HIV among urban young men who have sex with men: Preliminary evidence of a syndemic in need of attention. Annals of Behavioral Medicine, 34, 37–45.
Parsons, J. T., Grov, C., & Golub, S. A. (2012). Sexual compulsivity, co-occurring psychosocial health problems, and HIV risk among gay and bisexual men: Further evidence of a syndemic. American Journal of Public Health, 102, 156–162.
Reisner, S. L., Mimiaga, M. J., Skeer, M., Bright, D., Cranston, K., Isenberg, D., et al. (2009). Clinically significant depressive symptoms as a risk factor for HIV infection among black MSM in Massachusetts. AIDS and Behavior, 13, 798–810.
Rogers, G., Curry, M., Oddy, J., Pratt, N., Beilby, J., & Wilkinson, D. (2003). Depressive disorders and unprotected casual anal sex among Australian homosexually active men in primary care. HIV Medicine, 4, 271–275.
Rosenberger, J. G., Reece, M., Schick, V., Herbenick, D., Novak, D. S., Van Der Pol, B., & Fortenberry, J. D. (2011). Sexual behaviors and situational characteristics of most recent male-partnered sexual event among gay and bisexually identified men in the United States. Journal of Sexual Medicine, 8, 3040–3050.
Ruiz-Grosso, P., Loret de Mola, C., Vega-Dienstmaier, J. M., Arevalo, J. M., Chavez, K., Vilela, A., & Huapaya, J. (2012). Validation of the Spanish Center for Epidemiological Studies Depression and Zung Self-Rating Depression Scales: A comparative validation study. PLoS One, 7(10), e45413.
Safren, S. A., Blashill, A. J., & O’Cleirigh, C. M. (2011). Promoting the sexual health of MSM in the context of comorbid mental health problems. AIDS and Behavior, 15, S30–S34.
Safren, S. A., & Heimberg, R. G. (1999). Depression, hopelessness, suicidality, and related factors in sexual minority and heterosexual adolescents. Journal of Consulting and Clinical Psychology, 67, 859–866.
Safren, S. A., Reisner, S. L., Herrick, A., Mimiaga, M. J., & Stall, R. D. (2010). Mental health and HIV risk in men who have sex with men. Journal of Acquired Immune Deficiency Syndrome, 55(Suppl. 2), S74–S77.
Saitz, R., Lepore, M. F., Sullivan, L. M., Amaro, H., & Samet, J. H. (1999). Alcohol abuse and dependence in Latinos living in the United States: Validation of the CAGE (4M) questions. Archives of Internal Medicine, 159, 718–724.
Santos, G. M., Do, T., Beck, J., Makofane, K., Arreola, S., Pyun, T., et al. (2014). Syndemic conditions associated with increased HIV risk in a global sample of men who have sex with men. Sexually Transmitted Infections, 90, 250–253.
Singer, M. (1994). AIDS and the health crisis of the U.S. urban poor: The perspective of critical medical anthropology. Social Science and Medicine, 39, 931–948.
Singer, M., & Clair, S. (2003). Syndemics and public health: Reconceptualizing disease in bio-social context. Medical Anthropology Quarterly, 17, 423–441.
Singer, M. C., Erickson, P. I., Badiane, L., Diaz, R., Ortiz, D., Abraham, T., & Nicolaysen, A. M. (2006). Syndemics, sex and the city: Understanding sexually transmitted diseases in social and cultural context. Social Science and Medicine, 63, 2010–2021.
Stall, R., Friedman, M., & Catania, J. (2008). Interacting epidemics and gay men’s health: A theory of syndemic production among urban gay men. In R. J. Wolitski, R. Stall, & R. O. Valdiserri (Eds.), Unequal opportunity: Health disparities affecting gay and bisexual men in the United States (pp. 251–274). New York, NY: Oxford University Press.
Stall, R., Mills, T. C., Williamson, J., Hart, T., Greenwood, G., Paul, J., et al. (2003). Association of co-occurring psychosocial health problems and increased vulnerability to HIV/AIDS among urban men who have sex with men. American Journal of Public Health, 93, 939–942.
Stall, R., Paul, J. P., Greenwood, G., Pollack, L. M., Bein, E., Crosby, G. M., et al. (2001). Alcohol use, drug use and alcohol-related problems among men who have sex with men: The Urban Men’s Health Study. Addiction, 96, 1589–1601.
Stupiansky, N. W., Rosenberger, J. G., Schick, V., Herbenick, D., Novak, D. S., & Reece, M. (2010). Factors associated with sexually transmitted infection testing among men who utilize an internet-based men who have sex with men community. AIDS Patient Care and STDS, 24, 713–717.
Sullivan, P. S., Hamouda, O., Delpech, V., Geduld, J. E., Prejean, J., Semaille, C., et al. (2009). Reemergence of the HIV epidemic among men who have sex with men in North America, Western Europe, and Australia, 1996-2005. Annals of Epidemiology, 19, 423–431.
Sullivan, P. S., Khosropour, C. M., Luisi, N., Amsden, M., Coggia, T., Wingood, G. M., & DiClemente, R. J. (2011). Bias in online recruitment and retention of racial and ethnic minority men who have sex with men. Journal of Medical Internet Research, 13, e38.
Swendeman, D., & Rotheram-Borus, M. J. (2010). Innovation in sexually transmitted disease and HIV prevention: Internet and mobile phone delivery vehicles for global diffusion. Current Opinion in Psychiatry, 23, 139–144.
Wang, L., Wang, L., Norris, J. L., Li, D. M., Guo, W., Ding, Z. W., & Wang, N. (2012). HIV prevalence and influencing factors analysis of sentinel surveillance among men who have sex with men in China, 2003–2011. Chinese Medical Journal, 125, 1857–1861.
Wim, V. B., Christiana, N., & Marie, L. (2014). Syndemic and other risk factors for unprotected anal intercourse among an online sample of Belgian HIV negative men who have sex with men. AIDS and Behavior, 18, 50–58.
Yu, F., Nehl, E. J., Zheng, T., He, N., Berg, C. J., Lemieux, A. F., et al. (2013). A syndemic including cigarette smoking and sexual risk behaviors among a sample of MSM in Shanghai, China. Drug and Alcohol Dependence, 132, 265–270.
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Mimiaga, M.J., Biello, K.B., Robertson, A.M. et al. High Prevalence of Multiple Syndemic Conditions Associated with Sexual Risk Behavior and HIV Infection Among a Large Sample of Spanish- and Portuguese-Speaking Men Who Have Sex with Men in Latin America. Arch Sex Behav 44, 1869–1878 (2015). https://doi.org/10.1007/s10508-015-0488-2
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DOI: https://doi.org/10.1007/s10508-015-0488-2