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Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

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Abstract

The goal of this work is to better understand utilization and uptake of pre-exposure prophylaxis (PrEP) among young men who have sex with men (YMSM) and transgender women (TGW). We assessed trends and correlates of PrEP use and adherence across three time points of longitudinal data collection among 885 YMSM and TGW (aged 16–29) from the RADAR cohort in Chicago, 2015–2017. Past 6-month PrEP use increased across three visits: from 6.6 to 17.5%. In multivariable models, past 6-month PrEP use was significantly associated with participation in condomless sex, having more sexual partners, and older age. At least three-quarters of current PrEP users reported being ≥ 90% adherent to PrEP medication across all visits. Past 6-month PrEP use increased over time with those who participated in high-risk HIV behaviors also those most likely to have taken PrEP. As PrEP uptake continues to rise, more research will be needed to understand predictors of PrEP usage, as well as patterns of sexual behavior change following uptake.

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Acknowledgements

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health. The sponsor had no involvement in the conduct of the research or the preparation of the article. The authors would like to thank the entire RADAR research team, particularly Dr. Thomas Remble and Antonia Clifford for overseeing the project and Daniel T. Ryan for data management. We also thank the RADAR participants for sharing their experiences with us.

Funding

This study was funded by a Grant from the National Institute on Drug Abuse at the National Institutes of Health (U01DA036939; PI: Mustanski).

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Authors and Affiliations

  1. Department of Medical Social Sciences, Northwestern University, Chicago, IL, USA

    Ethan Morgan, Kevin Moran, Daniel T. Ryan, Brian Mustanski & Michael E. Newcomb

  2. Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, 625 N Michigan Ave Suite 14-044, Chicago, IL, 60611, USA

    Ethan Morgan, Kevin Moran, Daniel T. Ryan, Brian Mustanski & Michael E. Newcomb

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  1. Ethan Morgan
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  2. Kevin Moran
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  5. Michael E. Newcomb
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Correspondence to Ethan Morgan.

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The authors have no conflicts of interest to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study and this study was approved by the Northwestern University Institutional Review Board.

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Morgan, E., Moran, K., Ryan, D.T. et al. Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago. AIDS Behav 22, 3637–3644 (2018). https://doi.org/10.1007/s10461-018-2122-5

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