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Alcohol Interactive Toxicity Beliefs and ART Non-adherence Among HIV-Infected Current Drinkers in Mbarara, Uganda

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Abstract

Interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapy (ART) may influence ART adherence. HIV-infected patients in Uganda completed quarterly visits for 1 year, or one visit at 6 months, depending on study randomization. Past month ART non-adherence was less than daily or <100 % on a visual analog scale. Participants were asked if people who take alcohol should stop taking their medications (belief) and whether they occasionally stopped taking their medications in anticipation of drinking (behavior). Visits with self-reported alcohol use and ART use for ≥30 days were included. We used logistic regression to examine correlates of the interactive toxicity belief and behavior, and to determine associations with ART non-adherence. 134 participants contributed 258 study visits. The toxicity belief was endorsed at 24 %, the behavior at 15 %, and any non-adherence at 35 % of visits. In multivariable analysis, the odds of non-adherence were higher for those endorsing the toxicity behavior [adjusted odds ratio (AOR) 2.06; 95 % confidence interval (CI) 0.97–4.36] but not the toxicity belief (AOR 0.63; 95 % CI 0.32–1.26). Clear messaging about maintaining adherence, even if drinking, could benefit patients.

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Acknowledgments

We would like to thank the BREATH Study participants for their time and participation, and the BREATH Study team members for their hard work and dedication.

Funding

This work was funded by the US National Institutes of Health, Grants R01AA018631, U01AA020776, and K24AA022586.

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Authors and Affiliations

  1. Department of Medicine, University of California San Francisco, Box 1224, 550 16th Street, San Francisco, CA, 94158, USA

    Robin Fatch, Nneka I. Emenyonu, Sarah Woolf-King & Judith A. Hahn

  2. Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda

    Winnie Muyindike & Allen Kekibiina

  3. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA

    Judith A. Hahn

Authors
  1. Robin Fatch
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  2. Nneka I. Emenyonu
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  3. Winnie Muyindike
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  5. Sarah Woolf-King
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  6. Judith A. Hahn
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Correspondence to Robin Fatch.

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Ethical Approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Fatch, R., Emenyonu, N.I., Muyindike, W. et al. Alcohol Interactive Toxicity Beliefs and ART Non-adherence Among HIV-Infected Current Drinkers in Mbarara, Uganda. AIDS Behav 21, 1812–1824 (2017). https://doi.org/10.1007/s10461-016-1429-3

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