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Outcomes of Antiretroviral Therapy in the Swiss HIV Cohort Study: Latent Class Analysis

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Abstract

An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions.

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Acknowledgments

This study was funded in the framework of the Swiss HIV Cohort Study and a PROSPER fellowhip to O Keiser, both supported by the Swiss National Science Foundation. The members of the Swiss HIV Cohort Study are Barth J, Battegay M, Bernasconi E, Böni J, Bucher HC, Bürgisser P, Burton-Jeangros C, Calmy A, Cavassini M, Dubs R, Egger M, Elzi L, Fehr J, Fischer M, Flepp M, Francioli P (President of the SHCS), Furrer H (Chairman of the Clinical and Laboratory Committee), Fux CA, Gorgievski M, Günthard H (Chairman of the Scientific Board), Hasse B, Hirsch HH, Hirschel B, Hösli I, Kahlert C, Kaiser L, Keiser O, Kind C, Klimkait T, Kovari H, Ledergerber B, Martinetti G, Martinez de Tejada B, Müller N, Nadal D, Pantaleo G, Rauch A, Regenass S, Rickenbach M (Head of Data Center), Rudin C (Chairman of the Mother & Child Substudy), Schmid P,Schultze D, Schöni-Affolter F, Schüpbach J, Speck R, Taffé P, Telenti A, Trkola A, Vernazza P, von Wyl V, Weber R, Yerly S.

Author information

Authors and Affiliations

  1. Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland

    Olivia Keiser, Ben Spycher & Matthias Egger

  2. University Clinic for Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland

    Andri Rauch

  3. Division of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland

    Alexandra Calmy

  4. Division of Infectious Diseases, University Hospital Lausanne, Lausanne, Switzerland

    Matthias Cavassini

  5. Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland

    Tracy R. Glass

  6. Division of Infectious Diseases, Cantonal Hospital St.Gallen, St.Gallen, Switzerland

    Dunja Nicca

  7. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Zürich, Zürich, Switzerland

    Bruno Ledergerber

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  1. Olivia Keiser
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  2. Ben Spycher
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  3. Andri Rauch
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  4. Alexandra Calmy
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  5. Matthias Cavassini
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  6. Tracy R. Glass
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  7. Dunja Nicca
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  8. Bruno Ledergerber
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  9. Matthias Egger
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The Swiss HIV Cohort Study

Corresponding author

Correspondence to Olivia Keiser.

Additional information

Olivia Keiser and Ben Spycher contributed equally to this study.

The members of The Swiss HIV Cohort Study are given in the acknowledgement.

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Keiser, O., Spycher, B., Rauch, A. et al. Outcomes of Antiretroviral Therapy in the Swiss HIV Cohort Study: Latent Class Analysis. AIDS Behav 16, 245–255 (2012). https://doi.org/10.1007/s10461-011-9971-5

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  • DOI: https://doi.org/10.1007/s10461-011-9971-5

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