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Aging, Prospective Memory, and Health-Related Quality of Life in HIV Infection

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Abstract

HIV infection and older age are each independently associated with lower health-related quality of life (HRQoL) and deficits in prospective memory (PM), which is a distinct aspect of cognition involving the ability to “remember to remember” to do something at a future occasion. The present study investigated associations between PM and HRQoL in 72 older (≥50 years) and 41 younger (≤40 years) HIV-infected adults. Self-reported PM complaints predicted HRQoL across the entire sample, but there was a significant interaction between performance-based PM and age group on HRQoL, such that lower time-based PM was associated with lower HRQoL only in the younger cohort. Within the younger group, time-based and self-reported PM significantly predicted mental HRQoL independent of other risk factors (e.g. depression). These findings suggest that PM plays a unique role in HRQoL outcomes among younger persons living with HIV infection and support the examination of other age-related factors (e.g. effective use of compensatory strategies) that may regulate the adverse impact of PM on everyday functioning.

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Acknowledgments

The San Diego HIV Neurobehavioral Research Program (HNRP) group is affiliated with the University of California, San Diego, the Naval Hospital, San Diego, and the Veterans Affairs San Diego Healthcare System, and includes: Director: Igor Grant M.D. ; Co-Directors: J. Hampton Atkinson M.D., Ronald J. Ellis M.D., Ph.D., and J. Allen McCutchan M.D.; Center Manager: Thomas D. Marcotte Ph.D.; Jennifer Marquie-Beck M.P.H.; Melanie Sherman; Neuromedical Component: Ronald J. Ellis M.D., Ph.D. (P.I.), J. Allen McCutchan M.D., Scott Letendre M.D., Edmund Capparelli Pharm. D., Rachel Schrier Ph.D., Terry Alexander R. N., Debra Rosario M.P.H., Shannon LeBlanc; Neurobehavioral Component: Robert K. Heaton Ph.D. (P.I.), Steven Paul Woods Psy.D., Mariana Cherner Ph.D., David J. Moore Ph.D., Matthew Dawson; Neuroimaging Component: Terry Jernigan Ph.D. (P.I.), Christine Fennema-Notestine Ph.D., Sarah L. Archibald M.A., John Hesselink M.D., Jacopo Annese Ph.D., Michael J. Taylor Ph.D.; Neurobiology Component: Eliezer Masliah M.D. (P.I.), Cristian Achim M.D., Ph.D., Ian Everall, FRCPsych., FRCPath., Ph.D. (Consultant); Neurovirology Component: Douglas Richman M.D., (P.I.), David M. Smith M.D.; International Component: J. Allen McCutchan M.D., (P.I.); Developmental Component: Cristian Achim M.D., Ph.D.; (P.I.), Stuart Lipton M.D., Ph.D.; Participant Accrual and Retention Unit: J. Hampton Atkinson M.D. (P.I.), Rodney von Jaeger M.P.H.; Data Management Unit: Anthony C. Gamst Ph.D. (P.I.), Clint Cushman (Data Systems Manager); Statistics Unit: Ian Abramson Ph.D. (P.I.), Florin Vaida Ph.D., Reena Deutsch Ph.D., Anya Umlauf M.S., Tanya Wolfson M.A. This research was supported by National Institutes of Health grants R01-MH073419, T32-DA31098, and P30-MH62512. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government. Aspects of these data were presented at the 40th Annual Meeting of the International Neuropsychological Society in Montreal, QC. The authors thank Marizela Cameron, Nichole Duarte, and P. Katie Riggs for their help with study management and Dr. Sarah Raskin for providing us with the MIST.

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, San Diego, CA, 92093, USA

    Katie Doyle, J. Hampton Atkinson, Igor Grant & Steven Paul Woods

  2. Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, San Diego, CA, 92183, USA

    Erica Weber

  3. Department of Psychiatry, UCSD, 220 Dickinson Street, Suite B, San Diego, CA, 92103-8231, USA

    Steven Paul Woods

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The HIV Neurobehavioral Research Program (HNRP) Group

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Correspondence to Katie Doyle or Steven Paul Woods.

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Doyle, K., Weber, E., Atkinson, J.H. et al. Aging, Prospective Memory, and Health-Related Quality of Life in HIV Infection. AIDS Behav 16, 2309–2318 (2012). https://doi.org/10.1007/s10461-011-0121-x

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