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Mental Health Treatment to Reduce HIV Transmission Risk Behavior: A Positive Prevention Model

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Abstract

Secondary HIV prevention, or “positive prevention,” is concerned with reducing HIV transmission risk behavior and optimizing the health and quality of life of people living with HIV/AIDS (PLWHA). The association between mental health and HIV transmission risk (i.e., sexual risk and poor medication adherence) is well established, although most of this evidence is observational. Further, a number of efficacious mental health treatments are available for PLWHA yet few positive prevention interventions integrate mental health treatment. We propose that mental health treatment, including behavioral and pharmacologic interventions, can lead to reductions in HIV transmission risk behavior and should be a core component of secondary HIV prevention. We present a conceptual model and recommendations to guide future research on the effect of mental health treatment on HIV transmission risk behavior among PLWHA.

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References

  1. UNAIDS. Report on the global AIDS epidemic. Geneva: UNAIDS; 2008.

    Google Scholar 

  2. Hall HI, Song R, Rhodes P, et al. Estimation of HIV incidence in the United States. JAMA. 2008;300(5):520–9.

    CAS  PubMed  Google Scholar 

  3. Lima VD, Harrigan R, Bangsberg DR, et al. The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time. J Acquir Immune Defic Syndr. 2009;50(5):529–36.

    CAS  PubMed  Google Scholar 

  4. Baker JV, Peng G, Rapkin J, et al. CD4 + count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS. 2008;22(7):841–8.

    PubMed  Google Scholar 

  5. Crepaz N, Marks G, Liau A, et al. Prevalence of unprotected anal intercourse among HIV-diagnosed MSM in the United States: a meta-analysis. AIDS. 2009;23(13):1617–29.

    PubMed  Google Scholar 

  6. Weinhardt L, Kelly JA, Brondino M, et al. HIV transmission risk behavior among men and women living with HIV in 4 cities in the United States. J Acquir Immune Defic Syndr. 2004;36(5):1057–66.

    PubMed  Google Scholar 

  7. Bing EG, Burnam MA, Longshore D, et al. Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiatry. 2001;58(8):721–8.

    CAS  PubMed  Google Scholar 

  8. Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Defic Syndr. 2005;39(4):446–53.

    PubMed  Google Scholar 

  9. Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296(6):679–90.

    CAS  PubMed  Google Scholar 

  10. Boily MC, Baggaley RF, Wang L, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis. 2009;9(2):118–29.

    PubMed  Google Scholar 

  11. Xiridou M, Geskus R, de Wit J, Coutinho R, Kretzschmar M. Primary HIV infection as source of HIV transmission within steady and casual partnerships among homosexual men. AIDS. 2004;18(9):1311–20.

    PubMed  Google Scholar 

  12. Flaks RC, Burman WJ, Gourley PJ, Rietmeijer CA, Cohn DL. HIV transmission risk behavior and its relation to antiretroviral treatment adherence. Sex Transm Dis. 2003;30(5):399–404.

    PubMed  Google Scholar 

  13. Chakraborty H, Sen PK, Helms RW, et al. Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. AIDS. 2001;15(5):621–7.

    CAS  PubMed  Google Scholar 

  14. Porco TC, Martin JN, Page-Shafer KA, et al. Decline in HIV infectivity following the introduction of highly active antiretroviral therapy. AIDS. 2004;18(1):81–8.

    PubMed  Google Scholar 

  15. Mugavero MJ, Lin HY, Allison JJ, et al. Racial disparities in HIV virologic failure: do missed visits matter? J Acquir Immune Defic Syndr. 2009;50(1):100–8.

    PubMed  Google Scholar 

  16. Lima VD, Harrigan R, Murray M, et al. Differential impact of adherence on long-term treatment response among naive HIV-infected individuals. AIDS. 2008;22(17):2371–80.

    PubMed  Google Scholar 

  17. Baum MK, Rafie C, Lai S, Sales S, Page B, Campa A. Crack-cocaine use accelerates HIV disease progression in a cohort of HIV-positive drug users. J Acquir Immune Defic Syndr. 2009;50(1):93–9.

    PubMed  Google Scholar 

  18. Mugavero MJ, Lin HY, Willig JH, et al. Missed visits and mortality among patients establishing initial outpatient HIV treatment. Clin Infect Dis. 2009;48(2):248–56.

    PubMed  Google Scholar 

  19. Mullins CD, Whitelaw G, Cooke JL, Beck EJ. Indirect cost of HIV infection in England. Clin Ther. 2000;22(11):1333–45.

    CAS  PubMed  Google Scholar 

  20. Gardner EM, Maravi ME, Rietmeijer C, Davidson AJ, Burman WJ. The association of adherence to antiretroviral therapy with healthcare utilization and costs for medical care. Appl Health Econ Health Policy. 2008;6(2–3):145–55.

    PubMed  Google Scholar 

  21. Chesney MA, Ickovics JR, Chambers DB, et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. AIDS Care. 2000;12(3):255–66.

    CAS  PubMed  Google Scholar 

  22. Kleeberger CA, Phair JP, Strathdee SA, Detels R, Kingsley L, Jacobson LP. Determinants of heterogenous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr. 2001;26(1):82–92.

    CAS  PubMed  Google Scholar 

  23. Crepaz N, Lyles CM, Wolitski RJ, et al. Do prevention interventions reduce HIV risk behaviours among people living with HIV? A meta-analytic review of controlled trials. AIDS. 2006;20(2):143–57.

    PubMed  Google Scholar 

  24. Johnson BT, Carey MP, Chaudoir SR, Reid AE. Sexual risk reduction for persons living with HIV: research synthesis of randomized controlled trials, 1993 to 2004. J Acquir Immune Defic Syndr. 2006;41(5):642–50.

    PubMed  Google Scholar 

  25. Fisher JD, Smith L. Secondary prevention of HIV infection: the current state of prevention for positives. Curr Opin HIV AIDS. 2009;4(4):279–87.

    PubMed  Google Scholar 

  26. Grossman CI, Gordon CM. Mental health considerations in secondary HIV prevention. AIDS Behav. [Published online 5 Dec 2008].

  27. Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001;158(5):725–30.

    CAS  PubMed  Google Scholar 

  28. Lyketsos CG, Hutton H, Fishman M, Schwartz J, Treisman GJ. Psychiatric morbidity on entry to an HIV primary care clinic. AIDS. 1996;10(9):1033–9.

    CAS  PubMed  Google Scholar 

  29. Olley BO, Seedat S, Stein DJ. Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: a 6-month follow-up study. J Psychosom Res. 2006;61(4):479–84.

    PubMed  Google Scholar 

  30. Pence BW, Miller WC, Gaynes BN, Eron JJ Jr. Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2007;44(2):159–66.

    PubMed  Google Scholar 

  31. Atkinson JH Jr, Grant I, Kennedy CJ, Richman DD, Spector SA, McCutchan JA. Prevalence of psychiatric disorders among men infected with human immunodeficiency virus. A controlled study. Arch Gen Psychiatry. 1988;45(9):859–64.

    PubMed  Google Scholar 

  32. Israelski DM, Prentiss DE, Lubega S, et al. Psychiatric co-morbidity in vulnerable populations receiving primary care for HIV/AIDS. AIDS Care. 2007;19(2):220–5.

    CAS  PubMed  Google Scholar 

  33. Safren SA, Gershuny BS, Hendriksen E. Symptoms of posttraumatic stress and death anxiety in persons with HIV and medication adherence difficulties. AIDS Patient Care STDS. 2003;17(12):657–64.

    PubMed  Google Scholar 

  34. Atkinson JH, Higgins JA, Vigil O, et al. Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IV. AIDS Behav. 2009;13:1061–67.

    PubMed  Google Scholar 

  35. Humfleet GL, Delucchi K, Kelley K, Hall SM, Dilley J, Harrison G. Characteristics of HIV-positive cigarette smokers: a sample of smokers facing multiple challenges. AIDS Educ Prev. 2009;21(3 Suppl):54–64.

    PubMed  Google Scholar 

  36. Martinez A, Israelski D, Walker C, Koopman C. Posttraumatic stress disorder in women attending human immunodeficiency virus outpatient clinics. AIDS Patient Care STDS. 2002;16(6):283–91.

    PubMed  Google Scholar 

  37. Cohen MA, Batista SM, Gorman JM. Anxiety disorders. In: Cohen MA, Gorman JM, editors. Comprehensive textbook of AIDS psychiatry. New York: Oxford University Press; 2008. p. 121–30.

    Google Scholar 

  38. Kelly B, Raphael B, Judd F, et al. Posttraumatic stress disorder in response to HIV infection. Gen Hosp Psychiatry. 1998;20(6):345–52.

    CAS  PubMed  Google Scholar 

  39. Kalichman SC. Co-occurrence of treatment nonadherence and continued HIV transmission risk behaviors: implications for positive prevention interventions. Psychosom Med. 2008;70(5):593–7.

    PubMed  Google Scholar 

  40. Bradley MV, Remien RH, Dolezal C. Depression symptoms and sexual HIV risk behavior among serodiscordant couples. Psychosom Med. 2008;70(2):186–91.

    PubMed  Google Scholar 

  41. Ryan K, Forehand R, Solomon S, Miller C. Depressive symptoms as a link between barriers to care and sexual risk behavior of HIV-infected individuals living in non-urban areas. AIDS Care. 2008;20(3):331–6.

    CAS  PubMed  Google Scholar 

  42. Bousman CA, Cherner M, Ake C, et al. Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV. J Affect Disord. 2009;119(1–3):84–91.

    CAS  PubMed  Google Scholar 

  43. Valverde EE, Cassetti I, Metsch LR, et al. Sex risk practices among HIV-positive individuals in Buenos Aires, Argentina. AIDS Patient Care STDS. 2009;23(7):551–6.

    PubMed  Google Scholar 

  44. Mugavero M, Ostermann J, Whetten K, et al. Barriers to antiretroviral adherence: the importance of depression, abuse, and other traumatic events. AIDS Patient Care STDS. 2006;20(6):418–28.

    PubMed  Google Scholar 

  45. Gordillo V, del Amo J, Soriano V, Gonzalez-Lahoz J. Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS. 1999;13(13):1763–9.

    CAS  PubMed  Google Scholar 

  46. Mellins CA, Kang E, Leu CS, Havens JF, Chesney MA. Longitudinal study of mental health and psychosocial predictors of medical treatment adherence in mothers living with HIV disease. AIDS Patient Care STDS. 2003;17(8):407–16.

    PubMed  Google Scholar 

  47. Rajabiun S, Mallinson RK, McCoy K, et al. “Getting me back on track”: the role of outreach interventions in engaging and retaining people living with HIV/AIDS in medical care. AIDS Patient Care STDS. 2007;21(Suppl 1):S20–9.

    PubMed  Google Scholar 

  48. Hutton HE, Lyketsos CG, Zenilman JM, Thompson RE, Erbelding EJ. Depression and HIV risk behaviors among patients in a sexually transmitted disease clinic. Am J Psychiatry. 2004;161(5):912–4.

    PubMed  Google Scholar 

  49. Reisner SL, Mimiaga MJ, Skeer M, Mayer KH. Beyond anal sex: sexual practices associated with HIV risk reduction among men who have sex with men in Boston, Massachusetts. AIDS Patient Care STDS. 2009;23(7):545–50.

    PubMed  Google Scholar 

  50. Klein H, Elifson KW, Sterk CE. Depression and HIV risk behavior practices among at risk women. Womens Health. 2008;48(2):167–88.

    Google Scholar 

  51. Hart TA, James CA, Purcell DW, Farber E. Social anxiety and HIV transmission risk among HIV-seropositive male patients. AIDS Patient Care STDS. 2008;22(11):879–86.

    PubMed  Google Scholar 

  52. Reyes JC, Robles RR, Colon HM, et al. Severe anxiety symptomatology and HIV risk behavior among Hispanic injection drug users in Puerto Rico. AIDS Behav. 2007;11(1):145–50.

    PubMed  Google Scholar 

  53. Hutton HE, Treisman GJ, Hunt WR, et al. HIV risk behaviors and their relationship to posttraumatic stress disorder among women prisoners. Psychiatr Serv. 2001;52(4):508–13.

    CAS  PubMed  Google Scholar 

  54. Reisner SL, Mimiaga MJ, Safren S, Mayer K. Stressful or traumatic life events, post-traumatic stress disorder (PTSD) symptoms, and HIV sexual risk taking among men who have sex with men. AIDS Care. 2009;21(12):1481–9.

    PubMed  Google Scholar 

  55. Crepaz N, Marks G. Are negative affective states associated with HIV sexual risk behaviors? A meta-analytic review. Health Psychol. 2001;20(4):291–9.

    CAS  PubMed  Google Scholar 

  56. Crepaz N, Marks G. Towards an understanding of sexual risk behavior in people living with HIV: a review of social, psychological, and medical findings. AIDS. 2002;16(2):135–49.

    PubMed  Google Scholar 

  57. Kalichman SC, Weinhardt L. Negative affect and sexual risk behavior: comment on Crepaz and Marks (2001). Health Psychol. 2001;20(4):300–1.

    CAS  PubMed  Google Scholar 

  58. Chesney MA, Koblin BA, Barresi PJ, et al. An individually tailored intervention for HIV prevention: baseline data from the EXPLORE study. Am J Public Health. 2003;93(6):933–8.

    PubMed  Google Scholar 

  59. Rogers G, Curry M, Oddy J, Pratt N, Beilby J, Wilkinson D. Depressive disorders and unprotected casual anal sex among Australian homosexually active men in primary care. HIV Med. 2003;4(3):271–5.

    CAS  PubMed  Google Scholar 

  60. Reisner SL, Mimiaga MJ, Skeer M, et al. Clinically significant depressive symptoms as a risk factor for HIV infection among black MSM in Massachusetts. AIDS Behav. 2009;13(4):798–810.

    PubMed  Google Scholar 

  61. Meade CS, Hansen NB, Kochman A, Sikkema KJ. Utilization of medical treatments and adherence to antiretroviral therapy among hiv-positive adults with histories of childhood sexual abuse. AIDS Patient Care STDS. 2009;23(4):259–66.

    PubMed  Google Scholar 

  62. Vranceanu AM, Safren SA, Lu M, et al. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in persons with HIV. AIDS Patient Care STDS. 2008;22(4):313–21.

    PubMed  Google Scholar 

  63. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000;160(14):2101–7.

    CAS  PubMed  Google Scholar 

  64. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.

    Google Scholar 

  65. Ammassari A, Trotta MP, Murri R, et al. Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature. J Acquir Immune Defic Syndr. 2002;31(Suppl 3):S123–7.

    PubMed  Google Scholar 

  66. Vervoort SC, Borleffs JC, Hoepelman AI, Grypdonck MH. Adherence in antiretroviral therapy: a review of qualitative studies. AIDS. 2007;21(3):271–81.

    PubMed  Google Scholar 

  67. Mocroft A, Madge S, Johnson AM, et al. A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival. J Acquir Immune Defic Syndr. 1999;22(4):369–78.

    CAS  PubMed  Google Scholar 

  68. Fairfield KM, Libman H, Davis RB, Eisenberg DM. Delays in protease inhibitor use in clinical practice. J Gen Intern Med. 1999;14(7):395–401.

    CAS  PubMed  Google Scholar 

  69. Gebo KA, Fleishman JA, Conviser R, et al. Racial and gender disparities in receipt of highly active antiretroviral therapy persist in a multistate sample of HIV patients in 2001. J Acquir Immune Defic Syndr. 2005;38(1):96–103.

    PubMed  Google Scholar 

  70. Turner BJ, Fleishman JA, Wenger N, et al. Effects of drug abuse and mental disorders on use and type of antiretroviral therapy in HIV-infected persons. J Gen Intern Med. 2001;16(9):625–33.

    CAS  PubMed  Google Scholar 

  71. Scott-Sheldon LA, Kalichman SC, Carey MP, Fielder RL. Stress management interventions for HIV+ adults: a meta-analysis of randomized controlled trials, 1989 to 2006. Health Psychol. 2008;27(2):129–39.

    PubMed  Google Scholar 

  72. Himelhoch S, Medoff DR, Oyeniyi G. Efficacy of group psychotherapy to reduce depressive symptoms among HIV-infected individuals: a systematic review and meta-analysis. AIDS Patient Care STDS. 2007;21(10):732–9.

    PubMed  Google Scholar 

  73. Crepaz N, Passin WF, Herbst JH, et al. Meta-analysis of cognitive-behavioral interventions on HIV-positive persons’ mental health and immune functioning. Health Psychol. 2008;27(1):4–14.

    PubMed  Google Scholar 

  74. Himelhoch S, Medoff DR. Efficacy of antidepressant medication among HIV-positive individuals with depression: a systematic review and meta-analysis. AIDS Patient Care STDS. 2005;19(12):813–22.

    PubMed  Google Scholar 

  75. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: Erlbaum; 1988.

    Google Scholar 

  76. Cuijpers P, Van Straten A, Warmerdam L, Smits N. Characteristics of effective psychological treatments of depression: a metaregression analysis. Psychother Res. 2008;18(2):225–36.

    PubMed  Google Scholar 

  77. Robinson LA, Berman JS, Neimeyer RA. Psychotherapy for the treatment of depression: a comprehensive review of controlled outcome research. Psychol Bull. 1990;108(1):30–49.

    CAS  PubMed  Google Scholar 

  78. Katzman MA, Tricco AC, McIntosh D, et al. Paroxetine versus placebo and other agents for depressive disorders: a systematic review and meta-analysis. J Clin Psychiatry. 2007;68(12):1845–59.

    CAS  PubMed  Google Scholar 

  79. Moncrieff J, Wessely S, Hardy R. Active placebos versus antidepressants for depression. Cochrane Database Syst Rev. 2004;1:CD003012.

    PubMed  Google Scholar 

  80. Cuijpers P, van Straten A, Andersson G, van Oppen P. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consult Clin Psychol. 2008;76(6):909–22.

    PubMed  Google Scholar 

  81. Hunot V, Churchill R, Silva de Lima M, Teixeira V. Psychological therapies for generalised anxiety disorder. Cochrane Database Syst Rev. 2007;1:CD001848.

    PubMed  Google Scholar 

  82. Sikkema KJ, Wilson PA, Hansen NB, et al. Effects of a coping intervention on transmission risk behavior among people living with HIV/AIDS and a history of childhood sexual abuse. J Acquir Immune Defic Syndr. 2008;47(4):506–13.

    PubMed  Google Scholar 

  83. Coates TJ, McKusick L, Kuno R, Stites DP. Stress reduction training changed number of sexual partners but not immune function in men with HIV. Am J Public Health. 1989;79(7):885–7.

    CAS  PubMed  Google Scholar 

  84. Williams JK, Wyatt GE, Rivkin I, Ramamurthi HC, Li X, Liu H. Risk reduction for HIV-positive African American and Latino men with histories of childhood sexual abuse. Arch Sex Behav. 2008;37(5):763–72.

    PubMed  Google Scholar 

  85. Kelly JA, Murphy DA, Bahr GR, et al. Outcome of cognitive-behavioral and support group brief therapies for depressed, HIV-infected persons. Am J Psychiatry. 1993;150(11):1679–86.

    CAS  PubMed  Google Scholar 

  86. Healthy Living Project Team. Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: the healthy living project randomized controlled study. J Acquir Immune Defic Syndr. 2007;44(2):213–21.

    Google Scholar 

  87. Wyatt GE, Longshore D, Chin D, et al. The efficacy of an integrated risk reduction intervention for HIV-positive women with child sexual abuse histories. AIDS Behav. 2004;8(4):453–62.

    PubMed  Google Scholar 

  88. Safren SA, O’Cleirigh C, Tan JY, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol. 2009;28(1):1–10.

    PubMed  Google Scholar 

  89. Johnson MO, Charlebois E, Morin SF, Remien RH, Chesney MA. Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: the healthy living project randomized controlled study. J Acquir Immune Defic Syndr. 2007;46(5):574–80.

    PubMed  Google Scholar 

  90. Antoni MH, Baggett L, Ironson G, et al. Cognitive-behavioral stress management intervention buffers distress responses and immunologic changes following notification of HIV-1 seropositivity. J Consult Clin Psychol. 1991;59(6):906–15.

    CAS  PubMed  Google Scholar 

  91. Goodkin K, Fuchs I, Feaster DJ, Leeka J, Rishel DD. Life stressors and coping style are associated with immune measures in HIV-1 infection—a preliminary report. Int J Psychiatry Med. 1992;22:155–72.

    CAS  PubMed  Google Scholar 

  92. McCain NL, Zeller JM, Cella DF, Urbanski PA, Novak RM. The influence of stress management training in HIV disease. Nurs Res. 1996;45:246–53.

    CAS  PubMed  Google Scholar 

  93. Sikkema KJ, Hansen NB, Tarakeshwar N, Kochman A, Tate DC, Lee RS. The clinical significance of change in trauma-related symptoms following a pilot group intervention for coping with HIV-AIDS and childhood sexual trauma. AIDS Behav. 2004;8(3):277–91.

    PubMed  Google Scholar 

  94. Greenberg J. Childhood sexual abuse and sexually transmitted diseases in adults: a review of and implications for STD/HIV programmes. Int J STD AIDS. 2001;12(12):777–83.

    CAS  PubMed  Google Scholar 

  95. Senn TE, Carey MP, Vanable PA. Childhood and adolescent sexual abuse and subsequent sexual risk behavior: evidence from controlled studies, methodological critique, and suggestions for research. Clin Psychol Rev. 2008;28(5):711–35.

    PubMed  Google Scholar 

  96. Kalichman SC, Sikkema KJ, DiFonzo K, Luke W, Austin J. Emotional adjustment in survivors of sexual assault living with HIV/AIDS. J Trauma Stress. 2002;15(4):189–296.

    Google Scholar 

  97. O’Leary A, Purcell D, Remien RH, Gomez C. Childhood sexual abuse and sexual transmission risk behaviour among HIV-positive men who have sex with men. AIDS Care. 2003;15(1):17–26.

    PubMed  Google Scholar 

  98. Mimiaga MJ, Noonan E, Donnell D, et al. Childhood sexual abuse is highly associated with HIV risk-taking behavior and infection among MSM in the EXPLORE study. J Acquir Immune Defic Syndr. 2009;51(3):340–8.

    PubMed  Google Scholar 

  99. Lazarus R, Folkman S. Stress, appraisal and coping. New York: Springer; 1984.

    Google Scholar 

  100. Folkman S, Chesney M, McKusick L, Ironson G, Johnson D, Coates T. Translating coping theory into an intervention. In: Eckenrode J, editor. The social context of coping. New York: Plenum Press; 1991. p. 239–60.

    Google Scholar 

  101. Sikkema KJ, Hansen NB, Kochman A, et al. Outcomes from a group intervention for coping with HIV/AIDS and childhood sexual abuse: reductions in traumatic stress. AIDS Behav. 2007;11:49–60.

    PubMed  Google Scholar 

  102. Meade C, Drabkin AS, Wilson PA, Hansen NB, Kochman A, Sikkema K. Reductions in alcohol and cocaine use following a group coping intervention for HIV positive adults with childhood sexual abuse histories. Boston: CFAR Social and Behavioral Sciences Research Network Meeting; 2009.

    Google Scholar 

  103. Carrico AW, Chesney MA, Johnson MO, et al. Randomized controlled trial of a cognitive-behavioral intervention for HIV-positive persons: an investigation of treatment effects on psychosocial adjustment. AIDS Behav. 2009;13(3):555–63.

    PubMed  Google Scholar 

  104. Wong FL, Rotheram-Borus MJ, Lightfoot M, et al. Effects of behavioral intervention on substance use among people living with HIV: the healthy living project randomized controlled study. Addiction. 2008;103(7):1206–14.

    PubMed  Google Scholar 

  105. Kumar V, Encinosa W. Effects of antidepressant treatment on antiretroviral regimen adherence among depressed HIV-infected patients. Psychiatr Q. 2009;80:131–41.

    PubMed  Google Scholar 

  106. Tsai A, Weiser S, Petersen M, Raglans K, Bangsberg D. Effect of antidepressant medication treatment on antiretroviral adherence and HIV-1 RNA viral load in HIV+ homeless and marginally housed individuals. In: 16th Conference on retroviruses and opportunistic infections. Montreal; 2009.

  107. Yun LW, Maravi M, Kobayashi JS, Barton PL, Davidson AJ. Antidepressant treatment improves adherence to antiretroviral therapy among depressed HIV-infected patients. J Acquir Immune Defic Syndr. 2005;38(4):432–8.

    CAS  PubMed  Google Scholar 

  108. Walkup J, Wei W, Sambamoorthi U, Crystal S. Antidepressant treatment and adherence to combination antiretroviral therapy among patients with AIDS and diagnosed depression. Psychiatr Q. 2008;79(1):43–53.

    PubMed  Google Scholar 

  109. Horberg MA, Silverberg MJ, Hurley LB, et al. Effects of depression and selective serotonin reuptake inhibitor use on adherence to highly active antiretroviral therapy and on clinical outcomes in HIV-infected patients. J Acquir Immune Defic Syndr. 2008;47(3):384–90.

    CAS  PubMed  Google Scholar 

  110. Gaynes BN, Pence BW, Eron JJ Jr, Miller WC. Prevalence and comorbidity of psychiatric diagnoses based on reference standard in an HIV+ patient population. Psychosom Med. 2008;70(4):505–11.

    PubMed  Google Scholar 

  111. World Health Organization. The World Health Report 2001: mental health—new understanding, new hope. Geneva: World Health Organization; 2001.

    Google Scholar 

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Acknowledgments

This research was partially supported by the Duke University Center for AIDS Research (P30-AI064518) and grant R01-MH078731.

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Sikkema, K.J., Watt, M.H., Drabkin, A.S. et al. Mental Health Treatment to Reduce HIV Transmission Risk Behavior: A Positive Prevention Model. AIDS Behav 14, 252–262 (2010). https://doi.org/10.1007/s10461-009-9650-y

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