Abstract
Retaining high-risk individuals is critical for HIV prevention trials. The current analyses examined predictors of trial dropout among HIV-infected men and women in a multi-site HIV prevention trial. Results indicated that dropouts (n = 74) were more likely to be younger, depressed, and not taking antiretroviral therapy (ART) than those who continued (n = 815). No other background, substance use, or transmission risk differences were found, suggesting no direct evidence of dropout bias on key outcomes. Efforts may be warranted for early detection and treatment of depression and for improving retention of younger participants and those not on ART.
References
Beck, A. T., Steer, R. A., & Garbin, M. G. (1988). Psychometric properties of the Beck depression inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8, 77–100.
Brown-Peterside, P., Rivera, E., Lucy, D., Slaughter, I., Ren, L., Chiasson, M. A., et al. (2001). Retaining hard-to-reach women in HIV prevention and vaccine trials: Project ACHIEVE. American Journal of Public Health, 9, 1377–1379.
Davis, L., Evans, S., Fishman, B., Haley, A., & Spielman, L. A. (2004). Predictors of attrition in HIV-positive subjects with peripheral neuropathic pain. AIDS Care, 16, 395–402.
DiFranceisco, W., Kelly, J. A., Sikkema, K. J., Somlai, A. M., Murphy, D. A., & Stevenson, L. Y. (1998). Differences between completers and early dropouts from 2 HIV intervention trials: A health belief approach to understanding prevention program attrition. American Journal of Public Health, 88, 1068–1073.
Healthy Living Project Team (2007). Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: The healthy living project randomized controlled study. Journal of Acquired Immune Deficiency Syndromes, 44, 213–221.
Husband, S. D., Marlowe, D. B., Lamb, R. J., Iguchi, M. Y., Bux, D. A., Kirby, K. C., et al. (1996). Decline in self-reported dysphoria after treatment entry in inner-city cocaine addicts. Journal of Consulting and Clinical Psychology, 64, 221–224.
Lima, V. D., Geller, J., Bangsberg, D. R., Patterson, T. L., Daniel, M., Kerr, T., et al. (2007). The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART. AIDS, 21, 1175–1183.
Mykletun, A., Bjerkeset, O., Dewey, M., Prince, M., Overland, S., & Stewart, R. (2007). Anxiety, depression, and cause-specific mortality: The HUNT study. Psychosomatic Medicine, 69, 323–331.
Roffman, R. A., Klepsch, R., Wertz, J. S., Simpson, E. E., & Stephens, R. S. (1993). Predictors of attrition from an outpatient marijuana-dependence counseling program. Addictive Behaviors, 18, 553–566.
Roffman, R. A., Picciano, J. F., Bolan, M., & Kalichman, S. C. (1997). Factors associated with attrition from an HIV-prevention program for gay and bisexual males. AIDS and Behavior, 1(2), 125–135.
Vanable, P. A., Carey, M. P., Carey, K. B., & Maisto, S. A. (2002). Predictors of participation and attrition in a health promotion study involving psychiatric outpatients. Journal of Consulting and Clinical Psychology, 70, 362–368.
Yohannes, A. M., Yalfani, A., Doherty, P., & Bundy, C. (2007). Predictors of drop-out from an outpatient cardiac rehabilitation programme. Clinical Rehabilitation, 21, 222–229.
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Johnson, M.O., Dilworth, S.E., Neilands, T.B. et al. Predictors of Attrition Among High Risk HIV-Infected Participants Enrolled in a Multi-Site Prevention Trial. AIDS Behav 12, 974–977 (2008). https://doi.org/10.1007/s10461-007-9356-y
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DOI: https://doi.org/10.1007/s10461-007-9356-y