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Morphological and molecular aspects of physiological vascular morphogenesis

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Abstract

The cardiovascular system plays a crucial role in vertebrate development and homeostasis. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. During embryonal life, blood vessels first appear as the result of vasculogenesis, whereas remodeling of the primary vascular plexus occurs by angiogenesis. Many tissue-derived factors are involved in blood vessel formation and evidence is emerging that endothelial cells themselves represent a source of instructive signals to non-vascular tissue cells during organ development. This review article summarizes our knowledge concerning the principal factors involved in the regulation of vascular morphogenesis.

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Acknowledgments

Supported in part by MIUR (PRIN 2007), Rome, and Fondazione Cassa di Risparmio di Puglia, Bari, Italy.

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  1. Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico, 70124, Bari, Italy

    Domenico Ribatti & Beatrice Nico

  2. Department of Medical and Morphological Research, Anatomy Section, University of Udine Medical School, Udine, Italy

    Enrico Crivellato

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Correspondence to Domenico Ribatti.

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Ribatti, D., Nico, B. & Crivellato, E. Morphological and molecular aspects of physiological vascular morphogenesis. Angiogenesis 12, 101–111 (2009). https://doi.org/10.1007/s10456-008-9125-1

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