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Diagnostic value of history taking in reflex syncope

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Abstract.

The medical history, in combination with the physical examination and a 12-lead electrocardiogram, plays a key role in the diagnosis and risk stratification of patients with syncope. However, diagnostic clinical criteria are not uniformly applied. In older studies, the diagnostic criteria for vasovagal or reflex syncope often included typical precipitating events and warning symptoms. More recent studies have documented that a variety of unrecognized stressors can trigger reflex syncope and that warning signs and symptoms may be minimal. A characteristic medical history (a trigger and/or prodromi) is enough to diagnose reflex syncope if the risk for a cardiac cause of syncope is low (e. g. patients < 65 yrs, without a history of heart disease and no ECG abnormalities). In elderly subjects with a higher risk of cardiac syncope, the yield of the medical history is lower. However, a prospective study of the value of the medical history for the diagnosis of syncope with long-term follow-up has not been performed.

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References

  1. Alboni P, Brignole M, Menozzi C, Raviele A, Del Rosso A, Dinelli M, Sol ano A, Bottoni N (2001) Diagnostic Value of History in Patients With Syncope With or Without Heart Disease. J Am Coll Cardiol 37:1921–1928

    Article  CAS  PubMed  Google Scholar 

  2. Ammirati F, Colivicchi F, Santini M (2000) Diagnosing syncope in clinical practice. Implementation of a simplified diagnostic algorithm in a multicentre prospective trial; the OESIL 2 Study (Osservatorio Epidemiologico della Sincope nel Lazio). Eur Heart J 21:935–940

    Article  CAS  PubMed  Google Scholar 

  3. Benbadis SR, Wolgamuth BR, Goren H, Brener S, Fouad-Tarazi F (1995) Value of tongue biting in the diagnosis of seizures. Arch Intern Med 155:2346–2349

    Article  PubMed  Google Scholar 

  4. Benditt DG (1997) Clinical neuromythology. XV. Feinting science. Neurology 49:901–902

    CAS  PubMed  Google Scholar 

  5. Benke Th, Hochleitner M, Bauer G (1997) Aura Phenomena during Syncope. Eur Neurol 37:28–32

    PubMed  Google Scholar 

  6. Bergen D, Ristanovic R (1993) Weeping as a common element of pseudoseizures. Arch Neurol 50:1059–1060

    CAS  PubMed  Google Scholar 

  7. Blanc J-J, L’her C, Touiza A, Garo B, L’her E, Mansourati J (2002) Prospective evaluation and outcome of patients admitted for syncope over a 1 year period. Eur Heart J 23:815–820

    Article  PubMed  Google Scholar 

  8. Brignole M, Alboni P, Benditt DG, Bergfeldt l, Blanc JJ, Bloch Thomsen PE,Dijk JGv, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor WN, Kenny RA, Kulakowski P, Moya A, Raviele A, Sutton R, Theodorakis G, Wieling W (2001) Guidelines on management (diagnosis and treatment) of syncope. Eur Heart J 22:1256–1306

    Article  PubMed  Google Scholar 

  9. Calkins H, Kadish A, Sousa J, Rosenheck S, Morady F (1991) Comparison of responses to isoproterenol and epinephrine during head-up tilt in suspected vasodepressor syncope. Am J Cardiol 67:207–209

    Article  CAS  PubMed  Google Scholar 

  10. Calkins H, Shyr Y, Frumin H, Schork A, Morady F (1995) The value of the clinical history in the differentiation of syncope due to ventricular tachycardia, atrioventricular block, and neurocardiogenic syncope. Am J Med 98:365–373

    Article  CAS  PubMed  Google Scholar 

  11. Colivicchi F, Ammirati F, Melina D, Guido V, Imperoli G, Santini M (2003) Development and prospective validation of a risk stratification system for patients with syncope in the emergency department: the OESIL risk score. Eur Heart J 24:811–819

    Article  PubMed  Google Scholar 

  12. DeToledo JC, Ramsay RE (1996) Patterns of involvement of facial muscles during epileptic and nonepileptic events: review of 654 events. Neurology 47:621–625

    CAS  PubMed  Google Scholar 

  13. Dijk JGv (2003) Conditions which mimic syncope. In: Benditt DG, Blanc JJ, Brignole M, Sutton R (eds) The evaluation and treatment of syncope: a handbook for clinical practice. Blackwell/Futura, pp 184–200

  14. Eagle KA, Black HR, Martin et al. (1983) Evaluation of patients with syncope. New England Journal of Medicine, Vol 309(26):1650–1652)

    PubMed  Google Scholar 

  15. Farwell D, Sulke N (2002) How do we diagnose syncope? J Cardiovasc Electrophysiol 13:S9–13

    PubMed  Google Scholar 

  16. Fletcher RH, Fletcher SW, Wagner EH (1982) Clinical Epidemiology. The Essentials. Williams and Wilkins, Baltimore

  17. Friis ML, Lund M (1974) Stress convulsions. Arch Neurol 31:155–159

    CAS  PubMed  Google Scholar 

  18. Ganzeboom KS, Colman N, Reitsma JB, Shen WK, Wieling W (2003) Prevalence and triggers of syncope in medical students. Am J Cardiol 91:1006–1008

    Article  PubMed  Google Scholar 

  19. Gastaut H (1974) Syncopes: generalized anoxic cerebral seizures. In: Magnus O, Haas AM (eds) Handbook of clinical neurology. Amsterdam, pp 815–836

  20. Gastaut H, Fischer-Williams M (1957) Electro-encephalographic study of syncope: its difference from epilepsy. Lancet 2:1018–1025

    Article  Google Scholar 

  21. Graham LA, Kenny RA (2002) Clinical characteristics of unexplained syncope and their relationship to tilt table test outcomes. Clin Auton Res 12:88–93

    Article  PubMed  Google Scholar 

  22. Hoefnagels WA, Padberg GW, Overweg J, van der Velde EA, Roos RA (1991) Transient loss of consciousness: the value of the history for distinguishing seizure from syncope. J Neurol 238:39–43

    CAS  PubMed  Google Scholar 

  23. Johnson RH, Lambie DG, Spalding JMK (1984) Syncope without heart disease. In: Johnson RH, Lambie DG, Spalding JMK (eds) Neurocardiology. The interrelationships between dysfunction in the nervous and cardiovascular system. WB Saunders, London, pp 159–183

  24. Kapoor WN (1990) Evaluation and outcome of patients with syncope. Medicine (Baltimore) 69:160–175

    CAS  PubMed  Google Scholar 

  25. Kapoor WN (1999) Using a tilt table to evaluate syncope. Am J Med Sci 317:110–116

    Article  CAS  PubMed  Google Scholar 

  26. Kassirer JP, Kopelman RI (1991) Cases that teach clinical reasoning. Hosp Pract (Off Ed) 26:29–36

    Google Scholar 

  27. Kosinski D, Grubb BP (1997) Clinical neuromythology. XV. Feinting science. Neurology 49:902

    CAS  PubMed  Google Scholar 

  28. Krediet CTP, van Dijk N, Linzer M, van Lieshout JJ, Wieling W (2002) Management of Vasovagal Syncope: Controlling or Aborting Faints by Leg Crossing and Muscle Tensing. Circulation 106:1684–1689

    Article  PubMed  Google Scholar 

  29. Landau WM, Nelson DA (1996) Clinical neuromythology XV. Feinting science: Neurocardiogenic syncope and collateral vasovagal confusion. Neurology 46:609–618

    CAS  PubMed  Google Scholar 

  30. Landau WM, Nelson DA (1997) Clinical neuromythology XV. Feinting science: Reply from the Authors. Neurology 49:902–904

    CAS  PubMed  Google Scholar 

  31. Lempert T, Bauer M, Schmidt D (1994) Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann Neurol 36:233–237

    CAS  PubMed  Google Scholar 

  32. Lieshout JJv, Wieling W, Karemaker JM, Eckberg DL (1991) The vasovagal response. [Review] [167 refs]. Clin Sci (Colch) 81:575–586

    PubMed  Google Scholar 

  33. Linzer M, Pontinen M, Gold DT, Divine GW, Felder A, Brooks WB (1991) Impairment of physical and psychosocial function in recurrent syncope. J Clin Epidemiol 44:1037–1043

    Article  CAS  PubMed  Google Scholar 

  34. Linzer M, Yang EH, Estes MI, Wang P, Vorperian VR, Kapoor WN (1997) Diagnosing Syncope Part 1:Value of History, Physical Examination, and Electrocardiography. Ann Intern Med 126:989–996

    CAS  PubMed  Google Scholar 

  35. Luciano D, Devinsky O, Perrine K (1993) Crying seizures. Neurology 43:2113–2117

    CAS  PubMed  Google Scholar 

  36. Martin GJ, Adams SL, Martin HG, Mathews J, Zull D, Scanlon PJ (1984) Prospective evaluation of syncope. Ann Emerg Med 13:499–504

    CAS  PubMed  Google Scholar 

  37. Martin TP, Hanusa BH, Kapoor WN (1997) Risk Stratification of Patients With Syncope. Annals of Emergency Medicine 29(4):459–466

    CAS  PubMed  Google Scholar 

  38. McGinn TG, Guyatt GH, Wyer PC, Naylor CD, Stiell IG, Richardson WS, for the Evidence-Based Medicine Working Group (2000) Users’ Guides to the Medical Literature: XXII: How to Use Articles About Clinical Decision Rules. JAMA: J Am Med Assoc 284:79–84

    Article  CAS  Google Scholar 

  39. Moya A, Brignole M, Menozzi C, Garcia-Civera R, Tognarini S, Mont L, Botto G, Giada F, Cornacchia D (2001) Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncope. Circulation 104:1261–1267

    CAS  PubMed  Google Scholar 

  40. Newman BH, Graves S (2001) A study of 178 consecutive vasovagal syncopal reactions from the perspective of safety. Transfusion 41:1475–1479

    Article  CAS  PubMed  Google Scholar 

  41. Oh JH, Hanusa BH, Kapoor WN (1999) Do symptoms predict cardiac arrhythmias and mortality in patients with syncope? [see comments]. Arch Intern Med 159:375–380

    Article  CAS  PubMed  Google Scholar 

  42. Oribe E, Caro S, Perera R, Winters SL Gomes JA, Kaufmann H (1997) Syncope: the diagnostic value of head-up tilt testing. Pacing Clin Electrophysiol 20:874–879

    CAS  PubMed  Google Scholar 

  43. Petch MC (1994) Syncope [editorial] [see comments]. BMJ 308:1251–1252

    CAS  PubMed  Google Scholar 

  44. Rowell LB (1993) Human cardiovascular control. Oxford Unversity Press, Oxford, pp 118–161

  45. Sandercock P (2002) A fainting mechanic. Lancet 360:305

    Article  PubMed  Google Scholar 

  46. Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Rajeswaran A, Metzger JT, Lovis C,Unger PF, Junod AF (2001) Prospective Evaluation of Patients with Syncope: A Population-based Study. Am J Med 111:177–184

    Article  CAS  PubMed  Google Scholar 

  47. Sharpey-Schafer EP (1956) Emergencies in general practice. Syncope. Br Med J 506–509

  48. Sheldon R (2003) Role of defined questionnaire for diagnosis of syncope and other forms of transient loss of consciousness. In: Benditt DG, Blanc JJ, Brignole M, Sutton R (eds) The evaluation and treatment of syncope: a handbook for clinical practice. Blackwell/Futura, pp 46–50

  49. Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, Frenneaux M, Fisher M, Murphy W (2002) Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol 40:142–148

    Article  PubMed  Google Scholar 

  50. Blackwell Scientific Publications Ltd, Oxford

  51. Stephenson JBP, McLeod KA (2000) Reflex Anoxic Seizures. In: David TJ (ed) Recent Advances in Pediatrics 18. Churchill Livingstone, Edinburgh, pp 1–17

  52. Sutton R, Nathan A, Perrins J, Skehan D, Davies W, Kenny RA (1994) Syncope. A good history is not enough [letter, comment]. BMJ 309:474

    CAS  Google Scholar 

  53. Sutton R, Petersen ME (1995) The clinical spectrum of neurocardiogenic syncope. J Cardiovasc Electrophysiol 6:569–576

    CAS  PubMed  Google Scholar 

  54. Waxman MB, Yao L, Cameron DA, Wald RW, Roseman J (1989) Isoproterenol induction of vasodepressortype reaction in vasodepressor-prone persons. Am J Cardiol 63:58–65

    Article  CAS  PubMed  Google Scholar 

  55. Wayne HH (1961) Syncope: Physiological considerations and an analysis of the clinical characteristics in 510 patients. Am J Med 30:418–438

    Article  CAS  PubMed  Google Scholar 

  56. Wieling W, Ganzeboom KS, Crediet CTP, Grundmeijer HGLM, Wilde AAM, Dijk JGv (2003) Initial diagnostic strategy in the case of transient losses of consciousness: the importance of the medical history. Ned Tijdschr Geneeskd 147:849–854

    Google Scholar 

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Colman, N., Nahm, K., van Dijk, J.G. et al. Diagnostic value of history taking in reflex syncope. Clin Auton Res 14 (Suppl 1), i37–i44 (2004). https://doi.org/10.1007/s10286-004-1006-0

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