Abstract
This study evaluated the role of the phototherapy and exercise training (EXT) as well as the combined treatment in general symptoms, pain, and quality of life in women suffering from fibromyalgia (FM). A total of 160 women were enrolled and measures were carried out in two sets: it was sought to identify the acute effect for a single phototherapy and EXT session (Set 1); long-term effect (10 weeks) of the interventions (Set 2). Phototherapy irradiation was performed at 11 locations in their bodies, employing a cluster with nine diodes (one super-pulsed infrared 905 nm, four light-emitting diodes [LEDs] of 640 nm, and four LEDs of 875 nm, 39.3 J per location). Algometry and VAS instrument were applied to evaluate pain. The FM symptoms were evaluated with Fibromyalgia Impact Questionnaire (FIQ) and Research Diagnostic Criteria (RDC) instruments. Quality of life was assessed through SF-36 survey. Set 1: pain threshold was improved with the phototherapy, and EXT improved the pain threshold for temporomandibular joint (right and left body side) and occipital site (right body side). Set 2: there was improved pain threshold in several tender points with the phototherapy and EXT. There was an overlap of therapies to reduce the tender point numbers, anxiety, depression, fatigue, sleep, and difficulty sleeping on FIQ/RDC scores. Moreover, quality of life was improved with both therapies. The phototherapy and EXT improved the pain threshold in FM women. A more substantial effect was noticed for the combined therapy, in which pain relief was accomplished by improving VAS and FIQ scores as well as quality of life.
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References
Hazemeijer I, Rasker JJ (2003) Fibromyalgia and the therapeutic domain: a philosophical study on the origins of fibromyalgia in a specific social setting. Rheumatology (Oxford) 42:507–515
Wolfe F, Clauw DJ, Fitzcharles MA et al (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 62:600–610
Cassisi G, Ceccherelli F, Atzeni F, Sarzi-Puttini P (2013) Complementary and alternative medicine in fibromyalgia: a practical clinical debate of agreements and contrasts. Clin Exp Rheumatol 31:S134–S152
Busch AJ, Barber KA, Overend TJ, Peloso PM, Schachter CL (2007) Exercise for treating fibromyalgia syndrome. Cochrane Database Syst Rev 4:CD003786
Orlandi AC, Ventura C, Gallinaro AL, Costa RA, Lage LV (2012) Improvement in pain, fatigue, and subjective sleep quality through sleep hygiene tips in patients with fibromyalgia. Rev Bras Reumatol 52:672–678
da Silva MM, Albertini R, Leal-Junior EC et al (2015) Effects of exercise training and photobiomodulation therapy (EXTRAPHOTO) on pain in women with fibromyalgia and temporomandibular disorder: study protocol for a randomized controlled trial. Trials 16:252
Ruaro JA, Fréz AR, Ruaro MB, Nicolau RA (2014) Low level laser therapy to treat fibromyalgia. Lasers Med Sci 29:1815–1819
Alves AMB, Natour J, Assis MR, Feldman D (2012) Assessment of different instruments used as outcome measures in patients with fibromyalgia. Rev Bras Reumatol 52:501–506
Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 35:773–782
Serra AJ, Silva JA Jr, Marcolongo AA et al (2013) Experience in resistance training does not prevent reduction in muscle strength evoked by passive static stretching. J Strength Cond Res 27:2304–2308
Bidonde J, Busch AJ, Schachter CL et al (2017) Aerobic exercise training for adults with fibromyalgia. Cochrane Database Syst Rev 6:CD012700
Zijlstra TR, Taal E, van de Laar MA, Rasker JJ (2007) Validation of a Dutch translation of the fibromyalgia impact questionnaire. Rheumatology (Oxford) 46:131–134
Kosek E, Ekholm J, Hansson P (1996) Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. Pain 64:415–423
Lautenbacher S, Rollman GB, McCain GA (1994) Multi-method assessment of experimental and clinical pain in patients with fibromyalgia. Pain 59:45–53
Naugle KM, Fillingim RB, Riley JL 3rd (2012) A meta-analytic review of the hypoalgesic effects of exercise. J Pain 13:1139–1150
Vierck CJ Jr, Staud R, Price DD, Cannon RL, Mauderli AP, Martin AD (2001) The effect of maximal exercise on temporal summation of second pain (windup) in patients with fibromyalgia syndrome. J Pain 2:334–344
Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH (2017) Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev 1:CD011279
Leal-Junior EC, Johnson DS, Saltmarche A, Demchak T (2014) Adjunctive use of combination of super-pulsed laser and light-emitting diodesphototherapy on nonspecific knee pain: double-blinded randomized placebo-controlled trial. Lasers Med Sci 29:1839–1847
Herpich CM, Leal-Junior ECP, Gomes CAFP (2017) Immediate and short-term effects of phototherapy on pain, muscle activity, and joint mobility in women with temporomandibular disorder: a randomized, double-blind, placebo-controlled, clinical trial. Disabil Rehabil 11:1–7
Bjordal JM (2012) Low level laser therapy (LLLT) and World Association for Laser Therapy (WALT) dosage recommendations. Photomed Laser Surg 30:61–62
Ash C, Dubec M, Donne K, Bashford T (2017) Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods. Lasers Med Sci [Epub ahead of print]
Jones MD, Booth J, Taylor JL, Barry BK (2014) Aerobic training increases pain tolerance in healthy individuals. Med Sci Sports Exerc 46:1640–1647
Kingsley JD, Demchak T, Mathis R (2014) Low-level laser therapy as a treatment for chronic pain. Front Physiol 5:306
Cidral-Filho FJ, Mazzardo-Martins L, Martins D, Santos ARS (2014) Light-emitting diode therapy induces analgesia in a mouse model of post operative pain through activation of peripheral opioid receptors and the L-arginine/nitric oxide pathway. Lasers Med Sci 29:695–702
Gür A, Karakoc M, Nas K, Cevik R, Sarac J, Ataoglu S (2002) Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial. Rheumatol Int 22:188–193
Eccles NJ (2005) A critical review of randomized controlled trials of static magnets for pain relief. J Altern Compliment Med 11:495–509
Kontantinovic L, Antoic M, Mihuajlovic M, Vucetic D (1989) Use of low dose lasers in physiatry. Vojnosanit Pregl 46:441–448
Vayvay ES, Tok D, Turgut E, Tunay VB (2016) The effect of laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: a placebo- randomized controlled clinical trial. J Back Musculoskelet Rehabil 29:77–83
Acknowledgements
The study was funded by a grant from the FAPESP (Award Number 15/11028-9) and CNPq (305139/2013-4). The funders had no role in the study design; collection, analysis, and interpretation of data; writing the report; and the decision to submit the report for publication. We thank Pontual Translation for critical reviewing of English language.
Role of funding source
This study was supported by National Council for Scientific and Technological Development (grant number: 305139/2013-4) and São Paulo Research Foundation (grant number: 15/11028-9). The funds have no influence on data collection and analysis of results as well as structuring the manuscript.
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Ernesto Cesar Pinto Leal Junior receives research support from Multi Radiance Medical (Solon, OH, USA), a laser device manufacturer. The remaining authors declare that they have no competing interests.
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The ethical committee of Universidade Nove de Julho approved the study protocol (number: 419.828/2013).
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da Silva, M.M., Albertini, R., de Tarso Camillo de Carvalho, P. et al. Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers Med Sci 33, 343–351 (2018). https://doi.org/10.1007/s10103-017-2388-2
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DOI: https://doi.org/10.1007/s10103-017-2388-2