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Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study

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Abstract

Vestibular migraine (VM) is one of the most frequent causes of episodic vertigo, with a lifetime prevalence of 0.98 %. Prophylactic therapy includes calcium channel blockers, beta-blockers, antiepileptic drugs and antidepressants. We studied the association of cinnarizine 20 mg and dimenhydrinate 40 mg (Arlevertan©) in a group of 22 patients affected by definite VM. Proposed therapy included one tablet twice a day for 1 month, which was repeated three times with 1 month of interval between drug intake; results were compared with those of a control group of 11 VM patients who asked to observe only lifestyle measures for migraine. The main outcome was the number of vertigo and headache crises in the 6 months before therapy and in the 6 months of follow-up. Subjects performing Arlevertan© presented during the 6 months of therapy a decrease of vertigo attacks from 5.3 to 2.1 and of headaches from 4.3 to 1.7 (p < 0.0001); 68 % of these subjects reported a decrease of at least 50 % of vertigo attacks, while 63 % of headaches. Conversely, vertigo attacks decreased from 3.5 to 2.2 and headaches from 2.6 to 2 in patients observing only lifestyle; 18 % of these subjects reported a decrease of at least 50 % of vertigo crises and 27 % of headaches. Our data do not differ from those of previous works assessing efficacy of different prophylactic therapies for VM and reporting consistent reduction of vertigo spells in a rate of patients ranging from 60 and 80 %.

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Authors and Affiliations

  1. ENT Division, San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy

    R. Teggi, O. Gatti & M. Bussi

  2. Department of Neurology, San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy

    B. Colombo & G. Comi

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  1. R. Teggi
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  2. B. Colombo
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  3. O. Gatti
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  4. G. Comi
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  5. M. Bussi
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Correspondence to R. Teggi.

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Teggi, R., Colombo, B., Gatti, O. et al. Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study. Neurol Sci 36, 1869–1873 (2015). https://doi.org/10.1007/s10072-015-2270-6

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  • DOI: https://doi.org/10.1007/s10072-015-2270-6

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