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The treatment of fatigue

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Abstract

Fatigue is a psychophysiological state that acts on the subject’s motivation to engage in and/or to continue strenuous physical or cognitive activities. In various pathological conditions fatigue seems to lose this homeostatic function and presents itself as a symptom. The pathophysiology of fatigue is complex and includes neurological (central and peripheral) dysfunction, and altered neurotransmitter, cytokine, and hormonal settings. Treatment interventions are generally based on a sequential approach including treatment of comorbid factors, nonpharmacological treatments, and drugs.

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Authors and Affiliations

  1. Laboratorio Potenziali Evocati, Istituto Neurologico “C. Mondino”, Via Mondino 2, 27100, Pavia, Italy

    Alfredo Romani

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  1. Alfredo Romani
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Correspondence to Alfredo Romani.

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Romani, A. The treatment of fatigue. Neurol Sci 29 (Suppl 2), 247–249 (2008). https://doi.org/10.1007/s10072-008-0952-z

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  • DOI: https://doi.org/10.1007/s10072-008-0952-z

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