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Sleep and its relationship to pain, dysfunction, and disease activity in juvenile idiopathic arthritis

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Abstract

The objective of this study was to determine the sleep abnormalities that may exist in Moroccan children with juvenile idiopathic arthritis (JIA) and their relationship to pain, dysfunction, and disease activity. Case control study including 47 patients diagnosed with JIA, according to the criteria of the International League of Associations for Rheumatology (ILAR), and 47 healthy children, age and sex matched. Sleep was assessed by Children's Sleep Habits Questionnaire (CSHQ). All parents have filled the 45 items of the CSHQ and grouped into eight subscales: bedtime resistance, sleep onset delay, sleep duration, sleep anxiety, sleep-disordered breathing, night awakenings, parasomnias, and morning awakening/daytime sleepiness. The disease activity was assessed by the number of painful joints, swelling joints, erythrocyte sedimentation rate, c-protein reactive, and Juvenile Arthritis Disease Activity Score (JADAS). Functional assessment was based on the value of Childhood Health Assessment Questionnaire. Pain was assessed by visual analog scale pain. Forty-seven patients were included, with 28 males (59.6 %). Children with JIA had a total score of CSHQ significantly higher than the control cases (p < 0.0001); significant differences were also found in the subscale sleep onset delay, sleep anxiety, sleep-disordered breathing, night awakenings, and parasomnias with a p value of <0.0001, 0.034, <0.0001, 0.001, and 0.00, respectively. Significant association was found between the CSHQ total score and visual analog scale (VAS) physician activity (p = 0.016) and JADAS (p = 0.05). There was a correlation between the sleep-disordered breathing and JADAS (p = 0.04). Sleep onset delay was associated with VAS patient pain (p = 0.05), as nocturnal awakenings and VAS patient pain (p = 0.016). Finally, parasomnias and physician's VAS activity (p = 0.015) and VAS patient pain (p = 0.03) were also correlated. This study suggests that sleep abnormalities are common in children with JIA. Strategies to improve sleep should be studied as a possible tool of improving the quality of life of children with rheumatic disease.

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Conficts of interest

The authors have declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Rheumatology, EL Ayachi Hospital, University Hospital of Rabat-Sale, 11000, Sale, Morocco

    S. Shyen, B. Amine, S. Rostom, D. EL Badri, M. Ezzahri, N. Mawani, F. Moussa, S. Gueddari, M. Wabi & N. Hajjaj-Hassouni

  2. Department of Pediatrics, Children’s Hospital, University Hospital of Rabat, 11000, Rabat, Morocco

    B. Chkirate & N. Hajjaj-Hassouni

  3. Laboratory of Biostatistics, Clinical and Epidemiological Research (LBRCE), Faculty of Medicine and Pharmacy, CHU, Rabat, Morocco

    R. Abouqal & N. Hajjaj-Hassouni

Authors
  1. S. Shyen
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  2. B. Amine
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  3. S. Rostom
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  4. D. EL Badri
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  5. M. Ezzahri
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  6. N. Mawani
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  7. F. Moussa
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  8. S. Gueddari
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  9. M. Wabi
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  10. R. Abouqal
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  11. B. Chkirate
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  12. N. Hajjaj-Hassouni
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Correspondence to S. Shyen.

Appendix

Appendix

Table 5 Means, standard deviations (SD) for individual items and subscales for JIA and controls
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Shyen, S., Amine, B., Rostom, S. et al. Sleep and its relationship to pain, dysfunction, and disease activity in juvenile idiopathic arthritis. Clin Rheumatol 33, 1425–1431 (2014). https://doi.org/10.1007/s10067-013-2409-x

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  • DOI: https://doi.org/10.1007/s10067-013-2409-x

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