Skip to main content

Advertisement

Log in

Rehabilitation of chronic whiplash: treatment of cervical dysfunctions or chronic pain syndrome?

  • Review Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Chronic whiplash-associated disorders (WAD) remains a challenging condition for clinicians. There is substantial evidence for the presence of various cervical dysfunctions (e.g., increased cervical muscle tone and impaired cervical movement control), but their contribution to the complex clinical picture of subjects with chronic WAD seems rather limited. There is consistent evidence for increased responsiveness of the central nervous system in those with chronic WAD, and central pain processing is likely to play a crucial role in the transition from an acute whiplash trauma towards chronic WAD. The manuscript explains how our current understanding of chronic WAD can be used to steer the content of conservative interventions and how treatment of cervical dysfunctions in patients with chronic WAD should account for the processes involved in chronicity. It is recommended to prevent sensorimotor incongruence, target cognitive–emotional sensitization, and apply a cognitive behavioral therapy-guided exercise program.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Rodriquez AA, Barr KP, Burns SP (2004) Whiplash: pathophysiology, diagnosis, treatment, and prognosis. Muscle Nerve 29:768–781

    Article  PubMed  Google Scholar 

  2. Spitzer WO, Skovron ML, Salmi LR, Cassidy JD, Duranceau J, Suissa S, Zeiss E (1995) Scientific monograph of the Quebec task force on whiplash-associated disorders: redefining « whiplash » and its management. Spine 20:S1–S73

    Google Scholar 

  3. Kamper SJ, Rebbeck TJ, Maher CG, McAuley JH, Sterling M (2008) Course and prognostic factors of whiplash: a systematic review and meta-analysis. Pain 138:617–629 doi:10.1016/j.pain.2008.02.019

    Article  PubMed  Google Scholar 

  4. Radanov BP, Sturzenegger M (1996) The effect of accident mechanism and initial findings on the long-term outcome of whiplash injury. J Musculoskel Pain 4:47–60

    Article  Google Scholar 

  5. Côté P, Hogg-Johnson S, Cassidy JD et al (2001) The association between neck pain intensity, physical functioning, depressive symptomatology and time-to-claim-closure after whiplash. J Clin Epidemiol 54:275–286

    Article  PubMed  Google Scholar 

  6. Ettlin T, Schuster C, Stoffel R, Brüderlin A, Kischka U (2008) A distinct pattern of myofascial findings in patients after whiplash injury. Arch Phys Med Rehabil 89:1290–1293

    Article  PubMed  Google Scholar 

  7. Woodhouse A, Vasseljen O (2008) Altered motor control patterns in whiplash and chronic neck pain. BMC Musculoskel Dis 9:90 doi:10.1186/1471-2474-9-90

    Article  Google Scholar 

  8. Sterling M, Jull G, Vicenzino B, Kenardy J (2003) Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery. Pain 104:509–517

    Article  PubMed  Google Scholar 

  9. Sterling M, Jull G, Kenardy J (2006) Physical and psychological factors maintain long-term predictive capacity post-whiplash injury. Pain 122:102–108

    Article  PubMed  Google Scholar 

  10. Jull G, Kristjansson E, Dall’Alba P (2004) Impairment in the cervical flexors: a comparison of whiplash and insidious onset neck pain patients. Man Ther 9:89–94

    Article  PubMed  CAS  Google Scholar 

  11. Kongsted A, Sorensen JS, Andersen H, Keseler B, Jensen TS, Bendix T (2008) Are early MRI findings correlated with long-lasting symptoms following whiplash injury? A prospective trial with 1-year follow-up. Eur Spine J 17:996–1005 doi:10.1007/s00586-008-0687-9

    Article  PubMed  Google Scholar 

  12. Miettinen T, Lindgren KA, Airaksinen O, Leino E (2002) Whiplash injuries in Finland: a prospective 1-year follow-up study. Clin Exp Rheumatol 20:399–402

    PubMed  CAS  Google Scholar 

  13. Hol PK (2008) Imaging in whiplash. Cephalalgia 28(S1):25–27

    Article  PubMed  Google Scholar 

  14. Kasch H, Stengaard-Pedersen K, Arendt-Nielsen L, Jensen TS (1994) Headache, neck pain, and neck mobility after acute whiplash injury. A prospective study. Spine 26:1246–1251

    Article  Google Scholar 

  15. Louden JK, Ruhl M, Field E (1997) Ability to reproduce head position after whiplash injury. Spine 22:865–868

    Article  Google Scholar 

  16. Heikkilä HV, Wenngren B-I (1998) Cervicocephalic kinesthetic sensibility, active range of cervical motion, and oculomotor function in patients with whiplash injury. Arch Phys Med Rehabil 79:1089–1094

    Article  PubMed  Google Scholar 

  17. Heikkilä H, Aström P-G (1996) Cervicocephalic kinesthetic sensibility in patients with whiplash injury. Scand J Rehabil Med 28:133–138

    PubMed  Google Scholar 

  18. Treleaven J, Jull G, Sterling M (2003) Dizziness and unsteadiness following whiplash injury: characteristic features and relationship with cervical joint position error. J Rehabil Med 35:36–43

    Article  PubMed  Google Scholar 

  19. Treleaven J, Jull G, Lowchoy N (2005) Standing balance in persistent whiplash: a comparison between subjects with and without dizziness. J Rehabil Med 37:224–229

    Article  PubMed  Google Scholar 

  20. Jull G, Falla D, Treleaven J, Hodges P, Vicenzino B (2007) Retraining cervical joint position sense: the effect of two exercise regimes. J Orthop Res 25:404–412

    Article  PubMed  Google Scholar 

  21. Palmgren PJ, Sandstrom PJ, Lundqvist FJ, Heikkila H (2006) Improvement after chiropractic care in cervicocephalic kinesthetic sensibility and subjective pain intensity in patients with nontraumatic chronic neck pain. J Manipulative Physiol Ther 29:100–106

    Article  PubMed  Google Scholar 

  22. Rogers RG (1997) The effect of spinal manipulation on cervical kinesthesia in patients with chronic neck pain: a pilot study. J Manipulative Physiol Ther 20:80–85

    PubMed  CAS  Google Scholar 

  23. Nederhand MJ, Hermens HJ, Ijzerman MJ, Turk DC, Zivold G (2002) Cervical muscle dysfunction in chronic whiplash-associated disorder grade 2: the relevance of the trauma. Spine 27:1056–1061

    Article  PubMed  Google Scholar 

  24. Montfoort I, Van der Geest JN, Slijper HP, De Zeeuw CI, Frens MA (2008) Adaptation of the cervico- and vestibulo-ocular reflex in whiplash injury patients. J Neurotrauma 25:687–693

    Article  PubMed  Google Scholar 

  25. Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia A-S, McNamara JO (1997) Pain. In: Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia A-S, McNamara JO (eds) Neuroscience. Sinauer, Sunderland, p 167

    Google Scholar 

  26. Ji R-R, Kohno T, Moore KA, Woolf CJ (2003) Central sensitization and LTP: do pain and memory share similar mechanisms. Trends Neurosci 26:696–705

    Article  PubMed  CAS  Google Scholar 

  27. Staud R, Smitherman ML (2002) Peripheral and central sensitization in FM: pathogenic role. Curr Pain Headache Rep 6:259–266

    Article  PubMed  Google Scholar 

  28. Baranauskas G, Nistri A (1998) Sensitization of pain pathways in the spinal cord: cellular mechanisms. Prog Neurobiol 54:349–365

    Article  PubMed  CAS  Google Scholar 

  29. Mendell LM, Wall PD (1965) Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature 206:97–99

    Article  PubMed  CAS  Google Scholar 

  30. Gracely RH, Geisser ME, Giesecke T, Grant MAB, Petzke F, Williams DA, Clauw DJ (2004) Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 127:835–843

    Article  PubMed  CAS  Google Scholar 

  31. Staud R, Craggs JG, Robinson ME, Perlstein WM, Price DD (2007) Brain activity related to temporal summation of C-fiber evoked pain. Pain 129:130–142

    Article  PubMed  Google Scholar 

  32. Meeus M, Nijs J (2007) Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol 26:465–473

    Article  PubMed  Google Scholar 

  33. Nijs J, Van Houdenhove B (2009) From acute musculoskeletal pain to chronic widespread pain and fibromyalgia: Application of pain neurophysiology in manual therapy practice. Manual Therapy 14:3–12 doi:10.1016/j.math.2008.03.001

  34. Meyer RA, Campbell JN, Raja SN (1995) Peripheral neural mechanisms of nociception. In: Wall PD, Melzack R (eds) Textbook of pain. third edn. Churchill Livingstone, Edinburgh, pp 13–44

    Google Scholar 

  35. Sterling M, Treleaven J, Edwards S, Jull G (2002) Pressure pain thresholds in chronic whiplash associated disorder: further evidence of altered central pain processing. J Musculoskel Pain 10:69–81

    Article  Google Scholar 

  36. Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Giani C, Zbinden AM, Radanov BP (2001) Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain 17:306–315

    Article  PubMed  CAS  Google Scholar 

  37. Herren-Gerber R Weiss S, Arendt-Nielsen L, Petersen-Felix S, Di Stefano G, Radanov BP, Curatolo M (2004) Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med 5:366–376

    Article  Google Scholar 

  38. Linnman C, Appel L, Söderlund A, Frans Ö, Engler H, Furmark T, Gordh T, Langström B, Fredrikson M (2008) Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state. Eur J Pain doi:10.1016/j.ejpain.2008.03.001

  39. Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765–1769

    Article  PubMed  CAS  Google Scholar 

  40. Le Bars D, Villaneuva L (1988) Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways. Prog Brain Res 77:275–299

    Article  PubMed  Google Scholar 

  41. Banic B, Petersen-Felix S, Andersen OK, Radanov BP, Villiger PM, Arendt-Nielsen L, Curatolo M (2004) Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 107:7–15

    Article  PubMed  Google Scholar 

  42. Zhuo M (2007) A synaptic model for pain: long-term potentiation in the anterior cingulated cortex. Mol Cells 23:259–271

    PubMed  CAS  Google Scholar 

  43. Davis CG (2000) Injury threshold: whiplash-associated disorders. J Manipulative Physiol Ther 23:420–427

    Article  PubMed  CAS  Google Scholar 

  44. Vierck CJ (2006) Mechanisms underlying development of spatial distributed chronic pain (fibromyalgia). Pain 124:242–263

    Article  PubMed  Google Scholar 

  45. Carstensen TBW, Frostholm L, Oernboel E, Kongsted A, Kasch H, Jensen TS, Fink P (2008) Post-trauma ratings of pre-collision pain and psychological distress predict poor outcome following acute whiplash trauma: a 12-month follow-up study. Pain 139:248–259 doi:10.1016/j.pain.2008.04.008

    Article  PubMed  Google Scholar 

  46. Kasch H, Querama E, Flemming WB, Jensen TS (2005) Reduced cold pressor pain tolerance in non-recovered whiplash patients: a 1-year prospective study. Eur J Pain 9:561–569

    Article  PubMed  Google Scholar 

  47. Jull G, Sterling M, Kenardy J, Beller E (2007) Does the presence of sensory hypersensitivity influence outcomes of physical rehabilitation for chronic whiplash? A preliminary RCT. Pain 129:28–34

    Article  PubMed  CAS  Google Scholar 

  48. Dommerholt J (2005) Persistent myalgia following whiplash. Curr Pain Headache Rep 9:326–330

    Article  PubMed  Google Scholar 

  49. Shah JP, Philips TM, Danoff JV, Gerber LH (2005) An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. J Appl Physiol 99:1977–1984

    Article  PubMed  CAS  Google Scholar 

  50. Benjamin PJ, Tappan FM (2005) Tappan’s handbook of healing massage techniques. Classic, holistic, and emerging methods. Pearson Prentice Hall, Englewood Cliffs, p 127

    Google Scholar 

  51. McCabe CS, Haigh RC, Halligan PW, Blake DR (2005) Simulating sensory-motor incongruence in healthy volunteers: implications for a cortical model of pain. Rheumatol 44:509–516

    Article  CAS  Google Scholar 

  52. McCabe CS, Cohen H, Blake DR (2007) Somaesthetic disturbances in fibromyalgia are exaggerated by sensory-motor conflict: implications for chronicity of the disease. Rheumatol 46:1587–1592

    Article  CAS  Google Scholar 

  53. Stewart MJ, Maher CG, Refshauge KM, Herbert RD, Bogduk N, Nicholas M (2007) Randomized controlled trial of exercise for chronic whiplash-associated disorders. Pain 128:59–68

    Article  PubMed  Google Scholar 

  54. Berglund A, Bodin L, Jensen I, Wiklund A, Alfredsson L (2006) The influence of prognostic factors on neck pain intensity, disability, anxiety and depression over a 2-year period in subjects with acute whiplash injury. Pain 125:244–256

    Article  PubMed  Google Scholar 

  55. Söderlund A, Lindberg P (2003) Whiplash-associated disorders—predicting disability from a process-oriented perspective of coping. Clinical Rehabilitation 17:101–107

    Article  PubMed  Google Scholar 

  56. Börsbo B, Peolsson M, Gerdle B (2008) Catastrophizing, depression, and pain: correlation with and influence on quality of life and health—a study of chronic whiplash-associated disorders. J Rehabil Med 40:562–569

    Article  PubMed  Google Scholar 

  57. Holm LW, Carroll LJ, Cassidy JD, Skillgate E, Ahlbom A (2008) Expectations for recovery important in the prognosis of whiplash injuries. PLoS Med 5:e105 doi:10.1371/journal.pmed.0050105

    Article  PubMed  Google Scholar 

  58. Seminowicz DA, Davies KD (2006) Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain 120:297–306

    Article  PubMed  Google Scholar 

  59. Zusman M (2002) Forebrain-mediated sensitization of central pain pathways: ‘non-specific’ pain and a new image for MT. Man Ther 7:80–88

    Article  PubMed  CAS  Google Scholar 

  60. Ursin H, Eriksen HR (2001) Sensitization, subjective health complaints, and sustained arousal. Annals N Y Acad Sci 933:119–129

    Article  CAS  Google Scholar 

  61. Sullivan MJL, Adams H, Rhodenizer T, Stanish WD (2006) A psychosocial risk factor-targeted intervention for the prevention of chronic pain and disability following whiplash injury. Phys Ther 86:8–18

    PubMed  Google Scholar 

  62. Geisser ME, Roth RS (1998) Knowledge of and agreement with chronic pain diagnosis: relation to affective distress, pain beliefs and coping, pain intensity and disability. J Occup Rehabil 8:73–88

    Article  Google Scholar 

  63. Moseley GL (2002) Combined physiotherapy and education is efficacious for chronic low back pain. Austr J Physiother 48:297–302

    Google Scholar 

  64. Moseley GL, Nicholas MK, Hodges PW (2004) A randomized controlled trial of intensive neurophysiology education in chronic low back pain. Clin J Pain 20:324–330

    Article  PubMed  Google Scholar 

  65. Vendrig AA, van Akkerveeken PF, McWhorter KR (2000) Results of a multimodal treatment program for patients with chronic symptoms after a whiplash injury of the neck. Spine 25:238–244

    Article  PubMed  CAS  Google Scholar 

  66. Moseley GL (2005) Widespread brain activity during and abdominal task markedly reduced after pain physiology education: fMRI evaluation of a single patient with chronic low back pain. Austr J Physiother 51:49–52

    Google Scholar 

  67. Nijs J, Van de Putte K, Louckx F, Truijen S, De Meirleir K (2008) Exercise performance and chronic pain in chronic fatigue syndrome: the role of pain catastrophizing. Pain Med 9:1164–1172

    Article  PubMed  Google Scholar 

  68. Moseley GL (2004) Evidence for a direct relationship between cognitive and physical change during an education intervention in people with chronic low back pain. Eur J Pain 8:39–45

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Jessica Van Oosterwijck is financially supported by grant no. OZR1596 from the research council of the Vrije Universiteit Brussel, Brussels, Belgium. Willem De Hertogh is financially supported by grant no. G815 from the research council of the Artesis University College of Antwerp, Antwerp, Belgium.

Disclosures

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jo Nijs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nijs, J., Van Oosterwijck, J. & De Hertogh, W. Rehabilitation of chronic whiplash: treatment of cervical dysfunctions or chronic pain syndrome?. Clin Rheumatol 28, 243–251 (2009). https://doi.org/10.1007/s10067-008-1083-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-008-1083-x

Keywords

Navigation