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5-HTTLPR variants not associated with autistic spectrum disorders

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To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders.

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Received: August 5, 1998 / Accepted: December 22, 1998 / Published online: March 11, 1999

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Zhong, N., Ye, L., Ju, W. et al. 5-HTTLPR variants not associated with autistic spectrum disorders. Neurogenetics 2, 129–131 (1999). https://doi.org/10.1007/s100480050064

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  • DOI: https://doi.org/10.1007/s100480050064

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