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Cooperative parent-mediated therapy for Italian preschool children with autism spectrum disorder: a randomized controlled trial

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Abstract

Parent-mediated intervention is widely used for pre-schoolers with autism spectrum disorder (ASD). Previous studies indicate small-to-moderate effects on social communication skills, but with a wide heterogeneity that requires further research. In this randomized controlled trial (RCT), cooperative parent-mediated therapy (CPMT) an individual parent coaching program for young children with ASD was administered to preschool children with ASD. All children received the same low-intensity psychosocial intervention (LPI) delivered in community settings, to evaluate the potential additional benefit of CPMT. Thirty-four participants with ASD (7 females; 27 males; aged 2, 6, 11 years) and their parents were included in the trial. The primary blinded outcome was social communication skills, assessed using the ADOS-G social communication algorithm score (ADOS-G SC). Secondary outcomes included ASD symptom severity, parent-rated language abilities and emotional/behavioral problems, and self-reported caregiver stress. Evaluations were made at baseline and post-treatment (at 6 months) by an independent multidisciplinary team. Results documented that CPMT showed an additional benefit on LPI with significant improvements of the primary blinded outcome, socio-communication skills, and of some secondary outcomes such as ASD symptom severity, emotional problems and parental stress related to parent–child dysfunctional interaction. No additional benefit was found for language abilities. Findings of our RCT show that CPMT provide an additional significant short-term treatment benefit on ASD core symptoms, when compared with active control group receiving only LPI.

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Acknowledgements

We thank the families that participated in this study.

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Authors and Affiliations

  1. Department of Neuroscience, IRCCS Children’s Hospital Bambino Gesù, Piazza Sant’ Onofrio, 4 00165, Rome, Italy

    Giovanni Valeri, Laura Casula, Deny Menghini, Filomena Alessandra Amendola, Eleonora Napoli & Stefano Vicari

  2. Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy

    Patrizio Pasqualetti

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  1. Giovanni Valeri
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  2. Laura Casula
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  3. Deny Menghini
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Correspondence to Stefano Vicari.

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Valeri, G., Casula, L., Menghini, D. et al. Cooperative parent-mediated therapy for Italian preschool children with autism spectrum disorder: a randomized controlled trial. Eur Child Adolesc Psychiatry 29, 935–946 (2020). https://doi.org/10.1007/s00787-019-01395-5

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