Abstract
Research exploring the effects of prenatal maternal depression on a developing fetus and child is underrepresented in the literature. Empirical papers have typically focused on the effects of postpartum depression (after birth) instead of prepartum depression (before birth). Disparate empirical findings have produced ongoing debate regarding the effects of prenatal depression on a developing fetus and later in infancy and early childhood. Even more controversial is determining the role of antidepressant medication on offspring outcomes and whether research that does not include the proper control population (e.g., unmedicated depressed participants) can adequately address questions about risks and benefits of treatment during pregnancy. The current review systematically summarizes the literature focusing on unmedicated prenatal depression and offspring outcome and concludes that prepartum depression is highly prevalent, is associated with negative outcomes in offspring, and remains understudied.
Similar content being viewed by others
Notes
Prepartum, prenatal, and antenatal will be used interchangeably in the present paper and refer to period of time before birth. Similarly, antepartum, postpartum and postnatal will be used interchangeably.
References
Allister L, Lester BM, Carr S, Liu J (2001) The effects of maternal depression on fetal heart rate response to vibroacoustic stimulation. Dev Neuropsychol 20:639–651
Cohen J (1992) A power primer. Psych Bull 112:155–159
Cole PM, Zahn-Waxler C, Fox NA, Usher BA, Welsh JD (1996) Individual differences in emotion regulation and behavior problems in preschool children. J Abnorm Psychol 105:518–529
Davey Smith G, Hart C, Upton M, Hole D, Gillis C, Watt G, Hawthorne V (2000) Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality. J Epidem Community Health 54:97–103
Davidson RJ (2000) Affective style, psychopathology, and resilience: brain mechanisms and plasticity. Am Psychol 55:1196–1214
Dayan J, Creveuil C, Marks MN, Conroy S, Herlicoviez M, Dreyfus M, Tordjman S (2006) Prenatal depression, prenatal anxiety, and spontaneous preterm birth: a prospective cohort study among women with early and regular care. Psychosom Med 68:938–946
Diego MA, Field T, Hernandez-Reif M, Cullen C, Schanberg S, Kuhn C (2004) Prepartum, postpartum, and chronic depression effects on newborns. Psychiatry 67:63–80
Diego MA, Field T, Hernandez-Reif M (2005) Prepartum, postpartum and chronic depression effects on neonatal behavior. Infant Behav Dev 28:155–164
Diego MA, Field T, Hernandez-Reif M, Schanberg S, Kuhn C, Gonzalez-Quintero VH (2009) Prenatal depression restricts fetal growth. Early Hum Dev 85:65–70
Elgar FJ, McGrath PJ, Waschbusch DA, Stewart SH, Curtis LJ (2004) Mutual influences on maternal depression and child adjustment problems. Clin Psychol Rev 24:441–459
Ertel KA, Koenen KC, Rich-Edwards JW, Gillman MW (2010a) Maternal depressive symptoms not associated with reduced height in young children in a US prospective cohort study. PLoS One 5(10):e13656
Ertel KA, Koenen KC, Rich-Edwards JW, Gillman MW (2010b) Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity. Paed Perinatal Epidem 24:179–189
Evans J, Heron J, Francomb H, Oke S, Golding J (2001) Cohort study of depressed mood during pregnancy and after childbirth. Brit Med J 323:257–260
Field T (2010) Prenatal depression and selective serotonin reuptake inhibitors. Int J Neurosci 120:163–167
Field T, Diego M, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D (2002) Prenatal depression effects on the foetus and neonate in different ethnic and socio-economic status groups. J Reprod Infant Psychol 20:149–157
Field T, Diego M, Dieter J, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D (2004) Prenatal depression effects on the fetus and the newborn. Infant Behav Dev 27:216–229
Field T, Diego M, Hernandez-Reif M, Figueiredo B, Schanberg S, Kuhn C (2008) Chronic prenatal depression and neonatal outcome. Int J Neurosci 118:95–103
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T (2005) Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol 106:1071–1083
Gillman M, Rich-Edwards JW, Huh S, Majzoub JA, Oken E, Taveras EM, Rifas-Shiman SL (2006) Maternal corticoptropin-releasing hormone levels during pregnancy and offspring adiposity. Obesity 14:1647–1653
Goodman J, Santangelo G (2011) Group treatment for postpartum depression: a systematic review. Arch Women’s Ment Health 14:277–293
Gotlib IH, Whiffen VE, Mount JH, Milne K, Cordy NI (1989) Prevalence rates and demographic characteristics associated with depression in pregnancy and the postpartum. J Consult Clin Psychol 57:269–274
Groome LJ, Watson JE, Dykman RA (1994) Heart rate changes following habituation testing of the motor responses in normal human fetuses. Early Hum Dev 36:69–77
Grush LR, Cohen LS (1998) Treatment of depression during pregnancy: balancing the risks. Harvard Rev Psychiat 6:105–109
Leonardi-Bee J, Smyth A, Britton J, Coleman T (2008) Environmental tobacco smoke and fetal health: systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 93:351–361
Marcus SM, Flynn HA, Blow F, Barry K (2005) A screening study of antidepressant treatment rates and mood symptoms in pregnancy. Arch Women Ment Health 8:25–27
Misri S, Kendrick K (2007) Treatment of perinatal mood and anxiety disorders: a review. Canadian J Psychiatr 52:489–498
Oberlander T, Warburton W, Misri S, Aghajanian J, Hertzman C (2006) Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiat 63:898–906
Porges SW (1992) Vagal tone: a physiologic marker of stress vulnerability. Pediatric 90:498–504
Rahman A, Iqbal Z, Bunn J, Lovel H, Harrington R (2004) Impact of maternal depression on infant nutritional status and illness. Arch Gen Psychiat 61:946–952
Sandman CA, Wadhwa PD, Dunkel-Schetter C (1994) Psychobiological influences of stress and HPA regulation on the human fetus and infant birth outcomes. Ann NY Acad Sci 739:198–210
Steer RA, Scholl TO, Hediger ML, Fischer RL (1992) Self-reported depression and negative pregnancy outcomes. J Clin Epid 45:1093–1099
Suppaseemanont W (2006) Depression in Pregnancy: drug safety and nursing management. Amer J Maternal/Child Nurs 31:10–15
Suri R, Altshuler L, Hendrick V, Rasgon N, Lee E, Mintz J (2004) The impact of depression and fluoxetine treatment on obstetrical outcome. Arch Women Ment Health 7:193–200
Thayer JF, Friedman BH, Borkovec TD (1996) Autonomic characteristics of generalized anxiety disorder and worry. Biol Psychiatry 39:255–266
World Health Organization (2001) A message from the Director General. Available from: URL: http://www.who.int/whr/2001/dg_message/en/index.html
Acknowledgments
This work was supported by the National Alliance for Research on Schizophrenia and Depression (NARSAD). Special thanks to Brett Sharpe for help with database searches.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Davalos, D.B., Yadon, C.A. & Tregellas, H.C. Untreated prenatal maternal depression and the potential risks to offspring: a review. Arch Womens Ment Health 15, 1–14 (2012). https://doi.org/10.1007/s00737-011-0251-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00737-011-0251-1