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Instruments for holistic assessment of Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Assessment of Parkinson’s disease is a complex matter as a consequence of the variety of manifestations and complications that can be present in a patient. Although a really holistic assessment is probably a utopia, a comprehensive evaluation is possible using a combination of measures completed by health professionals, patients and/or caregivers. In PD, main domains requiring assessment include motor impairment, motor complications, non-motor symptoms, disability, and patient-reported outcomes. Such scales like the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale and the battery of Scales for Outcomes in Parkinson’s disease (SCOPA) provide a wide information on the most relevant aspects of the disease. Hoehn and Yahr staging, global impression, and quality of life measures furnish summarized whole evaluations and comprehensive non-motor symptom assessments help to identify and evaluate this kind of manifestations. This article shows a pragmatic review of common instruments (rating scales and questionnaires) usable for a comprehensive assessment of PD and provides information about sources for guiding the selection of measures and outcome analyses.

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References

  • Antonini A, Abbruzzese G, Ferini-Strambi L et al (2012) Validation of the Italian version of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale. Neurol Sci. doi:10.1007/s10072-012-1112-z

    Google Scholar 

  • Bech P (1993) Rating scales for psychopathology, health status, and quality of life. Springer, Berlin, pp 33–35

    Book  Google Scholar 

  • Bowling A (2005) Measuring health. A review of quality of life measurement scales. Open University Press, Berkshire

    Google Scholar 

  • Chaudhuri KR, Martinez-Martin P, Schapira AH et al (2006) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21:916–923

    Article  PubMed  Google Scholar 

  • Chaudhuri KR, Martinez-Martin P, Brown RG et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22:1901–1911

    Article  PubMed  Google Scholar 

  • Evatt ML, Chaudhuri KR, Chou KL et al (2009) Dysautonomia rating scales in Parkinson’s disease: sialorrhea, dysphagia, and constipation—critique and recommendations by Movement Disorders Task Force on rating scales for Parkinson’s disease. Mov Disord 24:635–646

    Article  PubMed  Google Scholar 

  • Fahn S, Elton RL, Members of the UPDRS Development Committee (1987) Unified Parkinson’s Disease Rating Scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease, vol 2. Macmillan Healthcare Information, Florham Park, pp 153–164

  • Friedberg G, Zoldan J, Weizman A, Melamed E (1998) Parkinson Psychosis Rating Scale: a practical instrument for grading psychosis in Parkinson’s disease. Clin Neuropharmacol 21:280–284

    PubMed  CAS  Google Scholar 

  • Gallagher DA, Goetz CG, Stebbins G et al (2012) Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson’s disease. Mov Disord 27:79–83

    Article  PubMed  Google Scholar 

  • Goetz CG, Poewe W, Rascol O et al (2004) Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 19:1020–1028

    Article  PubMed  Google Scholar 

  • Goetz CG, Fahn S, Martinez-Martin P et al (2007) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): process, format and clinimetric testing plan. Mov Disord 22:41–47

    Article  PubMed  Google Scholar 

  • Goetz CG, Tilley BC, Shaftman SR et al (2008) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23:2129–2170

    Article  PubMed  Google Scholar 

  • Guy W (1976). Early Clinical Drug Evaluation Unit (ECDEU) assessment manual for psychopharmacology. Revised. NIMH publication DHEW publ NO (Adm) 76-338. National Institute of Mental Health, Bethesda, pp 217–222

  • Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression, and mortality. Neurology 17:427–442

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson C, Fitzpatrick R, Peto V et al (1997a) The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing 26:353–357

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson C, Fitzpatrick R, Peto V (1997b) The PDQ-8: development and validation of a short-form Parkinson’s Disease Questionnaire. Psychol Health 12:805–814

    Article  Google Scholar 

  • Marinus J, Visser M, Martinez-Martin P et al (2003a) A short psychosocial questionnaire for patients with Parkinson’s disease: the SCOPA-PS. J Clin Epidemiol 56:61–67

    Article  PubMed  Google Scholar 

  • Marinus J, Visser M, van Hilten JJ et al (2003b) Assessment of sleep and sleepiness in Parkinson disease. Sleep 26:1049–1054

    PubMed  Google Scholar 

  • Marinus J, Visser M, Verwey NA et al (2003c) Assessment of cognition in Parkinson’s disease. Neurology 61:1222–1228

    Article  PubMed  CAS  Google Scholar 

  • Marinus J, Visser M, Stiggelbout AM et al (2004) A short scale for the assessment of motor impairments and disabilities in Parkinson’s disease: the SPES/SCOPA. J Neurol Neurosurg Psychiatry 75:388–395

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Martin P (2010) Composite rating scales. J Neurol Sci 289:7–11

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Kurtis MM (2012) Health-related quality of life as an outcome variable in Parkinson’s disease. Ther Adv Neurol Disord 5:105–117

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Forjaz MJ, Cubo E, Frades B (2006) Global versus factor-related impression of severity in Parkinson’s disease: a new clinimetric index (CISI-PD). Mov Disord 21:208–214

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Schapira AH, Stocchi F et al (2007) Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting: study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 22:1623–1629

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Rodriguez-Blazquez C, Abe K et al (2009a) International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. Neurology 73:1584–1591

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ et al (2009b) The clinical impression of Severity Index for Parkinson’s disease: international validation study. Mov Disord 24:211–217

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Jeukens-Visser M, Lyons KE et al (2011) Health-related Quality of Life Scales in Parkinson’s Disease: critique and recommendations. Mov Disord 26:2371–2380

    Article  PubMed  Google Scholar 

  • Martinez-Martin P, Rodriguez-Blazquez C, Alvarez-Sanchez M et al (2013) Expanded and independent validation of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). J Neurol 260:228–236

    Article  PubMed  Google Scholar 

  • Mokkink LB, Terwee CB, Knol DL et al (2010) The COSMIN checklist for evaluating the methodological quality of studies on measurement properties: a clarification of its content. BMC Med Res Methodol 10:22

    Article  PubMed  Google Scholar 

  • Movement Disorder Society Task Force on Rating Scales for Parkinson’s Disease (2003) The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 18:738–750

    Article  Google Scholar 

  • Peto V, Jenkinson C, Fitzpatrick R, Greenhall R (1995) The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res 4(3):241–248

    Article  PubMed  CAS  Google Scholar 

  • Rabey JM, Baas H, Bonuccelli U et al (1997) Evaluation of the Short Parkinson’s Evaluation Scale: a new friendly scale for the evaluation of Parkinson’s disease in clinical drug trials. Clin Neuropharmacol 20:322–337

    Article  PubMed  CAS  Google Scholar 

  • Sherbourne CD, Sturm R, Wells KB (1999) What outcomes matter to patients? J Gen Intern Med 14:357–363

    Article  PubMed  CAS  Google Scholar 

  • The EuroQol Group (1990) EuroQol—a new facility for the measurement of health related quality of life. Health Policy 16:199–208

    Article  Google Scholar 

  • Visser M, Marinus J, Stiggelbout AM, van Hilten JJ (2004) Assessment of autonomic dysfunction in Parkinson’s disease: the SCOPA-AUT. Mov Disord 19:1306–1312

    Google Scholar 

  • Visser M, Verbaan D, van Rooden SM et al (2007) Assessment of psychiatric complications in Parkinson’s disease: the SCOPA-PC. Mov Disord 22:2221–2228

    Article  PubMed  Google Scholar 

  • Wyrwich KW, Norquist JM, Lenderking WR et al (2012) Methods for interpreting change over time in patient-reported outcome measures. Qual Life Res. doi:10.1007/s11136-012-0175-x

    Google Scholar 

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Authors and Affiliations

  1. Research Unit, Alzheimer Center Reina Sofia Foundation, C/. Valderrebollo, 5, 28031, Madrid, Spain

    Pablo Martinez-Martin

  2. CIBERNED, Carlos III Institute of Health, Madrid, Spain

    Pablo Martinez-Martin

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  1. Pablo Martinez-Martin
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Correspondence to Pablo Martinez-Martin.

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Martinez-Martin, P. Instruments for holistic assessment of Parkinson’s disease. J Neural Transm 120, 559–564 (2013). https://doi.org/10.1007/s00702-013-1005-1

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  • DOI: https://doi.org/10.1007/s00702-013-1005-1

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