Abstract
A time-processing deficit has been proposed as a neuropsychological candidate endophenotype for Attention Deficit Hyperactivity Disorder (ADHD), but its developmental trajectory still needs to be explored. In the present study, children (N = 33) and adults (N = 22) with ADHD were compared to normal controls on two time-processing tasks. For time reproduction, ADHD-related impairment was found in the full group, but not when adults were analyzed separately. For the discrimination of brief intervals, children and adults with ADHD showed different patterns of deficit. We conclude that in ADHD some time-processing deficits are still present in adults, but may take on age-related different forms.
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Balint S, Czobor P, Komlosi S, Meszaros A, Simon V, Bitter I (2009) Attention deficit hyperactivity disorder (ADHD): gender- and age-related differences in neurocognition. Psychol Med 39:1337–1345
Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121:65–94
Barkley RA, Koplowitz S, Anderson T, McMurray MB (1997) Sense of time in children with ADHD: effects of duration, distraction, and stimulant medication. J Int Neuropsychol Soc 3:359–369
Barkley RA, Edwards G, Laneri M, Fletcher K, Metevia L (2001a) Executive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). J Abnorm Child Psychol 29:541–556
Barkley RA, Murphy KR, Bush T (2001b) Time perception and reproduction in young adults with attention deficit hyperactivity disorder. Neuropsychology 15:351–360
Bekker EM, Overtoom CC, Kooij JJ, Buitelaar JK, Verbaten MN, Kenemans JL (2005) Disentangling deficits in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 62(10):1129–1136
Biederman J, Spencer T (1999) Attention-deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46:1234–1242
Biederman J, Petty CR, Fried R, Doyle AE, Spencer T, Seidman LJ et al (2007) Stability of executive function deficits into young adult years: a prospective longitudinal follow-up study of grown up males with ADHD. Acta Psychiatr Scand 116:129–136
Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK (2005) Executive functioning in adult ADHD: a meta-analytic review. Psychol Med 35:1097–1108
Brandeis D, Banaschewski T, Baving L, Georgiewa P, Blanz B, Warnke A et al (2002) Multicenter P300 brain mapping of impaired attention to cues in hyperkinetic children. J Am Acad Child Adolesc Psychiatry 41:990–998
Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N et al (2006) The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934–953
Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS et al (2002) Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 288:1740–1748
Castellanos FX, Sonuga-Barke EJ, Scheres A, Di Martino A, Hyde C, Walters JR (2005) Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biol Psychiatry 57:1416–1423
Chen W, Taylor E (2006) PACS Interview and genetic research of ADHD. In: Oades RD (ed) Attention deficit/hyperactivity disorder HKS: current ideas and ways forward. Nova Science Publishers, New York, pp 3–20
Christiansen H, Chen W, Oades RD, Asherson P, Taylor EA, Lasky-Su J et al (2008) Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder. J Neural Transm 115:163–175
Conners CK, Sitarenios G, Parker JD, Epstein JN (1998a) The revised Conners’ Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257–268
Conners CK, Sitarenios G, Parker JD, Epstein JN (1998b) Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:279–291
Derogatis LR (1994) Symptom Checklist-90-R: administrative scoring and procedures manual. NCS Pearson, Minneapolis
Di Martino A, Ghaffari M, Curchack J, Reiss P, Hyde C, Vannucci M et al (2008) Decomposing intra-subject variability in children with attention-deficit/hyperactivity disorder. Biol Psychiatry 64:607–614
Doehnert M, Brandeis D, Straub M, Steinhausen H-C, Drechsler R (2008) Slow cortical potential neurofeedback in attention deficit hyperactivity disorder: is there neurophysiological evidence for specific effects? J Neural Transm 115:1445–1456
Drechsler R, Brandeis D, Földenyi M, Imhof K, Steinhausen H-C (2005) The course of neuropsychological functions in children with attention deficit/hyperactivity disorder from late childhood into early adolescence. J Child Psychol Psychiatry 46:824–836
Drechsler R, Rizzo P, Steinhausen H-C (2009) The clinical validity of a computerized test battery for attentional performance for children (KITAP) in the diagnosis of ADHD in children aged 7–10 years. Kindheit Entwicklung 18:153–161
Droit-Volet S, Delgado M, Rattat A-C (2006) The development of the ability to judge time in children. In: Marrow JR (ed) Focus on child psychology research. Nova Science, New York, pp 81–104
Durston S, de Zeeuw P, Staal WG (2009) Imaging genetics in ADHD: a focus on cognitive control. Neurosci Biobehav Rev 33:674–689
Faraone SV, Doyle AE, Mick E, Biederman J (2001) Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 158:1052–1057
Földenyi M, Imhof K, Steinhausen H-C (2000) Clinical validity of the TAP for the assessment of ADHD-children. Zeitschrift Neuropsychol 11:154–167
Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG (1999) Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283:397–401
Geurts HM, Grasman RP, Verte S, Oosterlaan J, Roeyers H, van Kammen SM et al (2008) Intra-individual variability in ADHD, autism spectrum disorders and Tourette’s syndrome. Neuropsychologia 46:3030–3041
Giedd JN, Blumenthal J, Molloy E, Castellanos FX (2001) Brain imaging of attention deficit/hyperactivity disorder. Ann N Y Acad Sci 931:33–49
Gilden DL, Marusich LR (2009) Contraction of time in attention-deficit hyperactivity disorder. Neuropsychology 23:265–269
Goodman R (1997) The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry 38:581–586
Halperin JM, Schulz KP (2006) Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychol Bull 132:560–581
Halperin JM, Trampush JW, Miller CJ, Marks DJ, Newcorn JH (2008) Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. J Child Psychol Psychiatry 49:958–966
Harrington DL, Haaland KY, Hermanowicz N (1998) Temporal processing in the basal ganglia. Neuropsychology 12:3–12
Hervey AS, Epstein JN, Curry JF (2004) Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review. Neuropsychology 18:485–503
Himpel S, Banaschewski T, Gruttner A, Becker A, Heise A, Uebel H et al (2009) Duration discrimination in the range of milliseconds and seconds in children with ADHD and their unaffected siblings. Psychol Med 39:1745–1751
Ivry RB (1996) The representation of temporal information in perception and motor control. Curr Opin Neurobiol 6:851–857
Karmarkar UR, Buonomano DV (2007) Timing in the absence of clocks: encoding time in neural network states. Neuron 53:427–438
Kelly AM, Margulies DS, Castellanos FX (2007) Recent advances in structural and functional brain imaging studies of attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 9:41–407
Kieling C, Goncalves RR, Tannock R, Castellanos FX (2008) Neurobiology of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17:285–307, viii
King JA, Colla M, Brass M, Heuser I, von Cramon D (2007) Inefficient cognitive control in adult ADHD: evidence from trial-by-trial Stroop test and cued task switching performance. Behav Brain Funct 3:42
Klimkeit EI, Mattingley JB, Sheppard DM, Lee P, Bradshaw JL (2005) Motor preparation, motor execution, attention, and executive functions in attention deficit/hyperactivity disorder (ADHD). Child Neuropsychol 11:153–173
Koschack J, Kunert HJ, Derichs G, Weniger G, Irle E (2003) Impaired and enhanced attentional function in children with attention deficit/hyperactivity disorder. Psychol Med 33:481–489
Lefly DL, Pennington BF (2000) Reliability and validity of the Adult Reading History Questionnaire. J Learn Disabil 33:286–296
Lewis PA, Miall RC (2003a) Brain activation patterns during measurement of sub- and supra-second intervals. Neuropsychologia 41:1583–1592
Lewis PA, Miall RC (2003b) Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging. Curr Opin Neurobiol 13:250–255
Lewis PA, Miall RC (2006) Remembering the time: a continuous clock. Trends Cogn Sci 10:401–406
Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ et al (2004) Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. Am J Hum Genet 74:348–356
Madison G (2001) Variability in isochronous tapping: higher order dependencies as a function of intertap interval. J Exp Psychol Hum Percept Perform 27:411–422
Mangels JA, Ivry RB (2001) Time perception. In: Rapp B (ed) The handbook of cognitive neuropsychology: what deficits reveal about the human mind. Psychology Press, Pennsylvania
Mangels JA, Ivry RB, Shimizu N (1998) Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. Brain Res Cogn Brain Res 7:15–39
Marx I, Hübner T, Herpertz SC, Berger C, Reuter E, Kircher T, Herpertz-Dahlmann B, Konrad K (2010) Cross-sectional evaluation of cognitive functioning in children, adolescents and young adults with ADHD. J Neural Transm 117:403–419
McInerney RJ, Kerns KA (2003) Time reproduction in children with ADHD: motivation matters. Child Neuropsychol 9:91–108
Meaux JB, Chelonis JJ (2003) Time perception differences in children with and without ADHD. J Pediatr Health Care 17:64–71
Radonovich KJ, Mostofsky SH (2004) Duration judgments in children with ADHD suggest deficient utilization of temporal information rather than general impairment in timing. Child Neuropsychol 10:162–172
Retz-Junginger P, Retz W, Blocher D, Stieglitz RD, Georg T, Supprian T et al (2003) Reliability and validity of the Wender-Utah-Rating-Scale short form. Retrospective assessment of symptoms for attention deficit/hyperactivity disorder. Nervenarzt 74:87–993
Rhee SH, Waldman ID, Hay DA, Levy F (1999) Sex differences in genetic and environmental influences on DSM-III-R attention-deficit/hyperactivity disorder. J Abnorm Psychol 108:24–41
Roesler M, Retz W, Retz-Junginger P, Thome J, Supprian T, Nissen T et al (2004) Tools for the diagnosis of attention-deficit/hyperactivity disorder in adults. Self-rating behaviour questionnaire and diagnostic checklist. Nervenarzt 75:888–895
Rommelse NN, Oosterlaan J, Buitelaar J, Faraone SV, Sergeant JA (2007) Time reproduction in children with ADHD and their nonaffected siblings. J Am Acad Child Adolesc Psychiatry 46:582–590
Rosvold HE, Mirsky HF, Sarason I, Bransome ED, Beck LH (1956) A continuous performance test of brain damage. J Consult Psychol 20:343–350
Rothenberger A (2009) Brain oscillations forever—neurophysiology in future research of child psychiatric problems. J Child Psychol Psychiatry 50:79–86
Rubia K, Noorloos J, Smith A, Gunning B, Sergeant J (2003) Motor timing deficits in community and clinical boys with hyperactive behavior: the effect of methylphenidate on motor timing. J Abnorm Child Psychol 31:301–313
Schallberger U (2005) Welches sind die nach statistischen Kriterien besten Kurzformen des HAWIK-III? Research Report. University of Zurich
Scheres A, Oosterlaan J, Geurts H, Morein-Zamir S, Meiran N, Schut H et al (2004) Executive functioning in boys with ADHD: primarily an inhibition deficit? Arch Clin Neuropsychol 19:569–594
Schoechlin C, Engel RR (2005) Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data. Arch Clin Neuropsychol 20:727–744
Seidman LJ (2006) Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev 26:466–485
Sergeant J (2000) The cognitive-energetic model: an empirical approach to attention-deficit hyperactivity disorder. Neurosci Biobehav Rev 24:7–12
Seri Y, Kofman O, Shay L (2002) Time estimation could be impaired in male, but not female adults with attention deficits. Brain Cogn 48:553–558
Sherman DK, Iacono WG, McGue MK (1997) Attention-deficit hyperactivity disorder dimensions: a twin study of inattention and impulsivity-hyperactivity. J Am Acad Child Adolesc Psychiatry 36:745–753
Smith AB, Taylor E, Rogers JW, Newman S, Rubia K (2002) Evidence for a pure time perception deficit in children with ADHD. J Child Psychol Psychiatry 43:529–542
Smith AB, Taylor E, Brammer M, Halari R, Rubia K (2008) Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naive adolescents with attention deficit hyperactivity disorder during time discrimination. J Child Psychol Psychiatry 49:977–985
Sonuga-Barke EJ (2002) Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition. Behav Brain Res 130:29–36
Sonuga-Barke EJ, Saxton T, Hall M (1998) The role of interval underestimation in hyperactive children’s failure to suppress responses over time. Behav Brain Res 94:45–50
Sonuga-Barke EJ, Sergeant JA, Nigg J, Willcutt E (2008) Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications. Child Adolesc Psychiatr Clin N Am 17:67–384, ix
Sonuga-Barke EJ, Bitsakou P, Thompson M (2010) Beyond the dual pathway model: evidence for the dissociation of timing, inhibitory, and delay-related impairments in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:345–355
Suskauer SJ, Simmonds DJ, Caffo BS, Denckla MB, Pekar JJ, Mostofsky SH (2008) FRI of intrasubject variability in ADHD: anomalous premotor activity with prefrontal compensation. J Am Acad Child Adolesc Psychiatry [Epub Aug 21]
Suskauer SJ, Simmonds DJ, Fotedar S, Blankner JG, Pekar JJ, Denckla MB et al (2008b) Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response. J Cogn Neurosci 20:478–493
Taylor E, Schachar R, Thorley G, Wieselberg M (1986) Conduct disorder and hyperactivity. I. Separation of hyperactivity and antisocial conduct in British child psychiatric patients. Br J Psychiatry 149:760–767
Tewes U (1991) HAWIE-R Hamburg-Wechsler Intelligenztest für Erwachsene. Huber, Bern
Tucha L, Tucha O, Laufkotter R, Walitza S, Klein HE, Lange KW (2008) Neuropsychological assessment of attention in adults with different subtypes of attention-deficit/hyperactivity disorder. J Neural Transm 115:269–278
Valera EM, Spencer RM, Zeffiro TA, Makris N, Spencer TJ, Faraone SV, Biederman J, Seidman LJ (2010) Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder. Biol Psychiatry [Epub Jul 8]
Valko L, Doehnert M, Mueller U, Schneider G, Drechsler R, Maechler M, Steinhausen HC, Brandeis D (2009) Differences in neurophysiological markers of inhibitory and temporal processing deficits in children and adults with ADHD. J Psychophysiol 23:212–223
van der Meere JJ (2005) State regulation and ADHD. In: Gozal D, Molfese DL (eds) From genes to patients. Humana Press, Totowa, NJ, pp 413–433
van der Meere JJ, Shalev RS, Borger N, Wiersema JR (2009) Methylphenidate, interstimulus interval, and reaction time performance of children with attention deficit/hyperactivity disorder: a pilot study. Child Neuropsychol 15:554–566
van Leeuwen TH, Steinhausen HC, Overtoom CC, Pascual-Marqui RD, van’t Klooster B, Rothenberger A et al (1998) The continuous performance test revisited with neuroelectric mapping: impaired orienting in children with attention deficits. Behav Brain Res 94:97–110
Vaurio RG, Simmonds DJ, Mostofsky SH (2009) Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands. Neuropsychologia 47:2389–2396
Vloet TD, Gilsbach S, Neufang S, Fink GR, Herpertz-Dahlmann B, Konrad K (2010) Neural mechanisms of interference control and time discrimination in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:356–367
Willis WG, Weiler MD (2005) Neural substrates of childhood attention-deficit/hyperactivity disorder: electroencephalographic and magnetic resonance imaging evidence. Dev Neuropsychol 27:135–182
Zimmermann P, Fimm B (2002) Test for attentional performance TAP, version 1.7. Herzogenrath, Psytest
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This study was supported by the Swiss National Science Foundation grant 32-109591 to H.-C. Steinhausen. The recruitment of ADHD sib pairs was supported by the National Institute of Mental Health Grant R01MH062873 to Steve Faraone. We thank the children and their families for participation.
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Valko, L., Schneider, G., Doehnert, M. et al. Time processing in children and adults with ADHD. J Neural Transm 117, 1213–1228 (2010). https://doi.org/10.1007/s00702-010-0473-9
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DOI: https://doi.org/10.1007/s00702-010-0473-9