Skip to main content
SpringerLink
Log in

Development of a Patient Questionnaire to facilitate recognition of motor and non-motor wearing-off in Parkinson’s disease

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

We previously reported that the use of a specifically designed Wearing-Off Questionnaire (WOQ) identified symptoms of wearing-off more frequently than standard assessments conducted by movement disorder specialists during a routine office visit. In the previous study we used a WOQ of 32 symptoms; however this tool was not designed for daily use. In this paper we describe the retrospective development of a simpler, 19-symptom WOQ more suitable for routine clinical use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Y Agid CW Olanow Y Mizuno (2002) ArticleTitleLevodopa: why the controversy Lancet 360 575 Occurrence Handle12241695 Occurrence Handle10.1016/S0140-6736(02)09733-7 Occurrence Handle1:STN:280:DC%2BD38vnvVShuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JE Ahlskog MD Muenter (2001) ArticleTitleFrequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature Mov Disord 16 448–458 Occurrence Handle11391738 Occurrence Handle10.1002/mds.1090 Occurrence Handle1:STN:280:DC%2BD3MzitVCmtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • KR Chaudhuri L Yates P Martinez-Martin (2005) ArticleTitleThe non-motor symptom complex of Parkinson’s disease: a comprehensive assessment is essential Curr Neurol Neurosci Rep 5 275–283 Occurrence Handle15987611

    PubMed  Google Scholar 

  • RC Dodel K Berger WH Oertel (2001) ArticleTitleHealth-related quality of life and healthcare utilisation in patients with Parkinson’s disease: impact of motor fluctuations and dyskinesias Pharmacoeconomics 19 1013–1038 Occurrence Handle11735671 Occurrence Handle10.2165/00019053-200119100-00004 Occurrence Handle1:STN:280:DC%2BD38%2Fjtlaruw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CG Goetz W Poewe O Rascol C Sampaio (2005) ArticleTitleEvidence-based medical review update: pharmacological and surgical treatments of Parkinson’s disease: 2001 to 2004 Mov Disord 20 523–539 Occurrence Handle15818599 Occurrence Handle10.1002/mds.20464

    Article  PubMed  Google Scholar 

  • CD Marsden JD Parkes (1977) ArticleTitleSuccess and problems of long-term levodopa therapy in Parkinson’s disease Lancet 1 345–349 Occurrence Handle64868 Occurrence Handle10.1016/S0140-6736(77)91146-1 Occurrence Handle1:STN:280:CSiD1MbhtVU%3D

    Article  PubMed  CAS  Google Scholar 

  • CW Olanow F Stocchi (2004) ArticleTitleCOMT inhibitors in Parkinson’s disease: can they prevent and/or reverse levodopa-induced motor complications? Neurology 62 IssueIDSuppl 1 S72–S81 Occurrence Handle14718683 Occurrence Handle1:CAS:528:DC%2BD2cXhsFWgtbs%3D

    PubMed  CAS  Google Scholar 

  • InstitutionalAuthorNameParkinson Study Group (1996) ArticleTitleImpact of deprenyl and tocopherol treatment on Parkinson’s disease in DATATOP patients not requiring levodopa Ann Neurol 39 29–36 Occurrence Handle10.1002/ana.410390106

    Article  Google Scholar 

  • InstitutionalAuthorNameParkinson Study Group (2000) ArticleTitlePramipexole vs. levodopa as initial treatment for Parkinson disease: A randomized controlled trial JAMA 284 1931–1938 Occurrence Handle10.1001/jama.284.15.1931

    Article  Google Scholar 

  • M Stacy A Bowron M Guttman R Hauser K Hughes JP Larsen et al. (2005) ArticleTitleIdentification of motor and nonmotor wearing-off in Parkinson’s disease: Comparison of a patient questionnaire versus a clinician assessment Mov Disord 20 726–733 Occurrence Handle15719426 Occurrence Handle10.1002/mds.20383

    Article  PubMed  Google Scholar 

  • K Thomas J Samanta P Mahant K Williamson M Stacy (2002) ArticleTitleThe Ali Project: A web-based database for Parkinson’s disease Mov Disord 17 IssueID[Suppl 5] S141

    Google Scholar 

  • InstitutionalAuthorNameUPDRS Taskforce (2003) ArticleTitleThe Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations Mov Disord 18 738–750 Occurrence Handle10.1002/mds.10473

    Article  Google Scholar 

  • M Welsh MP McDermott RG Holloway S Plumb R Pfeiffer J Hubble (2003) ArticleTitleDevelopment and testing of the Parkinson’s disease quality of life scale Mov Disord 18 637–645 Occurrence Handle12784266 Occurrence Handle10.1002/mds.10424

    Article  PubMed  Google Scholar 

  • T Witjas E Kaphan JP Azulay O Blin M Ceccaldi J Pouget et al. (2002) ArticleTitleNonmotor fluctuations in Parkinson’s disease: frequent and disabling Neurology 59 408–413 Occurrence Handle12177375

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Duke University Medical Center, Durham, North Carolina, USA

    M. Stacy

  2. University of South Florida College of Medicine, Tampa, Florida, USA

    R. Hauser

Authors
  1. M. Stacy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Hauser
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stacy, M., Hauser, R. Development of a Patient Questionnaire to facilitate recognition of motor and non-motor wearing-off in Parkinson’s disease. J Neural Transm 114, 211–217 (2007). https://doi.org/10.1007/s00702-006-0554-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-006-0554-y

Search

Navigation