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Depressive symptoms in older long-term colorectal cancer survivors: a population-based analysis using the SEER-Medicare healthcare outcomes survey

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Abstract

Purpose

Colorectal cancer survivorship has improved significantly over the last 20 years; however, few studies have evaluated depression among older colorectal cancer survivors, especially using a population-based sample. The aim of this study was to identify correlates for positive depression screen among colorectal cancer survivors who underwent potentially curative surgery.

Methods

Using the 1998–2007 Surveillance, Epidemiology, and End-Result registry and the Medicare Health Outcome Survey linked dataset, we identified patients over 65 with pathology confirmed and resected colorectal cancer enrolled in Medicare. Using univariate and multiple variable analyses, we identified characteristics of patients with and without positive depression screen.

Results

Resected colorectal cancer patients (1785) (median age 77, 50.8 % female) were identified in the dataset with 278 (15.6 %) screening positive for symptoms of depression. Median time from diagnosis to survey was 62 months. On univariate analysis, larger tumor size, advanced cancer stage, and extent of resection were not correlates of depressive symptoms (all p > 0.05). After adjusting for confounders, income less than US$30,000 per year (OR 1.50, 1.02–2.22, 95 % CI, p = 0.042), non-white race (OR 1.51, 1.05–2.17, 95 % CI, p = 0.027), two or more comorbidities (OR 1.78, 1.25–2.52, 95 % CI, p = 0.001), and impairment in activities of daily living (OR 5.28, 3.67–7.60, 95 % CI, p < 0.001) were identified as independent correlates of depressive symptoms in colorectal cancer survivors.

Conclusions

In the current study, socioeconomic status and features of physical health rather than tumor characteristics were associated with symptoms of depression among long-term colorectal cancer survivors.

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Author information

Authors and Affiliations

  1. Department of General Surgery, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA

    Clancy J. Clark, David Hiller & Jaime Bohl

  2. Division of Public Health Sciences, Wake Forest School of Medicine, Salem, Winston, NC, USA

    Nora F. Fino

  3. Wake Forest School of Medicine, Salem, Winston, NC, USA

    Jia Hao Liang

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  1. Clancy J. Clark
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  2. Nora F. Fino
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Correspondence to Clancy J. Clark.

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Clark, C.J., Fino, N.F., Liang, J.H. et al. Depressive symptoms in older long-term colorectal cancer survivors: a population-based analysis using the SEER-Medicare healthcare outcomes survey. Support Care Cancer 24, 3907–3914 (2016). https://doi.org/10.1007/s00520-016-3227-x

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