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Quality of life in patients with muscle invasive and non-muscle invasive bladder cancer

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Abstract

Purpose

Compared to the literature on other malignancies, data on quality of life (QoL) in bladder cancer are sparse. This study sought answers to the following questions: In what QoL domains do patients with bladder cancer differ from the general population? Do patients with radical cystectomy differ in QoL compared to those who received conservative treatment? Do patients with neobladder generally have better QoL compared to patients with other diversion methods?

Methods

At the beginning of inpatient rehabilitation, N = 823 patients with bladder cancer were assessed. Data of a representative community sample (N = 2037) were used for comparison. The questionnaire EORTC QLQ-C30 was used to measure QoL. Multivariate linear regression models were computed to investigate differences between groups.

Results

Patients with both non-muscle invasive and muscle invasive bladder cancer reported significantly more problems and worse functioning than the general population. Radiotherapy is associated with clinically relevant more pain, dyspnoea, constipation, appetite loss and decreased social functioning while chemotherapy is associated more with dyspnoea. Cystectomy patients reported more fatigue, appetite loss and decreased role functioning.

Male patients ≥70 years with conduit experienced more sleep and emotional problems. These effects of urinary diversion were not observed in women and younger patients.

Conclusions

Patients with bladder cancer experience various QoL concerns at the beginning of inpatient rehabilitation. These problems can partly be explained by the type of treatment the patients receive. Type of urinary diversion is relevant for QoL in subgroups of patients.

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Conflict of interest

This research received no external funding. There have been no involvements that might raise the question of bias in the work reported or in the conclusions, implications or opinions stated. The authors have full control of all primary data which can be reviewed by the journal if requested.

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Authors and Affiliations

  1. Institute of Medical Biostatistics, Epidemiology, and Informatics, Division of Epidemiology and Health Services Research, University Medical Centre of Johannes Gutenberg University, Obere Zahlbacher Straße 69, 55131, Mainz, Germany

    S. Singer

  2. Department of Health Psychology, University of Wuppertal, Wuppertal, Germany

    C. Ziegler

  3. Department of Urology, University Hospital Leipzig, Leipzig, Germany

    T. Schwalenberg

  4. Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany

    A. Hinz & H. Götze

  5. Rehabilitation Clinic Bad Oexen, Oexen, Germany

    T. Schulte

  6. Department of Psychosomatic Medicine and Psychotherapy, University Hospital Leipzig, Leipzig, Germany

    S. Singer

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  1. S. Singer
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  2. C. Ziegler
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  3. T. Schwalenberg
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  4. A. Hinz
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Correspondence to S. Singer.

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Singer, S., Ziegler, C., Schwalenberg, T. et al. Quality of life in patients with muscle invasive and non-muscle invasive bladder cancer. Support Care Cancer 21, 1383–1393 (2013). https://doi.org/10.1007/s00520-012-1680-8

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  • DOI: https://doi.org/10.1007/s00520-012-1680-8

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