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Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation

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Abstract

Purpose

Cachexia in patients with hematological malignancies is often related to sarcopenia. We believe that allogeneic hematopoietic stem cell transplant (allo-HSCT) patients often exhibit sarcopenia prior to transplantation. Here, we aimed to investigate the prevalence of sarcopenia and its relationship with body composition, physiological function, nutrition, fatigue, and health-related quality of life (QOL) in patients before allo-HSCT. We further investigated the confounding factors associated with sarcopenia.

Methods

We included 164 patients with allo-HSCT in this study. Body composition, handgrip, knee extensor strength, and 6-min walk test were evaluated. Furthermore, fatigue, nutritional status, and health-related QOL were also evaluated.

Results

Eighty-three patients (50.6 %) enrolled in our study had sarcopenia prior to allo-HSCT. Patients with sarcopenia experienced decreased muscular strength and increased fatigue compared with patients without sarcopenia (p < 0.05). Patients with sarcopenia showed significantly lower scores in physical functioning, bodily pain, and vitality in health-related QOL than those without sarcopenia. Multivariate regression analysis revealed that only gender and body mass index were significantly related to sarcopenia (gender, odds ratio, 3.09; body mass index, odds ratio, 0.70; p < 0.01).

Conclusions

Sarcopenia is common in patients before allo-HSCT and related to low muscle strength, fatigue, and health-related QOL. Male patients may be more susceptible to sarcopenia than female patients before allo-HSCT. Further study of rehabilitation with gender insight is warranted for patients receiving allo-HSCT.

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Acknowledgments

The authors are grateful to the study participants, the physiotherapists at the Rehabilitation Department, and the physicians at the Division of Hematology of Hyogo College of Medicine Hospital. This study was supported in part by a grant-in-aid from the Foundation for the Promotion of Cancer Research.

Conflict of interest

The authors declare no conflict of interest. Furthermore, the authors have full control of all primary data and agree to allow the journal to review their data if requested.

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Authors and Affiliations

  1. Department of Rehabilitation, Hyogo College of Medicine Hospital, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Shinichiro Morishita, Takashi Tanaka & Yusuke Itani

  2. Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Katsuji Kaida, Kazuhiro Ikegame, Masaya Okada, Shinichi Ishii & Hiroyasu Ogawa

  3. Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Norihiko Kodama & Kazuhisa Domen

Authors
  1. Shinichiro Morishita
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  2. Katsuji Kaida
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  3. Takashi Tanaka
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  4. Yusuke Itani
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  5. Kazuhiro Ikegame
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  7. Shinichi Ishii
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  10. Kazuhisa Domen
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Correspondence to Shinichiro Morishita.

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Morishita, S., Kaida, K., Tanaka, T. et al. Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation. Support Care Cancer 20, 3161–3168 (2012). https://doi.org/10.1007/s00520-012-1460-5

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