Skip to main content
Log in

Validity and reliability of the EQ-5D for cancer patients in Korea

  • Original Article
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to assess the validity and reliability of the Korean version of the EQ-5D health questionnaire for use in patients with cancer in Korea.

Methods

Patients with colorectal cancer were recruited from one ambulatory cancer center. Each participant consecutively self-administered the EQ-5D, the EORTC QLQ-C30, and the Short Form-36 (SF-36). Discriminatory ability was evaluated by comparing the SF-36 subscales with their corresponding EQ-5D dimensions. Convergent validity was assessed by examining the correlations between the EQ-5D index, EORTC QLQ-C30 subscales, and SF-36 scale and summary scores. Test-retest reliability was also evaluated.

Results

Subjects reporting problems in each EQ-5D dimension showed lower scores on all SF-36 subscales. As expected, the relationships were stronger between the EQ-5D functional dimensions and physical function on the EORTC QLQ-C30 and between the EQ-5D anxiety/depression dimension and emotional function on the EORTC QLQ-C30. The EQ-5D index and SF-36 scales were moderately or highly correlated. intraclass correlation coefficient of the EQ-5D index was 0.45.

Conclusions

The Korean version of the EQ-5D may be a valid tool for assessing the health-related quality of life of patients with cancer. However, further research is needed to determine the reliability of the Korean EQ-5D over different time intervals and disease conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. The Korea Central Cancer Registry, National Cancer Center (2010) Annual report of cancer statistics in Korea in 2008. Ministry of Health and Welfare

  2. Nayfield SG, Ganz PA, Moinpour CM et al (1992) Report from a National Cancer Institute (USA) workshop on quality of life assessment in cancer clinical trials. Qual Life Res 1(3):203–210

    Article  PubMed  CAS  Google Scholar 

  3. Torrance GW (1986) Measurement of health state utilities for economic appraisal. J Health Econ 5(1):1–30

    Article  PubMed  CAS  Google Scholar 

  4. Cost-effectiveness in health and medicine. In Gold MR, Siegal JE, Russell LB, et al (Eds.) (1996) Oxford University Press. New York

  5. Räsänen P, Roine E, Sintonen H et al (2006) Use of quality-adjusted life years for the estimation of effectiveness of health care: a systematic literature review. Int J Technol Assess Health Care 22(2):235–41

    Article  PubMed  Google Scholar 

  6. Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ C-30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–76

    Article  PubMed  CAS  Google Scholar 

  7. Rowen D, Brazier J, Young T et al (2011) Deriving a preference-based measure for cancer using the EORTC QLQ-C30. Value Health 14(5):721–31

    Article  PubMed  Google Scholar 

  8. (1996) Quality of life and pharmacoeconomics in clinical trials. 2nd edn. In Spilker, B. (Ed.) Lippincott-Raven. Philadelphia

  9. Health Insurance Review and Assessment service (2006) Guidelines for economic evaluation of pharmaceuticals

  10. Kim MH, Cho YS, Uhm WS et al (2005) Cross-cultural adaptation and validation of the Korean version of the EQ-5D in patients with rheumatic diseases. Qual Life Res 14(5):1401–1406

    Article  PubMed  Google Scholar 

  11. Kim SH, Kim HJ, Lee SI, et al. Comparing the psychometric properties of the EQ-5D-3L and EQ-5D-5L in cancer patients in Korea. Qual Life Res. 2011 Sep 23. DOI 10.1007/s11136-011-0018-1

  12. Brooks R, Rabin RE, de Charro F (2003) The measurement and valuation of health status using EQ-5D: a European perspective. Kluwer Academic Publishers, Dordrecht

    Google Scholar 

  13. Yun YH, Park YS, Lee ES et al (2004) Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res 13(4):863–868

    Article  PubMed  CAS  Google Scholar 

  14. Ware JE Jr, Kosinski MB, Bjorner JB et al (2007) User's manual for the SF-36v2® health survey, 2nd edn. Quality Metric Incorporated, Lincoln

    Google Scholar 

  15. Han CW, Lee EJ, Iwaya T et al (2004) Development of the Korean version of short-form 36-item health survey: health related QOL of healthy elderly people and elderly patients in Korea. Tohoku J Exp Med 203(3):189–194

    Article  PubMed  Google Scholar 

  16. McHorney CA, Ware JE Jr, Raczek AE (1993) The MOS 36-item short-form health survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 31(3):247–263

    Article  PubMed  CAS  Google Scholar 

  17. Brazier JE, Harper R, Jones NM et al (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 305(6846):160–164

    Article  PubMed  CAS  Google Scholar 

  18. McHorney CA, Ware JE Jr, Lu JF et al (1994) The MOS 36-item short-form health survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care 32(1):40–66

    Article  PubMed  CAS  Google Scholar 

  19. Lee YK, Nam HS, Chuang LH et al (2009) South Korean time trade-off values for EQ-5D health states: modeling with observed values for 101 health states. Value Health 12(8):1187–1193

    Article  PubMed  Google Scholar 

  20. Brazier J, Roberts J, Deverill M (2002) The estimation of a preference-based measure of health from the SF-36. J Health Econ 21(2):271–292

    Article  PubMed  Google Scholar 

  21. Brazier J, Jones N, Kind P (1993) Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire. Qual Life Res 2(3):169–180

    Article  PubMed  CAS  Google Scholar 

  22. Kontodimopoulos N, Pappa E, Niakas D et al (2008) Validity of the EuroQoL (EQ-5D) instrument in a Greek general population. Value Health 11(7):1162–1169

    Article  PubMed  Google Scholar 

  23. Chang TJ, Tarn YH, Hsieh CL et al (2007) Taiwanese version of the EQ-5D: validation in a representative sample of the Taiwanese population. J Formos Med Assoc 106(12):1023–1031

    Article  PubMed  Google Scholar 

  24. Johnson JA, Coons SJ (1998) Comparison of the EQ-5D and SF-12 in an adult US sample. Qual Life Res 7(2):155–166

    Article  PubMed  CAS  Google Scholar 

  25. Johnson JA, Pickard AS (2000) Comparison of the EQ-5D and SF-12 health surveys in a general population survey in Alberta, Canada. Med Care 38(1):115–121

    Article  PubMed  CAS  Google Scholar 

  26. Lang HC, Chuang L, Shun SC et al (2010) Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 18(10):1279–1286

    Article  PubMed  Google Scholar 

  27. Fleiss JL (1981) Statistical methods for rates and proportions, 2nd edn. Wiley, New York

    Google Scholar 

  28. Hripcsak G, Heitjan DF (2002) Measuring agreement in medical informatics reliability studies. J Biomed Inform 35(2):99–110

    Article  PubMed  Google Scholar 

  29. Hurst NP, Kind P, Ruta D et al (1997) Measuring health-related quality of life in rheumatoid arthritis: validity, responsiveness and reliability of EuroQol (EQ-5D). Br J Rheumatol 36(5):551–559

    Article  PubMed  CAS  Google Scholar 

Download references

Disclosures

None

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Min-Woo Jo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, S.H., Hwang, J.S., Kim, T.W. et al. Validity and reliability of the EQ-5D for cancer patients in Korea. Support Care Cancer 20, 3155–3160 (2012). https://doi.org/10.1007/s00520-012-1457-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-012-1457-0

Keywords

Navigation