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The cognitive effects of opioids in cancer: a systematic review

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Abstract

Objective and methods

In order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design, the level of evidence, and opioid regimen.

Result

Six studies reported association between poor cognitive performance (reaction time, attention, balance, and memory) and opioid use.

Conclusion

These cognitive deficits were captured with neuropsychological tests; however, their clinical relevance is still uncertain.

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Authors and Affiliations

  1. Multidisciplinary Pain Centre, Dept. 7612, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark

    Geana Paula Kurita & Per Sjøgren

  2. Palliative Team Service, Herning Hospital, Gl. Landevej 61, 7400, Herning, Denmark

    Lena Lundorff

  3. Department of Medical Surgical Nursing, School of Nursing, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar n 419, CEP 05403-000, São Paulo, SP, Brazil

    Cibele Andrucioli de Mattos Pimenta

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  1. Geana Paula Kurita
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  2. Lena Lundorff
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  3. Cibele Andrucioli de Mattos Pimenta
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  4. Per Sjøgren
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Correspondence to Geana Paula Kurita.

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Kurita, G.P., Lundorff, L., Pimenta, C.A.d. et al. The cognitive effects of opioids in cancer: a systematic review. Support Care Cancer 17, 11–21 (2009). https://doi.org/10.1007/s00520-008-0497-y

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  • DOI: https://doi.org/10.1007/s00520-008-0497-y

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