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Changes in quality of life and its related factors in liver cancer patients receiving stereotactic radiation therapy

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Abstract

Purpose

Due to the increasing use of stereotactic radiotherapy (SRT) in treating advanced liver cancer patients, the purpose of this longitudinal study was to explore the changes and factors related to quality of life (QOL) in patients receiving SRT treatment.

Materials and methods

Liver cancer patients receiving SRT in northern Taiwan were recruited. The patients were followed up during the baseline pre-SRT and the first 6 weeks of SRT (T0 to T6) in assessing functional status and symptom severity, while depression, selected laboratory data, and QOL were assessed every 3 weeks (T0, T3, and T6). Generalized estimating equations (GEE) analysis was used to explore the significant factors related to the change in QOL.

Results

Ninety-nine patients with advanced liver cancer completed seven interviews. The results showed that QOL during SRT was moderate and relatively stable. Performance functional status, depression, the level of albumin, and overall symptom severity were significantly associated with changes in QOL. A further analysis of the relationships between individual symptom severity and QOL revealed that fatigue, lack of appetite, pain, and nausea were the symptoms most affecting QOL across the 6 weeks of SRT.

Conclusion

Liver cancer patients had stable and moderate levels of QOL during SRT. Factors related to QOL across the 6 weeks were multi-dimensional. Both overall symptom severity and selected individual symptoms were important to patients' QOL. These factors should all be carefully assessed and clinically treated to enhance liver cancer patients' QOL during SRT.

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Acknowledgments

This study was partially supported by a grant from the National Science Council in Taiwan. The authors gratefully acknowledge the assistance of the patients who participated in this study. The authors also thank George Plautz for his editing.

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Authors and Affiliations

  1. Department of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan

    Shiow-Ching Shun, Yeur-Hur Lai & Po-Jui Yu

  2. Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan

    Jeng-Fong Chiou

  3. College of Nursing, Cardinal Tien College of Nursing, Taipei, Taiwan

    Lin-Lin Wei

  4. Department of Radiation Oncology, Wanfang Hospital, Taipei, Taiwan

    Jo-Ting Tsai

  5. Department of Radiation Oncology, Min-Sheng General Hospital, Ching-Kuo Campus, Taoyuan, Taiwan

    Chung-Yu Kao

  6. Department of Nursing, Fooyin University, Kaohsiung, Taiwan

    Ya-Li Hsiao

  7. No. 1, Jen-Ai Rd. Sec. 1, Taipei, 100, Taiwan

    Yeur-Hur Lai

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  1. Shiow-Ching Shun
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  2. Jeng-Fong Chiou
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  3. Yeur-Hur Lai
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  4. Po-Jui Yu
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  5. Lin-Lin Wei
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  8. Ya-Li Hsiao
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Correspondence to Yeur-Hur Lai.

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Shun, SC., Chiou, JF., Lai, YH. et al. Changes in quality of life and its related factors in liver cancer patients receiving stereotactic radiation therapy. Support Care Cancer 16, 1059–1065 (2008). https://doi.org/10.1007/s00520-007-0384-y

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  • DOI: https://doi.org/10.1007/s00520-007-0384-y

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