Skip to main content
Log in

Exercise in the prevention and rehabilitation of breast cancer


  • Published:
Wiener klinische Wochenschrift Aims and scope Submit manuscript

Summary

Breast cancer is the most common type of cancer among women worldwide. Several epidemiological studies have shown an inverse relationship between the risk of breast cancer and physical activity levels, whereas exercise training has been recognized as a significant means in the rehabilitation process of breast cancer survivors. The relative risk reduction of breast cancer for women who engaged in moderate to vigorous physical activity for 3–5 days peek week ranged between 20–40 %. Furthermore, several studies demonstrated a 24–67 % reduction in the risk of total deaths and 50–53 % reduction in the risk of breast cancer deaths in women who are physically active after breast cancer diagnosis compared with sedentary women. Breast cancer survivors should be encouraged to participate in rehabilitation programs in order to obtain numerous physiological and psychological benefits. These include reductions in fatigue and improvements in immune function, physical functioning, body composition, and quality of life. Based on recent scientific evidence, a complete rehabilitation program for patients with breast cancer should combine both strength and aerobic exercise in order to maximize the expected benefits.

Zusammenfassung

Brustkrebs ist weltweit die häufigste Krebserkrankung von Frauen. Verschiedene epidemiologische Studien haben eine inverse Korrelation zwischen dem Risiko an Brustkrebs zu erkranken und physischer Aktivität gezeigt. Körperliches Training wurde auch als ein signifikantes Mittel im Rehabilitationsprozess von Brustkrebs Überlebenden anerkannt.

Die Reduktion des relativen Risikos von Brustkrebs betrug bei Frauen, die moderates bis anstrengendes Training 3– bis maximal 5-Mal pro Woche betrieben zwischen 20 und 40 %. Außerdem zeigten einige Studien eine 24–67 %ige Reduktion der Gesamtmortalität, beziehungsweise eine 50–53 %ige Reduktion des Risikos an Brustkrebs zu versterben bei physisch aktiven, an Brustkrebs erkrankten Frauen im Vergleich zu jenen, die keine physische Aktivität betrieben.

Brustkrebs Überlebende sollten motiviert werden, an Rehabilitationsprogrammen teilzunehmen, um von zahlreichen physischen und psychologischen Vorteilen zu profitieren. Diese Vorteile inkludieren eine Abnahme der Müdigkeit, sowie eine Besserung der Funktion des Immunsystems, des körperlichen Wohlbefindens und der Lebensqualität. Entsprechend rezenter wissenschaftlicher Evidenz sollte ein komplettes Rehabilitationsprogramm für Patienten mit Brustkrebs zur Maximierung des erwarteten Vorteils sowohl Kraft-Übungen als auch aerobe Übungen beinhalten.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. www.who.int

  2. www.cancer.org

  3. Dimeo FC, Stieglitz RD, Novelli-Fischer U, Fetscher S, Keul J. Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer. 1999;85(10):2273–7.

    Article  CAS  PubMed  Google Scholar 

  4. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer. 2008;8(3):205–11.

    Article  CAS  PubMed  Google Scholar 

  5. McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell LL, Woods N, Ockene J. Recreational physical activity and the risk of breast cancer in postmenopausal women. The women’s health initiative cohort study. JAMA. 2003;290(10):1331–6.

    Article  CAS  PubMed  Google Scholar 

  6. Dallal CM, Sullivan-Halley J, Ross RK, Wang Y, Deapen D, Horn-Ross PL, Reynolds P, Stram DO, Clarke CA, Anton-Culver H, Ziogas A, Peel D, West DW, Wright W, Bernstein L. Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers study. Arch Intern Med. 2007;167(4):408–15.

    Article  PubMed  Google Scholar 

  7. Friedenreich CM, Cust AE. Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med. 2008;42(8):636–47.

    Article  CAS  PubMed  Google Scholar 

  8. Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC. Physical activity and risk of breast cancer among postmenompausal women. Arch Intern Med. 2010;170(19):1758–64.

    Google Scholar 

  9. Pronk A, Shu XO, Ji BT, Chow WH, Xue S, Yang G, Li HL, Rothman N, Gao YT, Zheng W, Matthews CE. Physical activity and breast cancer risk in Chinese women. Br J Cancer. 2011;106(9):1443–50.

    Article  Google Scholar 

  10. Friedenreich CM, Neilson HK, Lynch BM. State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer. 2010;46(14):2593–604.

    Article  PubMed  Google Scholar 

  11. Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard-Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer. 2003;97(7):1746–57.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity and lifestyle study. J Clin Oncol. 2008;26(24):3958–64.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Physical activity levels among breast cancer survivors. Med Sci Sports Exerc. 2004;36(9):1484–91.

    PubMed Central  PubMed  Google Scholar 

  14. Fairey AS, Courneya KS, Field CJ, Mackey JR. Physical exercise and immune system function in cancer survivors. Cancer. 2002;94(2):539–51.

    Article  PubMed  Google Scholar 

  15. Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. J Clin Oncol. 2003;21(9):1660–8.

    Article  PubMed  Google Scholar 

  16. Jones L, Demark-Wahnfried D. Diet, exercise and complementary therapies after primary treatment for cancer. Lancet Oncol. 2006;7(12):1017–26.

    Article  PubMed  Google Scholar 

  17. Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479–86.

    Article  CAS  PubMed  Google Scholar 

  18. Holick C, Newcomb P, Trentham-Dietz A, Titus-Ernstoff L, Bersch AJ, Stampfer MJ, Baron JA, Egan KM, Willett WC. Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17(2):379–86.

    Article  PubMed  Google Scholar 

  19. Friedenreich CM, Gregory J, Kopciuk KA, Mackey JR, Courneya KS. Prospective cohort study of lifetime physical activity and breast cancer survival. Int J Cancer. 2009;124(8):1954–62.

    Article  CAS  PubMed  Google Scholar 

  20. Peel JB, Sui X, Adams SA, Hebert JR, Hardin JW, Blair SN. A prospective study of cardiorespiratory fitness and breast cancer mortality. Med Sci Sports Exerc. 2009;41(4):742–8.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR. Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. J Appl Physiol. 2005;98(4):1534–40.

    Article  PubMed  Google Scholar 

  22. Ligibel JA, Campbell N, Partridge A, Chen WY, Salinardi T, Chen H, Adloff K, Keshaviah A, Winer EP. Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. J Clin Oncol. 2008;26(6):907–12.

    Article  CAS  PubMed  Google Scholar 

  23. Lira FS, Rosa JC, Yamashita AS, Koyama CH, Batista ML Jr, Seelaender M. Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise. Cell Biochem Funct. 2009;27:71–5.

    Article  CAS  PubMed  Google Scholar 

  24. Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N, Flesch-Janys D, Chang-Claude J. Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3402–10.

    Article  PubMed  Google Scholar 

  25. Neilson HK, Friedenreich CM, Brockton NT, Millikan RC. Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev. 2009;18(1):11–27.

    Article  CAS  PubMed  Google Scholar 

  26. Zielinski MR, Muenchow M, Wallig MA, Horn PL, Woods JA. Exercise delays allogeneic tumor growth and reduces intratumoral inflammation and vascularization. J Appl Physiol. 2004;96(6):2249–56.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Jones LW, Viglianti BJ, Tashjian JA, Kothadia SM, Keir ST, Freedland SJ, Potter MQ, Moon EJ, Schroeder T, Herndon JE, Dewhirst MW. Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. J Appl Physiol. 2010;108(2):343–8.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Harris SR, Niesen-Vertommen SL. Challenging the myth of exercise-induced lymphedema following breast cancer: a series of case reports. J Surg Oncol. 2000;74(2):95–8.

    Article  CAS  PubMed  Google Scholar 

  29. McKenzie DC, Kalda AL. The effect of upper extremity exercise on secondary lymphedema in breast cancer patients: a pilot study. J Clin Oncol. 2003;21(3):463–6.

    Article  PubMed  Google Scholar 

  30. Hayes SC, Reul-Hirche H, Turner J. Exercise and secondary lymphedema: safety, potential benefits and research issues. Med Sci Sports Exerc. 2009;41(3):483–9.

    Article  PubMed  Google Scholar 

  31. Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Lewis-Grant L, Bryan CJ, Williams-Smith CT, Greene QP. Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med. 2009;361(7):664–73.

    Article  CAS  PubMed  Google Scholar 

  32. Schmitz KH, Ahmed RL, Troxel AB, Cheville A, Lewis-Grant L, Smith R, Bryan CJ, Williams-Smith CT, Chittams J. Weight lifting for women at risk for breast cancer related lymphedema. JAMA. 2010;304(24):2699–705.

    Article  CAS  PubMed  Google Scholar 

  33. Ohira T, Schmitz KH, Ahmed RL, Yee D. Effects of weight training on quality of life in recent breast cancer survivors: the weight training for breast cancer survivors (WTBS) study. Cancer. 2006;106(9):2076–83.

    Article  PubMed  Google Scholar 

  34. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, Ladha AB, Proulx C, Vallance J, Lane K, Yasui Y, McKenzie D. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol. 2007;25:4396–404.

    Article  PubMed  Google Scholar 

  35. De Backer IC, Vreugdenhil G, Nijziel MR, Kester AD, van Breda E, Schep G. Long-term follow-up after cancer rehabilitation using high-intensity resistance training: persistent improvement of physical performance and quality of life. Br J Cancer. 2008;99(1):30–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. DeBacker IC, Schep G, Backx FJ, Vreugdenhil G, Kuipers H. Resistance training in cancer survivors: a systematic review. Int J Sports Med. 2009;30(10):703–12.

    Article  CAS  Google Scholar 

  37. Courneya KS, Mackey JR, McKenzie DC. Exercise for breast cancer survivors: research evidence and clinical guidelines. Phys Sportsmed. 2002;30(8):33–42.

    Article  PubMed  Google Scholar 

  38. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL. American College of Sports Medicine. Roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409–26.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that there are no actual or potential conflicts of interest in relation to this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Konstantinos A Volaklis PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Volaklis, K., Halle, M. & Tokmakidis, S. Exercise in the prevention and rehabilitation of breast cancer
. Wien Klin Wochenschr 125, 297–301 (2013). https://doi.org/10.1007/s00508-013-0365-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00508-013-0365-8

Keywords

Schlüsselwörter

Navigation