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Quality of life of adolescents with end-stage renal disease and kidney transplant

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Abstract

The health-related quality of life (HRQOL) of adolescents with end-stage renal disease (ESRD) is an important marker of disease burden. Our aims were to investigate HRQOL in a group of children and adolescents with ESRD and to compare them with the reference population norms. Ours was a cross-sectional study of 81 patients aged 10 years to 21 years with ESRD (68 with kidney transplants and 13 on dialysis) at five Spanish paediatric nephrology centres. HRQOL was investigated with the Spanish version of the child health and illness profile, adolescent edition (CHIP-AE). Clinical variables such as underlying diagnosis, number of rejection episodes, pre-emptive transplantation, anaemia and height were also analysed. No differences were found between patients with kidney transplants and their healthy peers in any domain or sub-domain of CHIP-AE. The group on dialysis scored lower than healthy controls and patients with transplants for satisfaction with health. Discomfort was higher in patients with transplants who had suffered one rejection episode. Physical discomfort was increased in anaemic patients with transplants. Short patients scored less in the satisfaction domain, with lower self-esteem and lower satisfaction with health. Adolescents with kidney transplants had better satisfaction with health than the group on dialysis, which matched the level of a healthy population. Further long-term prospective research is warranted.

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Acknowledgements

The authors acknowledge Pilar Mosterio, Olga Somoano, Juana Garcia Peliz and Benito Amil for their assistance in the previous pilot study in Asturias; Victoria Serrá for assistance in the scoring and analysis of CHIP-AE data with reference population values; Jose Manuel Fernandez-Carreira and Blanca Mendez for statistical support; and Jorge Baluarte and Nataliya Zelikovsky for critical revision of the manuscript. The previous pilot study developed in Asturias was supported by the Ernesto Sánchez-Villares Foundation Grant (1999).

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Authors and Affiliations

  1. Division of Paediatrics, Hospital San Agustín, Avilés, Spain

    Isolina Riaño-Galán

  2. Division of Paediatric Nephrology, Hospital Universitario Central de Asturias, 33006, Oviedo, Spain

    Serafín Málaga

  3. Agència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM), Institut Municipal d’Investigació Mèdica (IMIM) and CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain

    Luis Rajmil

  4. Division of Paediatric Nephrology, Hospital Clínico de Santiago, Santiago de Compostela, Spain

    Gema Ariceta

  5. Division of Paediatric Nephrology, Hospital Universitario Infantil La Paz, Madrid, Spain

    Mercedes Navarro

  6. Division of Paediatric Nephrology, Hospital Miguel Servet, Zaragoza, Spain

    Cesar Loris

  7. Division of Paediatric Nephrology, Hospital Cruces, Bilbao, Spain

    Alfredo Vallo

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  1. Isolina Riaño-Galán
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  2. Serafín Málaga
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  3. Luis Rajmil
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  4. Gema Ariceta
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  5. Mercedes Navarro
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  6. Cesar Loris
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  7. Alfredo Vallo
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Corresponding author

Correspondence to Serafín Málaga.

Additional information

The work was carried out at the Divisions of Paediatric Nephrology of the following hospitals in Spain: Central de Asturias (Oviedo), Clínico de Santiago, Infantil La Paz (Madrid), Miguel Servet (Zaragoza) and Cruces (Bilbao)

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Riaño-Galán, I., Málaga, S., Rajmil, L. et al. Quality of life of adolescents with end-stage renal disease and kidney transplant. Pediatr Nephrol 24, 1561–1568 (2009). https://doi.org/10.1007/s00467-009-1175-0

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  • DOI: https://doi.org/10.1007/s00467-009-1175-0

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