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Arterial versus venous endothelial cells

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Abstract

Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect the arterial and venous systems. Because these two major conducting systems of the cardiovasculature differ functionally, it is not surprising that the physical makeup of arteries and veins, including the ECs that line their lumina, are also distinct. Although few would argue that the local environment contributes to the differences between arteries and veins, recent evidence has shown that the specification of arterial and venous identity is largely genetically determined.

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Acknowledgements

We thank Mr. Peter Mallen for the artwork, Dr. Eric Finkelstein for Fig. 2, and Ms. Christine Bagley for her editorial assistance.

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Authors and Affiliations

  1. Schepens Eye Research Institute and Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA

    Nathaniel G. dela Paz & Patricia A. D’Amore

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  1. Nathaniel G. dela Paz
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  2. Patricia A. D’Amore
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Correspondence to Nathaniel G. dela Paz.

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The authors are supported by NIH EY05318 and EY015435 (P.A.D.). Dr. dela Paz is supported by NRSA Institutional Research Training Grant T32 HL076115. Dr. D’Amore is a Research to Prevent Blindness Senior Scientific Investigator.

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dela Paz, N.G., D’Amore, P.A. Arterial versus venous endothelial cells. Cell Tissue Res 335, 5–16 (2009). https://doi.org/10.1007/s00441-008-0706-5

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