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Linking morphological and functional variability in hand movement and silent reading

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Abstract

It is generally accepted in neuroscience that anatomy and function go hand in hand. Accordingly, a local morphological variability could lead to a corresponding functional variability. In this study, we tested this hypothesis by linking the variability of the cortical folding pattern of 252 right-handed subjects to the localization or the pattern of functional activations induced by hand motion or silent reading. Three regions are selected: the central sulcus, the precentral sulcus and the superior temporal sulcus (STS). “Essential morphological variability traits” are identified using a method building upon multidimensional scaling. The link between variability in anatomy and function is confirmed by the perfect match between the central sulcus morphological “hand knob” and the corresponding motor activation: as the location of the hand knob moves more or less dorsally along the central sulcus, the motor hand activation moves accordingly. Furthermore, the size of the left hand activation in the right hemisphere is correlated with the knob location in the central sulcus. A new link between functional and morphological variability is discovered relative to the location of a premotor activation induced by silent reading. While this reading activation is located next to the wall of the central sulcus when the hand knob has a ventral positioning, it is pushed into a deep gyrus interrupting the precentral sulcus when the knob is more dorsal. Finally, it is shown that the size of the reading activation along the STS is larger when the posterior branches are less developed.

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Acknowledgments

This work is partially funded by the French National Agency for Research (ANR-09-BLAN-0038-01 ‘BRAINMORPH’, ANR-12-JS03-001-01 ‘MODEGY’, ANR-14-CE30-0014 ‘APEX’) and the European FET Flagship project ‘Human Brain Project’ (SP2).

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Authors and Affiliations

  1. UNATI, NeuroSpin, I2BM, CEA, Gif-sur-Yvette, France

    Z. Y. Sun, D. Rivière & J.-F. Mangin

  2. CATI Multicenter Neuroimaging Platform http://cati-neuroimaging.com

    Z. Y. Sun, D. Rivière & J.-F. Mangin

  3. Collège de France, Paris, France

    S. Dehaene

  4. INSERM U992, CEA, DSV/I2BM, NeuroSpin Center, Cognitive Neuroimaging Unit, University of Paris-Sud, 91191, Gif-sur-Yvette, France

    P. Pinel, A. Moreno & S. Dehaene

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  1. Z. Y. Sun
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  2. P. Pinel
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  3. D. Rivière
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  4. A. Moreno
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  5. S. Dehaene
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Correspondence to J.-F. Mangin.

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Sun, Z.Y., Pinel, P., Rivière, D. et al. Linking morphological and functional variability in hand movement and silent reading. Brain Struct Funct 221, 3361–3371 (2016). https://doi.org/10.1007/s00429-015-1106-8

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  • DOI: https://doi.org/10.1007/s00429-015-1106-8

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