Skip to main content

Advertisement

SpringerLink
Log in

Social and clinical determinants of quality of life in Parkinson’s disease in Austria: a cohort study

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Parkinson’s disease (PD) is associated with a reduction of health-related quality of life (HrQoL). Demographic and clinical determinants of HrQoL in PD have been previously investigated, but less is known about its social determinants. Data on HrQoL in Austrian patients with PD are not available. The objective of this cross-sectional survey was to evaluate HrQoL of Austrian patients with PD and to provide a comprehensive analysis of its social and clinical determinants. Outpatients (n = 100) with idiopathic PD were recruited in the Department of Neurology of the University Innsbruck. Clinical status was estimated using the Unified Parkison’s Disease Rating Scale (UPDRS). HrQoL was evaluated using a generic instrument, the EuroQol (EQ5D and EQ-VAS). Independent determinants of HrQoL were assessed in multivariate regression analysis. The proportion of PD patients with moderate or severe problems in at least one dimension of the EQ5D was significantly higher than in the general population (90.1 vs. 35.1%, P < 0.001). The mean EQ-VAS score in PD was lower than in the general population (48.9 ± 19.6 vs. 77.0 ± 20.8, P < 0.001). Social support (number of household members) was identified as an independent social determinant of HrQoL. Demographic and clinical determinants were age, depression, UPDRS and motor fluctuations. The analysis of determinants of HrQoL showed that a greater attention should be paid to social support and home care. Our data on HrQoL in PD should be considered in the development of new health care programs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Andlin-Sobocki P, Jonsson B, Wittchen HU, Olesen J (2005) Costs of disorders of the brain in Europe. Eur J Neurol 12(suppl 1):1–27

    Article  PubMed  Google Scholar 

  2. Brazier J, Jones N, Kind P (1993) Testing the validity of the EuroQoL and comparing it with the SF-36 health survey questionnaire. Qual Life Res 2:169–180

    Article  CAS  PubMed  Google Scholar 

  3. Carod-Artal FJ, Vargas AP, Martinez-Martin P (2007) Determinants of quality of life in Brazilian patients with Parkinson’s disease. Mov Disord 22:1408–1415

    Article  PubMed  Google Scholar 

  4. Chapuis S, Ouchchane L, Metz O, Gerbaud L, Durif F (2005) Impact of the motor complications of Parkinson’s disease on the quality of life. Mov Disord 20:224–230

    Article  PubMed  Google Scholar 

  5. Ebrahim S (1995) Clinical and public health perspectives and applications of health-related quality of life measurement. Soc Sci Med 41:1383–1394

    Article  CAS  PubMed  Google Scholar 

  6. Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198

    Article  CAS  PubMed  Google Scholar 

  7. Forsaa EB, Larsen JP, Wentzel-Larsen T, Herlofson K, Alves G (2008) Predictors and course of health-related quality of life in Parkinson’s disease. Mov Disord 23:1420–1427

    Article  PubMed  Google Scholar 

  8. Gibb WRG (1988) Accuracy in the clinical diagnosis of parkinsonian syndromes. Postgrad Med J 64:345–512

    Article  CAS  PubMed  Google Scholar 

  9. Gomez-Esteban JC, Zarranz JJ, Lezcano E, Tijero B, Luna A, Velasco F, Rouco I, Garamendi I (2007) Influence of motor symptoms upon the quality of life of patients with Parkinson’s disease. Eur Neurol 57:161–165

    Article  CAS  PubMed  Google Scholar 

  10. Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J, Buxton M, Dolan P, Kind P, Krabbe P, Ohinmaa A, Parkin D, Roset M, Sintonen H, Tsuchiya A, de Charro F (2003) A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ 4:222–231

    Article  PubMed  Google Scholar 

  11. Harrell FE (2001) Regression modeling strategies. Springer, New York

    Google Scholar 

  12. Hobson P, Holden A, Meara J (1999) Measuring the impact of Parkinson’s disease with the Parkinson’s disease quality of life questionnaire. Age Ageing 28:341–346

    Article  CAS  PubMed  Google Scholar 

  13. Karlsen KH, Larsen JP, Tandberg E, Maeland JG (1999) Influence of clinical and demographic variables on quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 66:431–435

    Article  CAS  PubMed  Google Scholar 

  14. Klepac N, Pikija S, Kraljic T, Relja M, Trkulja V, Juren S, Pavlicek I, Babic T (2007) Association of rural life setting and poorer quality of life in Parkinson’s disease patients: a cross-sectional study in Croatia. Eur J Neurol 14:194–198

    Article  CAS  PubMed  Google Scholar 

  15. Konig HH, Bernert S, Angermeyer MC, Matschinger H, Martinez M, Vilagut G, Haro JM, de Girolamo G, de Graaf R, Kovess V, Alonso J (2009) Comparison of population health status in six European countries: results of a representative survey using the EQ-5D questionnaire. Med Care 47:255–261

    Article  PubMed  Google Scholar 

  16. Kuopio AM, Marttila RJ, Helenius H, Toivonen M, Rinne UK (2000) The quality of life in Parkinson’s disease. Mov Disord 15:216–223

    Article  CAS  PubMed  Google Scholar 

  17. Lindgren P, von Campenhausen S, Spottke AE, Siebert U, Dodel R (2005) Cost of Parkinson’s disease in Europe. Eur J Neurol 12(suppl 1):68–73

    Article  PubMed  Google Scholar 

  18. Marras C, McDermott M, Rochon P, Tanner C, Naglie G, Lang A, Patrkinson Study Group DATATOP Investigators (2008) Predictors of deterioration in health-related quality of life in Parkinson’s disease: results from the DATATOP trial. Mov Disord 23:653–659

    Article  PubMed  Google Scholar 

  19. Martinez-Martin P, Gil-Nagel A, Gracia LM, Gomez JB, Martinez-Sarries J, Bermejo F (1994) Unified Parkinson’s disease rating scale characteristics and structure. The Cooperative Multicentric Group. Mov Disord 9:76–83

    Article  CAS  PubMed  Google Scholar 

  20. Pechevis M, Clarke CE, Vieregge P, Khoshnood B, Deschaseaux-Voinet C, Berdeaux G, Ziegler M (2005) Effects of dyskinesias in Parkinson’s disease on quality of life and health-related costs: a prospective European study. Eur J Neurol 12:956–963

    Article  CAS  PubMed  Google Scholar 

  21. Peto V, Jenkinson C, Fitzpatrick R, Greenhall R (1995) The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res 4:241–248

    Article  CAS  PubMed  Google Scholar 

  22. Rahman S, Griffin HJ, Quinn NP, Jahanshahi M (2008) Quality of life in Parkinson’s disease: the relative importance of the symptoms. Mov Disord 23:1428–1434

    Article  PubMed  Google Scholar 

  23. Reuther M, Spottke EA, Klotsche J, Riedel O, Peter H, Berger K, Athen O, Köhne-Volland R, Dodel RC (2007) Assessing health-related quality of life in patients with Parkinson’s disease in a prospective longitudinal study. Parkinsonism Relat Disord 13:108–114

    Article  CAS  PubMed  Google Scholar 

  24. Sautter J, Wick R, Adlkofer F, Baker MG (2003) Research in the European Union. Lancet Neurol 2:702–706

    Article  PubMed  Google Scholar 

  25. Scaravilli T, Gasparoli E, Rinaldi F, Polesello G, Bracco F (2003) Health-related quality of life and sleep disorders in Parkinson’s disease. Neurol Sci 24:209–210

    Article  CAS  PubMed  Google Scholar 

  26. Schrag A, Jahanshahi M, Quinn N (2000) How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population. Mov Disord 15:1112–1118

    Article  CAS  PubMed  Google Scholar 

  27. Schrag A, Jahanshahi M, Quinn N (2000) What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry 69:308–312

    Article  CAS  PubMed  Google Scholar 

  28. Schrag A, Selai C, Jahanshani M, Quinn N (2000) The EQ-5D—a generic quality of life measure—is a useful instrument to measure quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 69:67–73

    Article  CAS  PubMed  Google Scholar 

  29. Statistik Austria Statistisches Jahrbuch (2009) http://www.statistik.at/web_de/services/stat_jahrbuch/index.html. Accessed 20 December 2008

  30. Group TheEuroQol (1990) EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 16:199–208

    Article  Google Scholar 

  31. The Global Parkinson’s Disease Survey (GPDS) Steering Committee (2002) Factors impacting on quality of life in Parkinson’s disease: results from an international survey. Mov Disord 17:60–67

    Article  Google Scholar 

  32. Visser M, van Rooden SM, Verbaan D, Marinus J, Stiggelbout AM, van Hilten JJ (2008) A comprehensive model of health-related quality of life in Parkinson’s disease. J Neurol 255:1580–1587

    Article  CAS  PubMed  Google Scholar 

  33. Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483

    Article  PubMed  Google Scholar 

  34. Welsh M, McDermott MP, Holloway RG, Plumb S, Pfeiffer R, Hubble J (2003) Development and testing of the Parkinson’s disease quality of life scale. Mov Disord 18:637–645

    Article  PubMed  Google Scholar 

  35. Winter Y, von Campenhausen S, Brozova H, Skoupa J, Reese JP, Botzel K, Eggert K, Oertel WH, Dodel R, Ruzicka E (2009) Costs of illness of Parkinson’s disease in Eastern Europe: a Czech cohort study. Parkinsonism Relat Disord [Epub ahead of print]

  36. Winter Y, von Campenhausen S, Popov G, Reese JP, Klotsche J, Botzel K, Gusev E, Oertel WH, Dodel R, Guekht A (2009) Costs of Illness in a Russian Cohort of Patients with Parkinson’s Disease. PharmacoEconomics 27:571–584

    Article  PubMed  Google Scholar 

  37. World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. World Health Organization, Geneva

    Google Scholar 

  38. Zach M, Friedman A, Slawek J, Derejko M (2004) Quality of life in Polish patients with long-lasting Parkinson’s disease. Mov Disord 19:667–672

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant of the European Commission (QLRT-2001-000 20) and the German Ministry of Education and Research (Competence network Parkinson syndromes; Nr.: 01GI9901/1). The authors’ work was independent of the funder.

Conflict of interest statement

All authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Neurology, Philipps-University Marburg, Rudolf-Bultmannstr. 8, 35039, Marburg, Germany

    Yaroslav Winter, Jens-P. Reese, Wolfgang H. Oertel & Richard Dodel

  2. Department of Neurology, Ludwig-Maximilians-University, Munich, Germany

    Sonja von Campenhausen & Kai Bötzel

  3. Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

    Julia Gasser, Klaus Seppi & Werner Poewe

  4. Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria

    Karl-P. Pfeiffer

Authors
  1. Yaroslav Winter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sonja von Campenhausen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Julia Gasser
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Klaus Seppi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jens-P. Reese
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Karl-P. Pfeiffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kai Bötzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wolfgang H. Oertel
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Richard Dodel
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Werner Poewe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard Dodel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Winter, Y., von Campenhausen, S., Gasser, J. et al. Social and clinical determinants of quality of life in Parkinson’s disease in Austria: a cohort study. J Neurol 257, 638–645 (2010). https://doi.org/10.1007/s00415-009-5389-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-009-5389-7

Keywords

Search

Navigation