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Synergistic effect of chronic pain and nonsuicidal self-harm on pain sensitivity

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Abstract

Abnormalities in pain processing have been observed in patients with chronic pain conditions and in individuals who engage in self-harm, specifically nonsuicidal self-injurious behaviors (NSSI). Both increased and decreased pain sensitivity have been described in chronic pain patients, while decreased pain sensitivity is consistently observed in individuals with NSSI. The objective of the study was to identify the differential effects of chronic pain and NSSI on experimental pain sensitivity, specifically pressure pain threshold, in depressed patients. Moreover, the role that hopelessness may play between depression severity and pain sensitivity was also examined. Depressed patients with and without chronic pain, and with and without lifetime self-harm behaviors were analyzed into four groups. Group 1 (N = 42) included depressed patients with both Chronic pain ( +) and Self-harm ( +), Group 2 (N = 53) included depressed patients with Chronic pain ( +) but no Self-harm (−), Group 3 (N = 64) included depressed patients without Chronic pain (−), but Self-harm ( +), and Group 4 (N = 81) included depressed patients with neither Chronic pain (−) nor Self-harm (−). Healthy controls (N = 45) were also recruited from the community. Depressed patients with both Chronic pain ( +) and Self-harm ( +) reported higher pressure pain threshold measures when compared with the other groups. Mediation analysis indicated that hopelessness mediates the relationship between depression severity and pressure pain threshold. Our findings suggest that a multiprong approach including adequate mental health services and pain control for depressed patients with comorbid chronic pain and nonsuicidal self-harm is needed to yield effective outcomes.

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Funding

This work was partially funded by the Clinician Scientist Program of the University Arkansas for Medical Sciences and by P30 GM110702. No funding source had any role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.

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  1. Department of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony, Brook University, HSC T10-020, Stony Brook, NY, 11794, USA

    Diane J. Kim, Asha Job, Chuan Huang, Jessica M. Carbajal & Ricardo Cáceda

  2. Psychiatric Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Srinivasa Gokarakonda & Lackshminarayana Chekuri

  3. Department of Radiology, Renaissance School of Medicine at Stony, Brook University, Stony Brook, NY, USA

    Chuan Huang

  4. Psychiatry Service, Northport Veterans Affairs Medical Center, Northport, NY, USA

    Ricardo Cáceda

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RC receives research funding from Neuronetics and Janssen Pharmaceuticals and belongs to Roche’s speaker’s bureau. All the other authors declare no conflict of interests.

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Kim, D.J., Job, A., Gokarakonda, S. et al. Synergistic effect of chronic pain and nonsuicidal self-harm on pain sensitivity. Eur Arch Psychiatry Clin Neurosci 272, 371–380 (2022). https://doi.org/10.1007/s00406-021-01283-7

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