Abstract
The aim of this review is to investigate whether changes in olfactory bulb volume relate to changes in specific olfactory functions. We studied currently available peer-reviewed articles on the volume of the human olfactory bulb that also included a psychophysical measure of olfactory function. In the present review, we observed a very clear and consistent correlation between general olfactory function and olfactory bulb (OB) volume. We were not able to find a clear relationship between a specific smell component and OB volume, even when analyzing pathologic conditions separately. In some cases, changes were observed for different subtests, but these changes did not significantly correlate with OB volume or had only a borderline correlation. In other cases, we found contradictory data. Several factors may contribute to the difficulties in finding correlations with the different components of smell: (1) the OB volume may be influenced by information from olfactory receptor neurons (bottom-up effect), information from central nervous system (top-down effect) and by direct damage; (2) most pathologic conditions affect more than one area of the olfactory pathway; (3) small sample sizes of hyposmic subjects were used. We believe that it is necessary to do further studies with larger numbers of subjects to answer the currently investigated question.
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Brämerson A, Johansson L, Ek L, Nordin S, Bende M (2004) Prevalence of olfactory dysfunction: the Skovde population-based study. Laryngoscope 114:733–737
Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114:1764–1769
Soler GM, Nunez M (2012) The sense of smell in Buenos Aires population: a statistical study. Revista FASO N° 3
Temmel A, Quint C, Schikinger-Fisher B, Klimek L, Stoller E, Hummer T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128:635–641
Damm M, Temmel A, Welge-Lüssen A, Eckel HE, Kreft MP, Klussmann JP, Gudziol H, Hüttenbrink KB, Hummel T (2004) Epidemiologie und therapie von riechstörungen in Deutschland, Österreich und der schweiz. HNO 52:112–120
Buschhüter D, Smitka M, Puschmann S, Gerber JC, Witt M, Abolmaali ND, Hummel T (2008) Correlation between OB volume and olfactory function. Neuroimage 42:498–502
Hummel T, Smitka M, Puschmann S, Gerber JC, Schaal B, Buschhüter D (2011) Correlation between olfactory bulb volume and olfactory function in children and adolescents. Exp Brain Res 214:285–291. doi:10.1007/s00221-011-2832-7
Rombaux PH, Duprez T, Hummel T (2009) Olfactory bulb volume in clinical assessment of olfactory function. Rhinology 47:3–9
Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52
Cain W, Gent JF, Goodspeed RB, Leonard G (1988) Evaluation of olfactory dysfunction in the connecticut chemosensory clinical research center. Laryngoscope 98:83–88
Cain W, Rabin M (1989) Comparability of two tests of olfactory functioning. Chem Senses 14:479–485
Doty RL, Shaman P, Kimmelman CP, Dann MS (1984) University of Pennsylvania smell identification test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 94:176–178
Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T (2010) Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol 32:1062–1067
Lotsch J, Reichmann H, Hummel T (2008) Different odor tests contribute differently to the evaluation of olfactory loss. Chem 33:17–21
Gudziol V, Buschhüter D, Abolmaali N, Gerber J, Rombaux P, Hummel T (2009) Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain 132:3096–3101
Hummel T, Henkel S, Negoias S, Galvan JR, Bogdanov V, Hopp P, Hallmeyer-Elgner S, Gerber J, Reuner U, Haehner A (2013) OB volume in temporal lobe epilepsy. J Neurol 260:1004–1008
Mueller A, Abolmaali ND, Hakimi AR, Gloeckler T, Herting B, Reichmann H, Hummel T (2005) Olfactory bulb volumes in patients with idiopathic Parkinson’s disease a pilot study. J Neural Transm 112:1363–1370
Malnic B, Hirono J, Takaaki S, Buck LB (1999) Combinatorial receptor codes for odors. Cell 96:713–723
Yousem DM, Gekle RJ, Bilker WB, Doty RL (1998) Olfactory bulb and tract and temporal lobe volume. Normative data across decades. Ann NY Acad Sci 855:546–555
Yousem DM, Gekle RJ, Bilker WB, McKeown DA, Doty RL (1996) Posttraumatic olfactory dysfunction: MR and clinical evaluation. Am J Neuroradiol 117:1171–1179
Yousem DM, Gekle RJ, Bilker WB, Kroger H, Doty RL (1999) Posttraumatic smell loss: relationship of psychophysical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol 6:264–272
Rombaux PH, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T (2006) Retronasal and orthonasal olfactory function in relation to olfactory bulb volume in patients with posttraumatic loss of smell. Laryngoscope 116:901–905
Mueller A, Rodewald A, Reden J, Gerber J, von Kummer R, Hummel T (2005) Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. Chem Senses 16:475–478
Rombaux PH, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T (2006) Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 116:436–439
Haehner A, Rodewald A, Gerber JC, Hummel T (2008) Correlation of olfactory function with changes in volume of the human olfactory bulb. Arch Otolaryngol Head Neck Surg 134:621–624
Rombaux PH, Huart C, Deggouj N, Duprez T, Hummel T (2012) Prognostic value of olfactory bulb volume for recovery in postinfectious and posttraumatic olfactory loss. Otolaryngol Head Neck Surg 147:1136–1141
Goektas O, Fleiner F, Sedlmaier B, Bauknecht C (2009) Correlation of olfactory dysfunction of different etiologies in MRI and comparison with subjective and objective olfactometry. Eur J Radiol 71:469–473
Hawkes C (2003) Olfaction in neurodegenerative disorders. Mov Disord 18:364–372
Brodoehl S, Klingner C, Volk GF, Bitter T, Witte OW, Redecker C (2012) Decreased olfactory bulb volume in idiopathic Parkinson’s disease detected by 3.0-tesla magnetic resonance imaging. Mov Disord 27:1019–1025
Chen S, Tan H-Y, Wu Z-H, Sun C-P, He J-X, Li X-C, Shao M (2013) The imaging study of olfactory bulb volume and grey matter volume of olfactory related brain areas in patients with Parkinson’s disease and multiple system atrophy. Radiol. doi:10.1016/j.ejrad.2013.11.024
Thomann PA, Dos Santos V, Toro P, Schonknecht P, Essig M, Schroder J (2009) Reduced olfactory bulb and olfactory tract volume in early Alzheimer’s disease—A MRI study. Neurobiol Aging 30:838–841
Thomann PA, Dos Santos V, Seidl U, Toro P, Essig M, Schroder J (2009) MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 17:213–221
Turetsky BI, Moberg PJ, Yousem DM, Doty RL, Arnold SE, Gur RE (2000) Reduced olfactory bulb volume in patients with Schizophrenia. Am J Psychiatry 157:828–830
Turetsky BI, Moberg PJ, Arnold SE, Doty RL, Gur RE (2003) Low olfactory bulb volume in first-degree relatives of patients with Schizophrenia. Am J Psychiatry 160:703–708
Podlesek D, Leimert M, Schuster B, Gerber J, Schackert G, Kirsh M, Hummel T (2012) Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus. Neuroradiology 54:1229–1233
Negoias S, Croy I, Gerber J, Puschmann S, Petrowski K, Joraschky P, Hummel T (2010) Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 169:415–421
Croy I, Negoias S, Symmank A, Schellong J, Joraschky P, Hummel T (2013) Reduced olfactory bulb volume in adults with history of childhood maltreatment. Chem Senses 38:679–684
Schriever VA, Reither N, Gerber J, Ianilli E, Hummel T (2013) Olfactory bulb volume in smokers. Exp Brain Research 225:153–157
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Mazal, P.P., Haehner, A. & Hummel, T. Relation of the volume of the olfactory bulb to psychophysical measures of olfactory function. Eur Arch Otorhinolaryngol 273, 1–7 (2016). https://doi.org/10.1007/s00405-014-3325-7
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DOI: https://doi.org/10.1007/s00405-014-3325-7