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Association between obstructive sleep apnea and health-related quality of life in individuals affected with Treacher Collins syndrome

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Abstract

Although the relationship between Quality of Life (QoL) and obstructive sleep apnea (OSA) has been reported in several studies, little is known about this relationship among individuals affected with Treacher Collins syndrome (TCS). The aim of this study was to examine the associations between obstructive sleep and QoL in TCS patients. Thirty-six individuals with TCS (8–75 years) were invited to participate in expanded medical examinations, including a sleep study, polysomnography, as well as to respond to questionnaires about health related Health-related quality of life (HRQoL). Twenty-three (64 %) responded to the invitation, but four were later excluded due to additional diagnoses or unconfirmed TCS, and four were below 12 years and excluded due to different scoring rules for sleep and respiratory disturbances in young children and adults. The remaining group comprised 15 adults and adolescents with TCS, 5 male (33 %) and 10 female (66 %). The participants were between 12 and 75 years of age (mean 38.6, SD 18.5). Obstructive sleep was found in 87 % of the patients and several sleep apnea parameters, among these wake time after sleep, subjective snoring and mean saturation, were associated with poorer HRQoL. OSA appears to account for reduced HRQoL in adolescents and adults with TCS.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Social Science, Oslo and Akershus University College of Applied Sciences, St. Olavs Plass, Postbox 4, 0130, Oslo, Norway

    Amy Østertun Geirdal

  2. Department of Medical Genetics, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Amy Østertun Geirdal & Ketil Heimdal

  3. Department of Otorhinolaryngology, Lovisenberg Diakonale Hospital, Oslo, Norway

    Britt Øverland & Harriet Akre

  4. TAKO Center, National Resource Centre for Oral Health in Rare Medical Conditions, Lovisenberg Diakonale Hospital, Oslo, Norway

    Kari Storhaug & Pamela Åsten

  5. University of Oslo, Oslo, Norway

    Harriet Akre

  6. Division of Surgery and Clinical Neuroscience, Department of Otorhinolaryngology, Oslo University Hospital, Oslo, Norway

    Harriet Akre

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  1. Amy Østertun Geirdal
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Correspondence to Amy Østertun Geirdal.

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Geirdal, A.Ø., Øverland, B., Heimdal, K. et al. Association between obstructive sleep apnea and health-related quality of life in individuals affected with Treacher Collins syndrome. Eur Arch Otorhinolaryngol 270, 2879–2884 (2013). https://doi.org/10.1007/s00405-013-2409-0

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  • DOI: https://doi.org/10.1007/s00405-013-2409-0

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