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The patient benefit index: a novel approach in patient-defined outcomes measurement for skin diseases

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Abstract

Evaluation of therapeutic benefits from the patient’s perspective is important in medical decision-making and reimbursement. This study aimed at developing and validating an instrument on patient-defined needs and benefits in dermatology. The questionnaire was developed according to international guidelines. The benefit assessment consists of two steps: before treatment, every patient defines his treatment needs according to a standardized list. After treatment, the patient rates the degree of benefits achieved. A “patient benefit index” (PBI) is calculated by averaging the preference-weighed results of all items. The PBI questionnaire was validated in a sample of 500 patients with ten skin diseases and in a treatment study on 906 patients with acne. The patients defined a broad spectrum of needs and treatment benefits, indicating disease-specific patterns. The PBI showed good feasibility, reliability (Cronbach’s alpha >0.91) and construct validity, high responsiveness, and discrimination between subgroups. The PBI permits valid evaluation of patient-relevant benefits in dermatological treatment.

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Conflict of interest statement

The authors declare that they have no conflict of interest. The clinical trial was supported by a grant from Stiefel GmbH, Offenbach/Germany

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Authors and Affiliations

  1. Department of Dermatology, German Center for Health Services Research in Dermatology (CVderm), University Clinics of Hamburg, Martinistr. 52, 20246, Hamburg, Germany

    Matthias Augustin, Marc A. Radtke, Christine Blome, Julia Behechtnejad, Ines Schäfer & Stephan Jeff Rustenbach

  2. SCIderm GmbH Hamburg, Institute for Clinical Studies, Stephansplatz 5, 20354, Hamburg, Germany

    Ina Zschocke

  3. Dermatology Practice, Tibarg 7-9, Hamburg, Germany

    Michael Reusch & Volker Mielke

Authors
  1. Matthias Augustin
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  2. Marc A. Radtke
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  3. Ina Zschocke
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  4. Christine Blome
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  5. Julia Behechtnejad
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  6. Ines Schäfer
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  7. Michael Reusch
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  8. Volker Mielke
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  9. Stephan Jeff Rustenbach
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Correspondence to Matthias Augustin.

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Augustin, M., Radtke, M.A., Zschocke, I. et al. The patient benefit index: a novel approach in patient-defined outcomes measurement for skin diseases. Arch Dermatol Res 301, 561–571 (2009). https://doi.org/10.1007/s00403-009-0928-8

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  • DOI: https://doi.org/10.1007/s00403-009-0928-8

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