Abstract
Purpose
The metabolic syndrome (MetS) is highly prevalent in Western older populations. MetS is an intriguing entity, because it includes potentially reversible risk factors. Some studies have suggested an inverse correlation between MetS and health-related quality of life (HRQoL), but data regarding older subjects are scanty and conflicting. The aim of this study was to assess the association between HRQoL and MetS in older, unselected community-dwelling subjects.
Methods
We analyzed data of 356 subjects aged 75+ living in Tuscania (Italy). HRQoL was assessed using the Health Utilities Index, Mark 3. Diagnosis of MetS was defined according to the National Cholesterol Education Program’s ATP-III criteria.
Results
MetS was reported by 137 (38%) participants. According to linear regression analysis, MetS was associated with significantly better HRQoL in men (B = 0.19 95% CI = 0.06–0.32; p = 0.006), but not in women. Also, when the regression model was analyzed in men, MetS was associated with better HRQoL (B = 0.17, 95% CI = 0.01–0.32; p = 0.035) only among participants aged 80+. No significant associations were found in men between HRQoL and any of the single components of MetS.
Conclusions
MetS is not associated with worse HRQoL among community-dwelling elderly; it is associated with significantly better HRQoL among the oldest men.
Similar content being viewed by others
References
Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C, American Heart Association; National Heart, Lung, and Blood Institute (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109(3):433–438
Cameron AJ, Shaw JE, Zimmet PZ (2004) The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 33(2):351–375
Gutierrez DA, Puglisi MJ, Hasty AH (2009) Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 9:26–32
Qiao Q, Gao W, Zhang L, Nyamdorj R, Tuomilehto J (2007) Metabolic syndrome and cardiovascular disease. Ann Clin Biochem 44(Pt3):232–263
Thomas GN, Schooling CM, McGhee SM, Ho SY, Cheung BM, Wat NM, Janus ED, Lam KS, Lam TH, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee (2007) Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol 66(5):666–671
Smith KJ, Hsu HE, Roberts MS, Kramer MK, Orchard TJ, Piatt GA, Seidel MC, Zgibor JC, Bryce CL (2010) Cost-effectiveness analysis of efforts to reduce risk of type 2 diabetes and cardiovascular disease in southwestern Pennsylvania, 2005–2007. Prev Chronic Dis 7(5):A109
Tziallas D, Kastanioti C, Kostapanos MS, Skapinakis P, Elisaf MS, Mavreas V (2011) The impact of the metabolic syndrome on health-related quality of life: a cross-sectional study in Greece. Eur J Cardiovasc Nurs, Mar 11
Park SS, Yoon YS, Oh SW (2005) Health-related quality of life in metabolic syndrome: the Korea National Health and Nutrition Examination Survey 2005. Diabetes Res Clin Pract 91(3):381–388
Amiri P, Hosseinpanah F, Rambod M, Montazeri A, Azizi F (2010) Metabolic syndrome predicts poor health-related quality of life in women but not in men: Tehran Lipid and Glucose Study. J Womens Health (Larchmt) 19(6):1201–1207
Sohn YJ, Sohn HS, Kwon JW (2011) Gender differences among middle-aged Koreans for health-related quality of life related to metabolic syndrome. Qual Life Res 20(4):583–592
Ferraroni M, Decarli A, Franceschi S, La Vecchia C, Enard L, Negri E, Parpinel M, Salvini S (1996) Validity and reproducibility of alcohol consumption in Italy. Int J Epidemiol 25(4):775–782
Zuccalà G, Onder G, Pedone C, Cesari M, Landi F, Bernabei R, Cocchi A, Gruppo Italiano di Farmacoepidemiologia nell’Anziano Investigators (2001) Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicenter survey. Alcohol Clin Exp Res 25(12):1743–1748
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA 185:414–419
Lawton MP, Brody EM (1969) Assessment of older: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186
Nardi B, De Rosa M, Paciaroni G, Marchesi GF, Bonaiuto S, Luciani P, Turtù F, Giannandrea E (1991) Clinical investigation on depression on a randomized and stratified sample in an elderly population. Minerva Psichiatr 32(3):135–144
Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO (1982–1983) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17(1):37–49
Hodkinson HM (1972) Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing 1(4):233–238
Rocca WA, Bonaiuto S, Lippi A, Luciani P, Pistarelli T, Grandinetti A, Cavarzeran F, Amaducci L (1992) Validation of the Hodkinson abbreviated mental test as a screening instrument for dementia in an Italian population. Neuroepidemiology 11(4–6):288–295
PHS–HCFA (1980) International classification of diseases, 9th rev. 1980 Public Health Service—Health Care Financing Administration, Washington, DC
Deyo RA, Cherkin DC, Ciol MA (1992) Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 45(6):613–619
Feeny D, Furlong W, Torrance GW, Goldsmith CH, Zhu Z, DePauw S, Denton M, Boyle M (2002) Multiattribute and single-attribute utility functions for the health utilities index mark 3 system. Med Care 40(2):113–128
Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468):1415–1428
Ford ES, Li C (2008) Metabolic syndrome and health-related quality of life among U.S. adults. Ann Epidemiol 18(3):165–171
Rich MW, Nease RF (1999) Cost-effectiveness analysis in clinical practice: the case of heart failure. Arch Intern Med 159(15):1690–1700
Katano S, Nakamura Y, Nakamura A, Suzukamo Y, Murakami Y, Tanaka T, Okayama A, Miura K, Okamura T, Fukuhara S, Ueshima H (2001) Relationship between health-related quality of life and clustering of metabolic syndrome diagnostic components. Qual Life Res [Epub ahead of print]
Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C (2007) Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome. Gerontology 53(6):329–339
Lai MM, Li CI, Kardia SL, Liu CS, Lin WY, Lee YD, Chang PC, Lin CC, Li TC (2010) Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population. BMC Public Health 10:429
Laudisio A, Marzetti E, Pagano F, Pozzi G, Bernabei R, Zuccalà G (2009) Depressive symptoms and metabolic syndrome: selective association in older women. J Geriatr Psychiatry Neurol 22(4):215–222
Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC (2004) Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol 43(8):1439–1444
Acknowledgments
This research was partially supported as a “targeted project” (SS9.4.2) by the Italian Ministry of Health. The authors declare that there are no conflicts of interest in this study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Laudisio, A., Marzetti, E., Antonica, L. et al. Metabolic syndrome and quality of life in the elderly: age and gender differences. Eur J Nutr 52, 307–316 (2013). https://doi.org/10.1007/s00394-012-0337-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00394-012-0337-1