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Elevated carbohydrate antigen 125 levels in hypertrophic cardiomyopathy patients with heart failure

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Abstract

Carbohydrate antigen 125 (CA 125), known as a tumor marker for ovarian cancer, has been reported to increase and relate to severity in heart failure patients with systolic dysfunction. Hypertrophic cardiomyopathy (HCM) has a wide clinical spectrum that often includes heart failure symptoms. The aim of this study was to evaluate the role of CA 125 in HCM patients, its relation to severity of symptoms, and degree of diastolic dysfunction. CA 125 blood levels were determined in 32 HCM patients (21 male; age 51.3 ± 18.4 years) and in 30 healthy volunteers (19 male; age 49.6 ± 16.1 years). Echocardiographic examinations were performed in all patients. The results were grouped according to clinical status (New York Heart Association class) of the patients. The mean serum level of CA 125 was 14.6 ± 23.8 U/ml in the study group and 7.6 ± 4.8 U/ml in the control group. There was no significant difference between the groups (P = 0.12). CA 125 levels increased as the New York Heart Association functional class increased (class I/II: 6.2 ± 2.4 U/ml; class III: 30.6 ± 36.4 U/ml; P < 0.001). The mean CA 125 level in functional class III patients (30.6 ± 36.4 U/ml) was significantly higher than that of the control group (7.6 ± 4.8 U/ml) (P < 0.001) and the functional class I/II group (6.2 ± 2.4 U/ml) (P < 0.001). There was a significant difference over all three diastolic dysfunction groups with respect to CA 125 levels (4.9 ± 1.3 U/ml in impaired relaxation group, 11.8 ± 6.9 U/ml in pseudonormal group, and 52.6 ± 45.6 U/ml in restrictive filling group; P < 0.0001). Serum CA 125 is related to the clinical severity of HCM. Whether CA 125 has a specific biological role in HCM requires further investigation.

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References

  1. SE Bates (1991) ArticleTitleClinical applications of serum tumor markers Ann Intern Med 1165 623–638

    Google Scholar 

  2. HA Fritsche (1993) ArticleTitleSerum tumor markers for patient monitoring: a case oriented approach illustrated with carcinoembriyonic antigen Clin Chem 39 2431–2434 Occurrence Handle8222254 Occurrence Handle1:STN:280:DyaK2c%2FjslGntQ%3D%3D

    PubMed  CAS  Google Scholar 

  3. P Kenemans CA Yedema GG Bon (1993) ArticleTitleCA 125 in gynecological pathology: a review Eur J Obstet Gynecol Reprod Biol 49 115–124 Occurrence Handle8365505 Occurrence Handle10.1016/0028-2243(93)90135-Y Occurrence Handle1:STN:280:DyaK3sznsVSrtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. ME Vander Burg FB Lammes JJ Verwei (1992) ArticleTitleCA 125 in ovarian cancer Neth J Med 40 36–51 Occurrence Handle1:STN:280:DyaK383lt12gtQ%3D%3D

    CAS  Google Scholar 

  5. EH Hopman TJ Helmerhorst JM Bunfrer WW Ten Bukkel Huinink (1993) ArticleTitleHighly elevated serum CA 125 levels in patient with cardiac failure Eur J Obstet Gynecol Reprod Biol 48 71–73 Occurrence Handle8449265 Occurrence Handle10.1016/0028-2243(93)90056-I Occurrence Handle1:STN:280:DyaK3s7ptlygtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. H Nägele M Bahlu R Klapdor D Schaeperkoeter W Rödiger (1999) ArticleTitleCA 125 and its relation to cardiac function Am Heart J 137 1044–1049 Occurrence Handle10347329 Occurrence Handle10.1016/S0002-8703(99)70360-1

    Article  PubMed  Google Scholar 

  7. A D A'loia P Faggiano G Aurigemma L Bontempi G Ruggeri M Metra S Nodari L Dei Cas (2003) ArticleTitleSerum levels of carbohydrate antigen 125 in patients with chronic heart failure. Relation to clinical severity, hemodynamic and Doppler echocardiographic abnormalities and short-term prognosis J Am Coll Cardiol 41 1805–1811 Occurrence Handle10.1016/S0735-1097(03)00311-5 Occurrence Handle1:CAS:528:DC%2BD3sXks1ymt7g%3D

    Article  CAS  Google Scholar 

  8. P Faggiano A D A'loia L Brentana T Bignotti C Fiorina E Vizzardi L Dei Cas (2005) ArticleTitleSerum levels of different tumour markers in patients with chronic heart failure Eur J Heart Fail 7 IssueID1 57–61 Occurrence Handle15642532 Occurrence Handle10.1016/j.ejheart.2004.04.009 Occurrence Handle1:CAS:528:DC%2BD2MXitVensg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  9. NT Kouris ID Zacharos DD Kontogianni GS Goranitou MD Sifaki HE Grassos EM Kalkandi DK Babalis (2005) ArticleTitleThe significance of CA 125 levels in patients with congestive heart failure. Correlation with clinical and echocardiographic parameters Eur J Heart Fail 7 IssueID2 199–203 Occurrence Handle15701467 Occurrence Handle10.1016/j.ejheart.2004.07.015 Occurrence Handle1:CAS:528:DC%2BD2MXhtV2ksb0%3D

    Article  PubMed  CAS  Google Scholar 

  10. E Varol M Ozaydin A Dogan F Kosar (2005) ArticleTitleTumour marker levels in patients with chronic heart failure Eur J Heart Fail 7 IssueID5 840–843 Occurrence Handle15916923 Occurrence Handle10.1016/j.ejheart.2004.12.008 Occurrence Handle1:CAS:528:DC%2BD2MXns1Wltro%3D

    Article  PubMed  CAS  Google Scholar 

  11. HM Turk H Pekdemir S Buyukberber A Sevinc C Camci R Kocabas M Tarakcioglu NM Buyukberber (2003) ArticleTitleSerum CA 125 levels in patients with chronic heart failure and accompanying pleural fluid Tumor Biol 24 172–175 Occurrence Handle10.1159/000074425 Occurrence Handle1:CAS:528:DC%2BD3sXpsVKqsbo%3D

    Article  CAS  Google Scholar 

  12. C Duman E Ercan I Tengiz H Bozdemir HK Ercan I Nalbantgil (2003) ArticleTitleElevated serum CA 125 levels in mitral stenotic patients with heart failure Cardiology 100 7–10 Occurrence Handle12975539 Occurrence Handle10.1159/000072385 Occurrence Handle1:CAS:528:DC%2BD3sXntlSgsr8%3D

    Article  PubMed  CAS  Google Scholar 

  13. SS Lele HL Thomson H Seo I Belenkie WJ McKenna MP Frenneaux (1995) ArticleTitleExercise capacity in hypertrophic cardiomyopathy: role of stroke volume limitation, heart rate, and diastolic filling characteristics Circulation 92 2886–2894 Occurrence Handle7586256 Occurrence Handle1:STN:280:DyaK28%2FntFeitw%3D%3D

    PubMed  CAS  Google Scholar 

  14. MP Frenneaux A Porter ALP Caforio H Odawara PJ Counihan WJ McKenna (1989) ArticleTitleDeterminants of exercise capacity in hypertrophic cardiomyopathy J Am Coll Cardiol 13 1521–1526 Occurrence Handle2723268 Occurrence Handle1:STN:280:DyaL1M3ls1ensQ%3D%3D

    PubMed  CAS  Google Scholar 

  15. P Nihoyannopoulos G Karatasakis M Frenneaux WJ McKenna CM Oakley (1992) ArticleTitleDiastolic function in hypertrophic cardiomyopathy: relation to exercise capacity J Am Coll Cardiol 19 536–540 Occurrence Handle1538006 Occurrence Handle1:STN:280:DyaK387ms1WktQ%3D%3D Occurrence Handle10.1016/S0735-1097(10)80268-2

    Article  PubMed  CAS  Google Scholar 

  16. S Sharma PM Elliot G Whyte S Jones N Mahon B Whipp WJ McKenna (2000) ArticleTitleUtulity of cardiopulmonary exercise in the assessment of clinical determinants of functional capacity in hypertrophic cardiomyopathy Am J Cardiol 86 162–168 Occurrence Handle10913477 Occurrence Handle10.1016/S0002-9149(00)00854-7 Occurrence Handle1:STN:280:DC%2BD3czpvFGrtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  17. C Briguori S Betocchi M Romano F Manganelli M Angela Losi Q Ciampi R Goltilla R Lombardi M Condorelli M Chiarello (1999) ArticleTitleExercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function Am J Cardiol 84 309–315 Occurrence Handle10496441 Occurrence Handle10.1016/S0002-9149(99)00282-9 Occurrence Handle1:STN:280:DyaK1MvisVOlsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. BJ Maron P Spirito KJ Green YE Wesley RO Bonow J Arce (1987) ArticleTitleNoninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in patients with hypertrophic cardiomyopathy J Am Coll Cardiol 10 733–742 Occurrence Handle3655141 Occurrence Handle1:STN:280:DyaL1c%2FgvVKqsA%3D%3D

    PubMed  CAS  Google Scholar 

  19. BJ Maron (2002) ArticleTitleHypertrophic cardiomyopathy: a systemic review JAMA 287 1308–1320 Occurrence Handle11886323 Occurrence Handle10.1001/jama.287.10.1308

    Article  PubMed  Google Scholar 

  20. M Zile D Brutsaert (2002) ArticleTitleNew concepts in diastolic dysfunction and diastolic heart failure: I. Diagnosis, prognosis and measurements of diastolic function Circulation 105 1387 Occurrence Handle11901053 Occurrence Handle10.1161/hc1102.105289

    Article  PubMed  Google Scholar 

  21. PT Lavin RC Knapp G Malkasion CW Whitney JC Berek RC Bast SuffixJr (1987) ArticleTitleCA 125 for the monitoring of ovarian carcinoma during primary therapy Obstet Gynecol 69 223–227 Occurrence Handle2433652 Occurrence Handle1:STN:280:DyaL2s7hs1OrsQ%3D%3D

    PubMed  CAS  Google Scholar 

  22. K Sjovall B Nilsson N Einhorn (2002) ArticleTitleThe significance of serum CA 125 elevation malignant and nonmalignant diseases Gynecol Oncol 85 175–178 Occurrence Handle11925140 Occurrence Handle10.1006/gyno.2002.6603

    Article  PubMed  Google Scholar 

  23. A Sevinç S Buyukberber R Sari HM Turk M Ates (2000) ArticleTitleElevated serum CA 125 levels in patients with nephrotic syndrome induced ascites Anticancer Res 20 1201–1204 Occurrence Handle10810422

    PubMed  Google Scholar 

  24. A Sevinc S Buyukberber R Sari (2000) ArticleTitleElevated serum CA 125 levels: hepatitis or ascites? Gynecol Oncol 76 141–142 Occurrence Handle10620461 Occurrence Handle10.1006/gyno.1999.5670 Occurrence Handle1:STN:280:DC%2BD3c%2FovVyktQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  25. A Sevinc S Buyukberber R Sari Y Kinoglu HM Turk M Ates (2000) ArticleTitleElevated serum CA 125 levels in hemodialysis patients with peritoneal, pleural or pericardial fluids Gynecol Oncol 77 254–257 Occurrence Handle10785474 Occurrence Handle10.1006/gyno.2000.5776 Occurrence Handle1:STN:280:DC%2BD3c3kvFWjtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  26. C Briguori S Betocchi F Managanelli B Gigante MA Losi Q Ciampi R Goltilla A Violante CG Tocchelti M Volpe M Chiarello (2001) ArticleTitleDeterminants and clinical significance of natriuretic peptides in hypertrophic cardiomyopathy Eur Heart J 22 1328–1336 Occurrence Handle11465965 Occurrence Handle10.1053/euhj.2000.2535 Occurrence Handle1:STN:280:DC%2BD3Mvhs12ksw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  27. BJ Maron VN Tholakanahalli AG Zenovich SA Casey D Duprez DM Aeppli JN Cohn (2004) ArticleTitleUsefullness of B-type natriuretic peptide assay in the assessment of symptomatic state in hypertrophic cardiomyopathy Circulation 109 984–989 Occurrence Handle14967727 Occurrence Handle10.1161/01.CIR.0000117098.75727.D8 Occurrence Handle1:CAS:528:DC%2BD2cXhsFeisbk%3D

    Article  PubMed  CAS  Google Scholar 

  28. F Kosar Y Aksoy G Ozguntekin I Ozeral E Varol (2006) ArticleTitleRelationship between cytokines and tumour markers in patients with chronic heart failure Eur J Heart Fail 8 270–274 Occurrence Handle16309955 Occurrence Handle10.1016/j.ejheart.2005.09.002 Occurrence Handle1:CAS:528:DC%2BD28Xks1Wrtbk%3D

    Article  PubMed  CAS  Google Scholar 

  29. AG Zeimet FA Offner C March K Heim H Feichtinger G Daxenbichler O Dapunt (1997) ArticleTitleModulation of CA 125 release by inflammatory cytokines in human peritoneal mesothelial and ovarian cancer cells Anticancer Res 17 3129–3131 Occurrence Handle9329618 Occurrence Handle1:CAS:528:DyaK2sXms12lsLg%3D

    PubMed  CAS  Google Scholar 

  30. I Kubonishi K Bandobaschi N Murata H Daibata E Ido H Sunobe (1997) ArticleTitleHigh serum level of CA 125 and interleukin-6 in a patient with Ki – 1 lymphoma Br J Haematol 98 450–452 Occurrence Handle9266949 Occurrence Handle10.1046/j.1365-2141.1997.2383054.x Occurrence Handle1:STN:280:DyaK2svhtVagtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  31. M Penicka P Gregor J Krupicka M Jira (2001) ArticleTitleTumor necrosis factor-alpha soluble receptors type I are related to symptoms and left ventricular function in hypertrophic cardiomyopathy Can J Cardiol 17 IssueID7 777–784 Occurrence Handle11468644 Occurrence Handle1:STN:280:DC%2BD3MvitVeguw%3D%3D

    PubMed  CAS  Google Scholar 

  32. M Högye Y Mándi M Csanády R Sepp K Buzás (2004) ArticleTitleComparison of circulating levels of inerleukin-6 and tumor necrosis factor–alpha in hypertrophic cardiomyopathy and in idiopathic dilated cardiomyopathy Am J Cardiol 94 249–251 Occurrence Handle15246916 Occurrence Handle10.1016/j.amjcard.2004.03.078 Occurrence Handle1:CAS:528:DC%2BD2cXls1ait7s%3D

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, Isparta State Hospital, Isparta, Turkey

    Ercan Varol

  2. Department of Cardiology, Suleyman Demirel University, Isparta, Turkey

    Mehmet Ozaydin, Ahmet Altinbas, Suleyman M. Aslan, Abdullah Dogan & Ozkan Dede

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  1. Ercan Varol
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  2. Mehmet Ozaydin
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  3. Ahmet Altinbas
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  4. Suleyman M. Aslan
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  5. Abdullah Dogan
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  6. Ozkan Dede
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Correspondence to Ercan Varol.

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Varol, E., Ozaydin, M., Altinbas, A. et al. Elevated carbohydrate antigen 125 levels in hypertrophic cardiomyopathy patients with heart failure. Heart Vessels 22, 30–33 (2007). https://doi.org/10.1007/s00380-006-0938-9

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