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Treatment and outcome in muscle invasive bladder cancer: a population-based survey

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Abstract

Objective

To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region.

Study design and setting

Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN cancer registry. All had a follow-up of at least 5 years. Logistic regression analysis on treatments as well as survival analysis was performed.

Results

The treatments were radical cystectomy in 205/548 (37.5%) patients. TUR plus radiotherapy in 246 (44.9%) and palliation in 97 (17.7%). Multivariate analysis identified TNM stage (P < 0.0001) and age (P < 0.0001) as independent variables for cystectomy. Hospital type and year of diagnosis were not significant different between patients treated by cystectomy versus other type of treatment. TNM stage (P < 0.0001), age (P = 0.0043), and comorbidity (P = 0.0028) were independent variables for disease-specific survival (DSS) after cystectomy.

Conclusion

In the CCCN region, only 1/3 of patients with MIBC were treated with radical cystectomy. TNM stage and age were identified as main variables for the choice for cystectomy. TNM stage, age, and comorbidity were independent variables for disease-specific survival after cystectomy.

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Conflict of interest statement

There is no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, University Medical Center Groningen, Hanzeplein 1, P.O. box 30.001, 9700 RB, Groningen, The Netherlands

    Anna M. Leliveld, Benjamin H. J. Doornweerd & Igle J. de Jong

  2. Comprehensive Cancer Center North East, P.O. box 330, 9700 AH, Groningen, The Netherlands

    Esther Bastiaannet & Michael Schaapveld

Authors
  1. Anna M. Leliveld
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  2. Benjamin H. J. Doornweerd
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  3. Esther Bastiaannet
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  4. Michael Schaapveld
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  5. Igle J. de Jong
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Corresponding author

Correspondence to Anna M. Leliveld.

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Leliveld, A.M., Doornweerd, B.H.J., Bastiaannet, E. et al. Treatment and outcome in muscle invasive bladder cancer: a population-based survey. World J Urol 28, 439–444 (2010). https://doi.org/10.1007/s00345-010-0546-2

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  • DOI: https://doi.org/10.1007/s00345-010-0546-2

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